This LCOR Biologics Sequence Review Report was produced with PatSnap Biology Modality MCP workflows. It connects patent-scale similarity search, sequence retrieval, pairwise alignment and antibody–antigen evidence in a reproducible screen. Explore the PatSnap MCP servers used in this report.
Review date: 17 September 2026. This report supports R&D and IP triage; it is not a legal opinion, freedom-to-operate conclusion or validity analysis. A sequence hit does not establish infringement. “Claimed” is a database annotation that still requires family consolidation, live-claim review and jurisdiction-specific claim construction.
Executive sequence-risk thesis
LCOR is a protein directed to Ligand-dependent corepressor. Public therapeutic sequence data from UniProtKB/Swiss-Prot reviewed human protein record supplied the query material: Full-length protein 433 aa. PatSnap’s all-patent protein search returned a closest review hit at 100.00% query identity across 433/433; the returned record was marked Yes.
The screening conclusion is elevated diligence priority, not “blocked” or “clear.” Similarity is most informative when interpreted by chain, CDR/framework location, construct architecture, target evidence and the language of live claims. Constant-region reuse or a common light chain can produce high percentages without proving asset-level collision, while a small number of substitutions in a CDR or linker junction can be disproportionately important.
Sequence scope and MCP workflow
The review began with traceable UniProtKB/Swiss-Prot reviewed human protein record query sequences. Each full-length protein query was submitted with ls_sequence_search_submit against ALLPATENT and CLAIMS protein records, allowing gaps, using E-value ≤1×10−3 and a 20-record task cap. Results were retrieved with ls_sequence_search_get_results; the closest informative hit was resolved with ls_sequence_fetch and compared using ls_sequence_alignment. ls_patent_sequence_fetch and ls_antibody_antigen_search supplied patent and target context.
Similarity search readout
Query
Search volume
Leading evidence
Full-length protein (433 aa)
20 returned records
100.00% identity; 433/433; claimed: Yes
The largest chain-level result set contained 20 records. These are search records, not unique inventions, enforceable claims or independent families. Publications can repeat the same sequence across jurisdictions, examples, comparators and continuations. Deduplication by earliest priority, applicant, simple family and legal status is required before business conclusions.
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Accelerate Strategic R&D decision making with Synapse, Patsnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Discover Synapse Data Servers
Synapse data is now integrated into the PatSnap LS Model Context Protocol (MCP) service. Customize your LLM agent now using our MCP server!