NCT07492680 Pumitamig Liver Cancer Clinical Landscape Report 2026: Design, Endpoints, Sponsor and Readout Outlook
Turn a newly registered trial into a decision-ready clinical landscape. This report examines NCT07492680 using PatSnap Clinical Trials MCP for protocol design and endpoint evidence, with Drug & Asset MCP and Company & Deal Intelligence MCP used as the companion asset and sponsor enrichment workflow. Explore PatSnap MCP Servers to reproduce the research sequence inside an AI workflow.
MCP evidence snapshot: 26 August 2026. Trial records, recruitment status and projected dates can change after the snapshot and should be rechecked before operational decisions.
Why NCT07492680 is a hot trial to watch
Liver Cancer is being segmented by mechanism, treatment setting, geography and endpoint architecture. NCT07492680 is notable because it evaluates Pumitamig in a Phase 2 design sponsored by Bristol Myers Squibb Co.. The main development question is whether the protocol can translate its rationale into a clinically interpretable and operationally credible readout.
Trial landscape snapshot
| Field | Indexed detail |
|---|---|
| Registration | NCT07492680 |
| Official title | A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5) |
| Phase / status | Phase 2 / Recruiting |
| Intervention | Pumitamig |
| Sponsor | Bristol Myers Squibb Co. |
| Geography | Canada, South Korea, Hong Kong, Belgium, Norway, United States, Japan, Ireland, China, Italy, France, Germany, Spain |
| Enrollment | [object Object] |
| Primary endpoint | Part 1: Number of participants who achieve Objective Response (OR) |
| Endpoint time frame | Up to approximately 2 years |
| Primary completion / readout proxy | [object Object] |
Protocol design and endpoint interpretation
This is an open-label, multicenter Phase 2 study evaluating BMS-986504 in participants with advanced and/or metastatic solid tumors that have MTAP deletion. The study includes a monotherapy component and a combination component in which BMS-986504 is given with other anti-cancer agents. The trial will assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of BMS-986504 alone and in combination regimens.
Allocation is N/A, masking is None (Open Label), and the intervention model is Single Group Assignment. Planned enrollment of [object Object] participants across Canada, South Korea, Hong Kong, Belgium, Norway, United States, Japan, Ireland, China, Italy, France, Germany, Spain shapes statistical precision, execution risk and external validity. Interpretation should account for baseline risk, prior therapy, assessment schedule, missing-data handling and clinical relevance—not only statistical significance.
- Part 1: Number of participants who achieve Objective Response (OR) (Up to approximately 2 years) — OR is defined as confirmed complete response (CR) or partial response (PR) by Response Evaluation Criteria in Solid Tumors (RECIST) v1.1, Response Assessment in Neuro-Oncology (RANO) v2 or Modified RECIST v1.1
- Part 2: Number of participants with adverse events meeting protocol defined dose limiting toxicities (DLTs) criteria (Up to approximately 2 years)
- Part 2: Number of participants with adverse events (AE) (Up to approximately 2 years)
- Part 2: Number of participants with Serious AEs (SAEs) (Up to approximately 2 years)
Readout outlook and evidence gap
The current protocol points to [object Object] as the best available readout proxy. Because this is an active or newly posted study, a trial-specific result citation is not included until a normalized clinical-trial-result record becomes available. That gap is itself operationally important: teams should monitor first result indexing, conference abstracts, protocol amendments and changes to the primary-completion date.
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Asset and sponsor context
Drug & Asset MCP profile: Pumitamig is indexed as No normalized modality returned, with target No normalized target returned, mechanism No normalized mechanism returned, and global highest development status No normalized global status returned.
Company & Deal Intelligence MCP profile: Bristol Myers Squibb Co. is resolved to a normalized organization record in MERCER COUNTY, United States. The organization workflow adds identity, location, portfolio and partnering context where available.
The sponsor profile matters because scientific rationale alone does not determine development value. Manufacturing readiness, portfolio fit, geographic reach, partnering capacity and the ability to fund confirmatory development can determine whether a positive signal becomes a competitive asset.
White space around this program
- Sharper patient selection: prospective biomarker or phenotype definitions that identify who is most likely to benefit.
- Clinically interpretable endpoints: outcomes connecting activity with function, symptoms, survival or treatment burden.
- Comparator relevance: evidence against the most decision-relevant contemporary standard of care.
- Broader external validity: evidence across additional geographies, demographic groups and real-world settings.
- Operational differentiation: a development path that closes the readout gap without sacrificing safety or durability.
What to monitor next
Monitor recruitment, enrollment changes, protocol amendments, endpoint hierarchy, primary-completion timing, first result indexing, asset ownership and sponsor partnerships. A change in endpoint, population or ownership can alter the probability of success before a headline data release.
Bottom line
NCT07492680 provides a focused lens on Liver Cancer development. Its value will be determined by whether Pumitamig can convert the current Phase 2 design into evidence that is clinically meaningful, operationally credible and differentiated from competing programs.
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