Ipilimumab ACTRN12626000505303 Clinical Landscape 2026

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This Clinical Landscape Report was built with PatSnap Life Sciences MCP workflows. Clinical Trials MCP supplies protocol and result records, Drug & Asset MCP adds asset context, and Company & Deal Intelligence MCP resolves sponsor background. Use the same structured MCP building blocks in your research workflow.

Data snapshot: 11 September 2026. This strategic research report is not medical, regulatory or investment advice. Trial status and dates can change.

Phase 1

Clinical phase

Not yet recruiting

Recruitment status

50

Planned enrollment

Timing not reported

Primary-completion proxy

Executive view

ACTRN12626000505303 evaluates Ipilimumab in Mesothelioma, Malignant. The disclosed sponsor is Fiona Stanley Hospital, the design is Interventional, and the geographic footprint is Australia. The first listed primary endpoint is not reported, assessed over an unreported time frame.

The key landscape question is whether this protocol can generate a clinically interpretable signal relative to nearby programs. Phase alone is not a measure of evidence quality. Endpoint relevance, comparator choice, masking, enrollment feasibility, patient selection, country coverage and follow-up must be considered together.

PatSnap MCP Servers make this assessment reproducible by keeping protocol facts, result evidence, asset attributes and sponsor identity in separate structured calls.

How the MCP evidence stack was assembled

Clinical Trials MCP clinical_trial_fetch retrieved the design, outcomes, phase, status, enrollment, sponsor, countries and timing for ACTRN12626000505303 and selected peers. clinical_trial_result_fetch supplied detailed result records from the wider Mesothelioma, Malignant landscape. Drug & Asset MCP drug_fetch was queried for Ipilimumab, while Company & Deal Intelligence MCP organization_fetch was queried for Fiona Stanley Hospital.

This separation reduces a common diligence error: treating a registry label, a company description or a result excerpt as if each represented the complete evidence package. Explore the source workflow at the PatSnap MCP marketplace.

Trial landscape table

Trial	Asset / intervention	Phase / status	Sponsor	Geography	Primary endpoint	Readout proxy
ACTRN12626000505303	Ipilimumab	Phase 1 / Not yet recruiting	Fiona Stanley Hospital	Australia		Timing not reported
NCT07705074	[18F]FAPI-74	Phase 1/2 / Not yet recruiting	University of Zurich	Switzerland	Diagnostic Interpretability and Uptake Classification of [18F]FAPI-74 PET Imaging At the time of [18F]FAPI-74 PET/CT or PET/MR image acquisition and in…	2029-09-01
NCT07602946	Navlimetostat	Phase 2 / Not yet recruiting	The University of Southampton	United Kingdom	SELECTmeso Platform : Molecular profiling of participant's tumour block SELECTmeso1: Disease Control Rate (DCR) using R… SELECTmeso Platform: Baseline SELECTmeso1: at 12 weeks of treatment	2027-07-01
NCT07563738	Ipilimumab	Phase 1/2 / Recruiting	Sponsor not reported	United States	Incidence of Dose Limiting Toxicities and Adverse Events Through study completion, on average of 2 years	2029-09-01
NCT07532902	Ipilimumab	Phase 1 / Recruiting	Memorial Sloan Kettering Cancer Center	United States	determine a recommended phase II dose (RP2D) of BMS-986504 in combination with standard-of-care therapy 2 years	2029-04-01

The table aligns endpoints, sponsors, phases, geographies and readout proxies. It is descriptive, not a head-to-head efficacy comparison. Differences in population, baseline risk, intervention schedule and follow-up can dominate apparent cross-trial differences.

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Protocol design and endpoint interpretation

ACTRN12626000505303 is a Phase 1, not yet recruiting study with 50 planned participants. Allocation is Non-randomised trial, masking is Open (masking not used), and the intervention model is not reported.

The primary endpoint is “not reported” over “not reported.” The retrieved endpoint description is: 1. Maximum Tolerated Dose (MTD) of [¹77Lu]Lu-FAP-2286: MTD is defined as the highest radioactivity dose level at which no more than 1 out of 6 patients experiences a DLT in the first cycle. [DLT evaluation: The number and type of DLTs observed at each dose level will be summarised descriptively, and the MTD determined according to the 3+3 design rules. The determination of MTD follows the 3+3 escalation rules described. If the highest planned dose (5.55 GBq) is reached with 1 of 6 DLT, it may be declared the MTD (or more precisely that MTD was not exceeded in the tested range, and that becomes RP2D if efficaciou….

Interpretation should test whether the endpoint captures a clinically meaningful change, whether its time horizon matches the proposed biology, and whether treatment discontinuation or missing data can bias the estimate. The planned enrollment of 50 should be assessed against expected effect size, event frequency, multiplicity, subgroup plans and attrition.

No named control drug was returned in the protocol field set. A placebo comparator can strengthen internal efficacy assessment, while an active comparator may better test clinical differentiation. Single-arm and open-label programs require greater weight on objective outcomes, independent assessment and external benchmarks.

Indexed readouts in the surrounding landscape

5 recent result records were selected as contextual evidence for Mesothelioma, Malignant. These records do not establish direct evidence for ACTRN12626000505303 unless the registration number matches.

First-Line Pumitamig (PD-L1 × VEGF-A bsAb) Plus Chemotherapy in Unresectable Malignant Mesothelioma: Long-Term PFS and OS

Phase 2; n=31; OS(24-month) = 25.0 % ; OS(24-month) = 50.7 % Source: https://cattendee.abstractsonline.com/meeting/21487/Session/133

Phase II Trial of Olaparib in Patients With Mesothelioma

Phase 2; n=34; ORR = 3.0 % Source: https://cattendee.abstractsonline.com/meeting/21487/Session/195

Checkmate 6DW: First-Line Nivolumab+Ipilimumab vs Platinum+Pemetrexed for Pleural Mesothelioma in Chinese Patients

Phase 2; n=102; mPFS = 6.97 month ; mPFS = 6.93 month Source: https://cattendee.abstractsonline.com/meeting/21487/Session/195

Result fields should be reconciled with the source record before quantitative comparison. Population definitions, analysis sets, dose cohorts, estimands, confidence intervals, rescue therapy and follow-up can materially change the meaning of a numerical endpoint. Clinical Trials MCP supports repeatable refreshes as result records change.

Asset and sponsor context

No exact Drug & Asset MCP profile was returned for the protocol wording “Ipilimumab.” The report therefore avoids inferring modality, target or global development stage from the name alone.

Fiona Stanley Hospital is indexed in United States with the website https://www.fsh.health.wa.gov.au. Fiona Stanley Hospital provides mental health, medical, emergency surgery, critical care and rehabilitation services. The record lists an unreported number of development-stage drug assets.

For execution diligence, monitor sponsor ownership, collaborator additions, site expansion, protocol amendments and enrollment revisions. A change in ownership or geography can alter operational confidence as well as the commercial meaning of a future readout.

Development white space

Endpoint white space. Determine whether a more patient-relevant outcome, longer durability window or blinded central assessment would resolve uncertainty left by the current endpoint.
Population white space. Test biomarker-defined, treatment-line or risk-stratified subgroups where effect size and unmet need could be clearer.
Comparator white space. Identify whether the study can support differentiation against the current standard of care rather than only activity against baseline or placebo.
Geographic white space. Assess whether the disclosed footprint supports recruitment, regulatory transferability and commercial generalizability.
Sequencing white space. Clarify whether Ipilimumab is intended for monotherapy, combination, maintenance, rescue or an earlier treatment line.

White space should be framed as an unanswered development question, not merely an unoccupied mechanism label. A credible program closes a measurable clinical uncertainty with a design that can be executed and interpreted.

Strategic implications and next readouts

For sponsors, the endpoint hierarchy, safety window, enrollment pace and protocol amendment history should all support the same target product profile. Advancement criteria should be set before the readout and tied to clinical effect, uncertainty, tolerability and operational feasibility.

For business-development teams, differentiation may come from a sharper population, stronger comparator, more durable benefit, simpler delivery or clearer sequencing role. For investors, the central risk is evidence quality relative to time and capital, not the phase label in isolation.

Track recruitment status, enrollment changes, primary-completion timing, endpoint revisions, new result records, sponsor ownership and collaborator changes. Re-run the PatSnap MCP workflow when a surrogate becomes a clinical outcome, a single-country study expands, the comparator changes or a new result materially shifts the competitive benchmark.

Source trail and bottom line

Anchor trial: ACTRN12626000505303
Protocol source: https://anzctr.org.au/ACTRN12626000505303.aspx
MCP sources: Clinical Trials MCP (clinical_trial_fetch and clinical_trial_result_fetch); Drug & Asset MCP (drug_fetch); Company & Deal Intelligence MCP (organization_fetch).
Data snapshot: 11 September 2026.

Ipilimumab in Mesothelioma, Malignant is best understood through the interaction of protocol design, surrounding readouts, asset context and sponsor execution. The current record makes the primary endpoint and Timing not reported the leading decision points.

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