NCT07772531 Evifacotrep Depressive Disorder, Major Clinical Landscape Report 2026: Design, Endpoints, Sponsor and Readout Outlook
Turn a newly registered trial into a decision-ready clinical landscape. This report examines NCT07772531 using PatSnap Clinical Trials MCP for protocol design and endpoint evidence, with Drug & Asset MCP and Company & Deal Intelligence MCP used as the companion asset and sponsor enrichment workflow. Explore PatSnap MCP Servers to reproduce the research sequence inside an AI workflow.
MCP evidence snapshot: 1 September 2026. Trial records, recruitment status and projected dates can change after the snapshot and should be rechecked before operational decisions.
Why NCT07772531 is a hot trial to watch
Depressive Disorder, Major is being segmented by mechanism, treatment setting, geography and endpoint architecture. NCT07772531 is notable because it evaluates Evifacotrep in a Phase 2 design sponsored by Bristol Myers Squibb Co.. The main development question is whether the protocol can translate its rationale into a clinically interpretable and operationally credible readout.
Trial landscape snapshot
| Field | Indexed detail |
|---|---|
| Registration | NCT07772531 |
| Official title | A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder |
| Phase / status | Phase 2 / Not yet recruiting |
| Intervention | Evifacotrep |
| Sponsor | Bristol Myers Squibb Co. |
| Geography | Czechia, United States |
| Enrollment | 200 |
| Primary endpoint | Mean change from baseline in Hamilton Depression Rating Scale -17 Item (HDRS-17) total score |
| Endpoint time frame | Up to Day 57 |
| Primary completion / readout proxy | Not reported |
Protocol design and endpoint interpretation
A Study to Evaluate BMS-986511 in Adults with Major Depressive Disorder
Allocation is Randomized, masking is Quadruple, and the intervention model is Sequential Assignment. Planned enrollment of 200 participants across Czechia, United States shapes statistical precision, execution risk and external validity. Interpretation should account for baseline risk, prior therapy, assessment schedule, missing-data handling and clinical relevance—not only statistical significance.
- Mean change from baseline in Hamilton Depression Rating Scale -17 Item (HDRS-17) total score (Up to Day 57)
Readout outlook and evidence gap
The current protocol points to Not reported as the best available readout proxy. Because this is an active or newly posted study, a trial-specific result citation is not included until a normalized clinical-trial-result record becomes available. That gap is itself operationally important: teams should monitor first result indexing, conference abstracts, protocol amendments and changes to the primary-completion date.
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Asset and sponsor context
Drug & Asset MCP profile: Evifacotrep is indexed as No normalized modality returned, with target No normalized target returned, mechanism No normalized mechanism returned, and global highest development status No normalized global status returned.
Company & Deal Intelligence MCP profile: Bristol Myers Squibb Co. is resolved to a normalized organization record in MERCER COUNTY, United States. The organization workflow adds identity, location, portfolio and partnering context where available.
The sponsor profile matters because scientific rationale alone does not determine development value. Manufacturing readiness, portfolio fit, geographic reach, partnering capacity and the ability to fund confirmatory development can determine whether a positive signal becomes a competitive asset.
White space around this program
- Sharper patient selection: prospective biomarker or phenotype definitions that identify who is most likely to benefit.
- Clinically interpretable endpoints: outcomes connecting activity with function, symptoms, survival or treatment burden.
- Comparator relevance: evidence against the most decision-relevant contemporary standard of care.
- Broader external validity: evidence across additional geographies, demographic groups and real-world settings.
- Operational differentiation: a development path that closes the readout gap without sacrificing safety or durability.
What to monitor next
Monitor recruitment, enrollment changes, protocol amendments, endpoint hierarchy, primary-completion timing, first result indexing, asset ownership and sponsor partnerships. A change in endpoint, population or ownership can alter the probability of success before a headline data release.
Bottom line
NCT07772531 provides a focused lens on Depressive Disorder, Major development. Its value will be determined by whether Evifacotrep can convert the current Phase 2 design into evidence that is clinically meaningful, operationally credible and differentiated from competing programs.
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