Apatinib Mesylate in Metastatic Pancreatic Cancer: NCT07802184 Clinical Landscape Report 2026
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This Clinical Landscape Report was built with PatSnap Life Sciences MCP workflows. Clinical Trials MCP supplies protocol and result records, Drug & Asset MCP adds asset context, and Company & Deal Intelligence MCP resolves sponsor background. Use the same structured MCP building blocks in your research workflow.
Data snapshot: 11 September 2026. This strategic research report is not medical, regulatory or investment advice. Trial status and dates can change.
Phase 1/2
Clinical phase
Not yet recruiting
Recruitment status
45
Planned enrollment
2029-01-01
Primary-completion proxy
Executive view
NCT07802184 evaluates Apatinib Mesylate in Metastatic Pancreatic Cancer. The disclosed sponsor is West China Hospital, the design is Interventional, and the geographic footprint is China. The first listed primary endpoint is Recommended Phase II Dose (RP2D), assessed over through phase I study completion, an average of 5 months.
The key landscape question is whether this protocol can generate a clinically interpretable signal relative to nearby programs. Phase alone is not a measure of evidence quality. Endpoint relevance, comparator choice, masking, enrollment feasibility, patient selection, country coverage and follow-up must be considered together.
PatSnap MCP Servers make this assessment reproducible by keeping protocol facts, result evidence, asset attributes and sponsor identity in separate structured calls.
How the MCP evidence stack was assembled
Clinical Trials MCP clinical_trial_fetch retrieved the design, outcomes, phase, status, enrollment, sponsor, countries and timing for NCT07802184 and selected peers. clinical_trial_result_fetch supplied detailed result records from the wider Metastatic Pancreatic Cancer landscape. Drug & Asset MCP drug_fetch was queried for Apatinib Mesylate, while Company & Deal Intelligence MCP organization_fetch was queried for West China Hospital.
This separation reduces a common diligence error: treating a registry label, a company description or a result excerpt as if each represented the complete evidence package. Explore the source workflow at the PatSnap MCP marketplace.
Trial landscape table
| Trial | Asset / intervention | Phase / status | Sponsor | Geography | Primary endpoint | Readout proxy |
|---|---|---|---|---|---|---|
| NCT07802184 | Apatinib Mesylate | Phase 1/2 / Not yet recruiting | West China Hospital | China | Recommended Phase II Dose (RP2D) through phase I study completion, an average of 5 months | 2029-01-01 |
| NCT07814066 | SKB-571 | Phase 2 / Not yet recruiting | Sichuan Kelun Botai Biomedicine Co., Ltd. | Geography not reported | Objective response rate (ORR) Up to approximately 24 months. | 2028-02-28 |
| NCT07808567 | Albumin-Bound Paclitaxel | Phase 2 / Not yet recruiting | Gustave Roussy, Cancer Campus, Grand Paris | France | Major pathological response rate (mPR) on surgical resection specimen After pancreatic surgical resection, after 28 days of treatment | 2029-01-01 |
| NCT07805954 | Zoldonrasib | Phase 3 / Recruiting | Revolution Medicines, Inc. | United States | Progression free survival (PFS) Up to approximately 4 years | 2029-03-01 |
| NCT07806058 | HRS-4642 | Phase 1/2 / Not yet recruiting | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | China | RDE in advanced pancreatic cancer with RAS mutation or amplification From the signing of the informed consent form to the end of the safet… | 2028-12-31 |
The table aligns endpoints, sponsors, phases, geographies and readout proxies. It is descriptive, not a head-to-head efficacy comparison. Differences in population, baseline risk, intervention schedule and follow-up can dominate apparent cross-trial differences.
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Protocol design and endpoint interpretation
NCT07802184 is a Phase 1/2, not yet recruiting study with 45 planned participants. Allocation is N/A, masking is None (Open Label), and the intervention model is Single Group Assignment.
The primary endpoint is “Recommended Phase II Dose (RP2D)” over “through phase I study completion, an average of 5 months.” The retrieved endpoint description is: RP2D will be determined on the basis of evaluation on safety and efficacy data in Phase Ib..
Interpretation should test whether the endpoint captures a clinically meaningful change, whether its time horizon matches the proposed biology, and whether treatment discontinuation or missing data can bias the estimate. The planned enrollment of 45 should be assessed against expected effect size, event frequency, multiplicity, subgroup plans and attrition.
No named control drug was returned in the protocol field set. A placebo comparator can strengthen internal efficacy assessment, while an active comparator may better test clinical differentiation. Single-arm and open-label programs require greater weight on objective outcomes, independent assessment and external benchmarks.
Indexed readouts in the surrounding landscape
5 recent result records were selected as contextual evidence for Metastatic Pancreatic Cancer. These records do not establish direct evidence for NCT07802184 unless the registration number matches.
A Pilot Study of Pembrolizumab and Liver-Directed Therapy or Peptide Receptor Radionuclide Therapy for Patients With Well-Differentiated Neuroendocrine Tumors and Symptomatic and/…
Phase 2; n=32; Proportion of Participants With an Overall Response = 0.35 proportion of participants (90% Confidence Interval, 0.20 - 0.52); Proportion of Participants With an Overall Response = 0 proportion of participants (90% Confidence Interval, 0 - 0.63) Source: https://clinicaltrials.gov/ct2/show/results/NCT03457948
A Phase 2 Multi-center, Open-label, Single Arm Study of Nab-sirolimus in Patients With Well-differentiated Neuroendocrine Tumors (NETs) of the Gastrointestinal Tract, Lung, or Pan…
Phase 2; n=12; Percentage of Participants With Objective Response Rate = 8.3 Percent of participants (95% Confidence Interval, 0.2 - 38.5) Source: https://clinicaltrials.gov/ct2/show/results/NCT05997056
Adjuvant Chemotherapy ± Chemoradiotherapy for Adenocarcinoma of the Pancreatic Head: Results of the Radiotherapy Random Assignment of NRG Oncology/RTOG 0848
Phase 3; n=354; mOS = 2.3 year ( 2.0 - 2.6); mOS = 2.6 year ( 2.1 - 3.1) Source: https://pubmed.ncbi.nlm.nih.gov/42456089/
Result fields should be reconciled with the source record before quantitative comparison. Population definitions, analysis sets, dose cohorts, estimands, confidence intervals, rescue therapy and follow-up can materially change the meaning of a numerical endpoint. Clinical Trials MCP supports repeatable refreshes as result records change.
Asset and sponsor context
Apatinib Mesylate is indexed as Small molecule drug with VEGFR2 biology and a global stage of Approved. The asset profile lists Advenchen Laboratories LLC as an originator or developer.
West China Hospital is indexed in China with the website https://wchscu.cn. West China Hospital, Sichuan University offers medical care, research, and education as a teaching hospital with specialized departments. The record lists 174 development-stage drug assets.
For execution diligence, monitor sponsor ownership, collaborator additions, site expansion, protocol amendments and enrollment revisions. A change in ownership or geography can alter operational confidence as well as the commercial meaning of a future readout.
Development white space
- Endpoint white space. Determine whether a more patient-relevant outcome, longer durability window or blinded central assessment would resolve uncertainty left by the current endpoint.
- Population white space. Test biomarker-defined, treatment-line or risk-stratified subgroups where effect size and unmet need could be clearer.
- Comparator white space. Identify whether the study can support differentiation against the current standard of care rather than only activity against baseline or placebo.
- Geographic white space. Assess whether the disclosed footprint supports recruitment, regulatory transferability and commercial generalizability.
- Sequencing white space. Clarify whether Apatinib Mesylate is intended for monotherapy, combination, maintenance, rescue or an earlier treatment line.
White space should be framed as an unanswered development question, not merely an unoccupied mechanism label. A credible program closes a measurable clinical uncertainty with a design that can be executed and interpreted.
Strategic implications and next readouts
For sponsors, the endpoint hierarchy, safety window, enrollment pace and protocol amendment history should all support the same target product profile. Advancement criteria should be set before the readout and tied to clinical effect, uncertainty, tolerability and operational feasibility.
For business-development teams, differentiation may come from a sharper population, stronger comparator, more durable benefit, simpler delivery or clearer sequencing role. For investors, the central risk is evidence quality relative to time and capital, not the phase label in isolation.
Track recruitment status, enrollment changes, primary-completion timing, endpoint revisions, new result records, sponsor ownership and collaborator changes. Re-run the PatSnap MCP workflow when a surrogate becomes a clinical outcome, a single-country study expands, the comparator changes or a new result materially shifts the competitive benchmark.
Source trail and bottom line
Anchor trial: NCT07802184
Protocol source: https://clinicaltrials.gov/study/NCT07802184
MCP sources: Clinical Trials MCP (clinical_trial_fetch and clinical_trial_result_fetch); Drug & Asset MCP (drug_fetch); Company & Deal Intelligence MCP (organization_fetch).
Data snapshot: 11 September 2026.
Apatinib Mesylate in Metastatic Pancreatic Cancer is best understood through the interaction of protocol design, surrounding readouts, asset context and sponsor execution. The current record makes Recommended Phase II Dose (RP2D) and 2029-01-01 the leading decision points.
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