Osteosarcoma

Two PROTAC synergy using two E3 ligases for achieving levels of degradation of KRAS G12D not achieved with single PROTACs, will be presented by the lab of Luca Busino, PhD, from the University of Pennsylvania, on April 27thSEED’s first IND candidate project targeting RBM39: Ewing sarcoma will be presented as an important target on April 30th KING OF PRUSSIA, Pa. , April 24, 2025 (GLOBE NEWSWIRE) -- SEED Therapeutics Inc. (“SEED”), a biotechnology company pioneering the discovery of molecular glues for targeted protein degradation (TPD) using its proprietary RITE3SM platform, today announced that breakthrough research from two of SEED’s pipeline projects will be presented as posters at the 2025 Annual Meeting of the American Association for Cancer Research (“AACR”) beginning Sunday, April 27th through April 30th, 2025 in Chicago, Illinois. Poster Presentation details are as follows: Title: “Combinatorial Use of VHL and KEAP1-based PROTACs Reveals Unexpected Synergy and Hook Effect Relief” Presenter / Author: Sehbanul Islam, Haihong Jin, Dong Liu, Dan Lu, Yunkai Zhang, Renxu Chang, Joel Austin, Thomas Beer, Hsin-Yao Tang, Lan Huang, James Tonra, Luca BusinoPresentation Time: 4/27/2025 2PM to 5PM CTLocation: Poster Section 18 at Exhibit Hall at McCormick Place Convention CenterSession Title: Degrader and Glues 1Presentation Number: 397Abstract Control Number: 2582 Title: “Targeting Ewing Sarcoma with a Novel RBM39 Degrader: DNA Damage Repair Pathway Effects” Presenter / Author: Fei Liu, Yunkai Zhang, Baiyun Wang, James Finn, James Tonra, Lan Huang, Dong Liu, Haihong Jin, Xing Liu, Dan LuPresentation Time: 4/30/2025 9AM to 12PM CTLocation: Poster Section 28 at Exhibit Hall at McCormick Place Convention CenterSession Title: Advances in Translational Pediatric Cancer ResearchPresentation Number: 7035Abstract Control Number: 1556 On Sunday April 27th, Sebhanul Islam, PhD, a postdoctoral fellow in the lab of Luca Busino, PhD, an associate professor of Cancer Biology in the Perelman School of Medicine at the University of Pennsylvania, will share and discuss a poster titled, “Combinatorial use of VHL and KEAP1-based PROTACs reveals unexpected synergy and hook effect relief,” related to the targeting of mutant KRAS G12D as well as other oncogenes. “Our team’s research experimentally demonstrated anticancer synergy between two PROTACS using different E3 ligases to target the same oncogene and kill cancer cells,” Dr. Busino said. “We are excited to share this data on superior degradation efficacy against KRAS G12D, a long-targeted oncogene, with the scientific community at the AACR Annual Meeting, and grateful to SEED for providing funding support for this research.” James Tonra, PhD, SEED’s President and CSO added, “While SEED’s platform and pipeline is focused on molecular glues, we recognized with Dr. Busino early on, that the PROTAC synergy discovered in our collaboration had great potential to impact clinical trial success and human health. We therefore supported and assisted the expert research performed at Penn to convincingly demonstrate this potential and are very pleased to discuss the results and next steps at AACR.” On Wednesday, April 30th, SEED’s pharmacology group will present their work titled, “Targeting Ewing sarcoma with a novel RBM39 degrader: DNA damage repair pathway effects”, related to SEED’s rational design strategy for upcoming clinical testing of its lead project that is advancing towards an IND filing in the middle of this year. Dr. Huang stated, “SEED is rapidly transitioning into a clinical-stage company, with the planned IND filing for ST-01156, our novel and potentially best-in-class RBM39 degrader. At SEED, we are committed to improving patient outcomes through pioneering science and rational drug development, and SEED’s second poster at the AACR Annual Meeting demonstrates this commitment by sharing data supporting Ewing sarcoma as an important cancer type for inclusion in clinical trials for ST-01156. This indication has been granted Rare Pediatric Disease and Orphan Drug designations by the FDA. Importantly, our scientists continue to add to the list of cancer types for inclusion in our RBM39 degrader clinical trials through MoA-based approaches and work with leading US clinical institutions to increase clinical success probability.” About SEED TherapeuticsSEED Therapeutics is a biotech company pioneering targeted protein degradation (TPD). Its proprietary RITE3SM platform is advancing novel molecular glue degraders across oncology, neurodegeneration, immunology, and virology. SEED collaborates with Eli Lilly and Company and Eisai Co., Ltd. and is advancing its RBM39 degrader into clinical development. Learn more at seedtherapeutics.com. Investor Contact: IR@seedtherapeutics.comMedia Contact: PR@seedtherapeutics.com

Decoy’s development of novel peptide-conjugate therapeutics arising from its proprietary IMP3ACT™ platform to benefit from Dr. Langer’s extensive scientific knowledge and experienceCAMBRIDGE, Mass. and HOUSTON, April 16, 2025 (GLOBE NEWSWIRE) -- Decoy Therapeutics, Inc. (Decoy), a privately held preclinical biopharmaceutical company engineering the next generation of peptide conjugate therapeutics, announces that Massachusetts Institute of Technology (MIT) Professor and Moderna co-founder Robert S. Langer, ScD will join the company’s Scientific Advisory Board (SAB) upon the successful completion of Decoy’s merger with Salarius Pharmaceuticals, Inc. (NASDAQ: SLRX). As announced on January 13, 2025, Decoy and Salarius Pharmaceuticals signed a definitive agreement under which Decoy Therapeutics will merge with a wholly owned subsidiary of Salarius Pharmaceuticals, with the newly formed company to be named Decoy Therapeutics. Dr. Langer is a world-renowned scientist, entrepreneur and biotechnology visionary. His groundbreaking work in drug delivery systems design and in tissue engineering have earned him numerous awards, including the prestigious National Medal of Science and the Charles Stark Draper Prize. Drug development technologies that Dr. Langer pioneered have laid the foundations for transformative medicines including Roche’s cancer drug bevacizumab (Avastin®) and Moderna's Spikevax® mRNA Covid vaccine. "It’s an honor to have Dr. Langer join our SAB,” commented Michael M. Lipp, PhD, Chief Technology Officer of Decoy. “Having worked in Dr. Langer’s lab and at start-up companies that were founded on innovations arising from his lab, I’ve seen first-hand the impact he brings in discovering transformational therapies and advancing their development. We are confident that Dr. Langer’s tremendous experience and know-how will provide invaluable support as we use our proprietary IMP3ACT platform to advance a portfolio of proprietary peptide-conjugate products.” “Decoy is utilizing an innovative, next-generation peptide-conjugate platform to discover and develop much-needed and differentiated antiviral and cancer therapies,” said Dr. Langer. “I am excited to collaborate with the Decoy team and to lend my expertise to expedite the development of these potentially high-impact therapeutics.” “We are thrilled Dr. Langer has agreed to join our SAB thus expanding our thought leadership,” added Shahin Gharakhanian, MD, acting Chief Medical Officer and SAB Chair of Decoy. “We look forward to synergizing his guidance with our current SAB members and incorporating his drug design perspectives, particularly calling upon his expertise in developing dosage forms and routes of administration for Decoy’s peptide-conjugate drugs.” Dr. Langer is one of nine Institute Professors at MIT, the institution’s highest faculty honor, and is a faculty member of the Harvard-MIT program in Health Sciences and Technology. His pioneering work has benefited millions of people worldwide and includes isolating the first angiogenesis inhibitors (with Dr. Judah Folkman) leading to new treatments for cancer and blindness. He also created the first nanoparticles and microparticles for delivering large molecules including nucleic acids, and helped establish the field of tissue engineering, which enabled artificial skin for burn victims and organ-on-a-chip technology. Dr. Langer has authored more than 1,600 scientific papers with more than 444,000 citations, making him the most-cited biological engineer in history. His patents have been licensed or sublicensed to over 400 companies and he has co-founded more than 40 ventures. Dr. Langer chaired the FDA’s Science Board from 1999–2002. He has received more than 220 awards and is one of only three living individuals to receive both the U.S. National Medal of Science and the National Medal of Technology and Innovation. His accolades include the Draper Prize, the Queen Elizabeth Prize for Engineering, the Albany Medical Center Prize, the Breakthrough Prize in Life Sciences, the Kyoto Prize, the Wolf Prize in Chemistry, the Millennium Technology Prize and the Kavli Prize in Nanoscience. He holds 44 honorary doctorates from institutions including Harvard University, Yale University, Columbia University and the University of Oxford, and has been elected to the National Academies of Medicine, Engineering and Sciences, as well as the National Academy of Inventors. About Decoy’s Peptide Conjugate Technology Decoy’s drug design engine uses the power of computational tools and fast peptide synthesis technology pioneered in the laboratory of Brad Pentelute, Ph.D., Professor of Chemistry at MIT and Decoy co-founder, to rapidly engineer and synthesize novel antivirals that directly target highly conserved viral machinery. Its proprietary IMP3ACT peptide conjugate drug design and manufacturing platform leverages machine learning and artificial intelligence (AI) tools. IMP3ACT allows for the rapid computational design and manufacturing of innovative peptide-conjugate therapeutics including rapid response to novel viral pathogens including H5N1 avian flu. Peptide conjugates are a new class of drug, perhaps best known for the popular diabetes and weight loss medications, that takes advantage of the strong activity and selectivity of peptides, and improves their targeting and durability by adding a lipid molecule. Decoy Therapeutics is expanding the use of this new drug class to indications including infectious diseases and cancer. The IMP3ACT platform leverages peptide chemistry to design a-helical peptides using computational and machine learning tools. These peptides are transformed into multimeric conjugates by chemically linking a defined number of copies to lipids or other suitable membrane anchor moieties, enhancing their drug-like properties and dosing flexibility with extended pharmacokinetics. Decoy’s technology has produced peptide conjugates effective in vitro against multiple human coronaviruses, including all SARS-CoV-2 major variants of concern to date, and against RSV A, RSV B and hPIV3, and in vivo against the SARS-CoV-2 delta variant. By integrating machine learning algorithms in peptide design and synthesis, Decoy’s platform accelerates the creation of lead molecules for preclinical evaluations, simultaneously optimizing peptide conjugates for enhanced affinity, binding specificity, resistance to proteases, pharmacokinetic properties and manufacturability at early commercial scale. About Decoy Therapeutics, Inc. Decoy Therapeutics is a preclinical-stage biotechnology company that is leveraging machine learning and artificial intelligence tools alongside high-speed synthesis techniques to rapidly design, engineer and manufacture peptide-conjugate drug candidates that target serious unmet medical needs. The company’s initial pipeline is focused on respiratory viruses and GI cancers. Decoy has attracted financing from institutional investors as well as significant non-dilutive capital from the Massachusetts Life Sciences Seed Fund, the Google AI startup program and the NVIDIA Inception program among other sources. The company has also received QuickFire Challenge award funding provided by the Biomedical Advanced Research and Development Authority (BARDA) through BLUE KNIGHT™, a collaboration between Johnson & Johnson Innovation – JLABS and BARDA within the Administration for Strategic Preparedness and Response. For more information, please visit www.DecoyTx.com. About Salarius Pharmaceuticals, Inc. Salarius Pharmaceuticals is a clinical-stage biopharmaceutical company with two drug candidates for patients with cancer in need of new treatment options. Salarius’ product portfolio includes seclidemstat, the company’s lead candidate, which is being studied in an investigator-initiated Phase 1/2 clinical study in hematologic cancers underway at MD Anderson Cancer Center as a potential treatment for MDS and CMML in patients with limited treatment options. SP-3164, the company’s IND-stage second asset, is an oral small molecule protein degrader. Salarius previously received financial support for seclidemstat for the treatment of Ewing sarcoma from the National Pediatric Cancer Foundation and was a recipient of a Product Development Award from the Cancer Prevention and Research Institute of Texas (CPRIT). For more information, please visit www.salariuspharma.com. About the Proposed Transaction Definitive agreements were executed with unanimous approvals by the Boards of Directors of Salarius and Decoy. The closing consideration will consist primarily of nonvoting preferred stock of Salarius, and it is expected that following closing and a post-closing stockholder vote to approve the conversion of the preferred shares into common stock, Decoy investors would own approximately 86% of the outstanding shares of the merged company and Salarius stockholders would own approximately 14% of the outstanding shares, in each case exclusive of any shares issued in any financing, including the qualifying financing(s) necessary to consummate the merger transaction. For further details on the transaction and conditions for closing of the merger, please refer to the Form 8-Ks Salarius filed with the U.S. Securities and Exchange Commission (SEC) on each of January 13, 2025 and March 8, 2025 at www.sec.gov. Non-Solicitation This communication shall not constitute an offer to sell or the solicitation of an offer to sell or the solicitation of an offer to buy any securities, nor shall there be any sale of securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. No public offer of securities in connection with the merger shall be made except by means of a prospectus meeting the requirements of Section 10 of the Securities Act of 1933, as amended. Forward-Looking Statements This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 regarding Salarius, Decoy, the proposed merger and other matters, including without limitation, statements relating to plans and expectations relating to the business, scientific advisory board, products, including expected achievement of milestones for its lead asset and future prospects of Decoy and the combined company. These statements may discuss goals, intentions and expectations as to future plans, trends, events, results of operations or financial condition, or otherwise, based on current beliefs of the management of Salarius, as well as assumptions made by, and information currently available to, management. Forward-looking statements generally include statements that are predictive in nature and depend upon or refer to future events or conditions, and include words such as “may,” “will,” “should,” “would,” “expect,” “anticipate,” “plan,” “likely,” “believe,” “estimate,” “project,” “intend,” and other similar expressions. Statements that are not historical facts are forward-looking statements. Forward-looking statements are based on current beliefs and assumptions that are subject to risks and uncertainties and are not guarantees of future performance. Actual results could differ materially from those contained in any forward-looking statement as a result of various factors, including, without limitation: the risk that the conditions to the closing are not satisfied, including uncertainties as to the timing of the consummation of the proposed merger; the ability of each of Salarius and Decoy to consummate the merger; risks related to Salarius’ ability to estimate and manage its operating expenses and its expenses associated with the proposed merger pending the closing; risks that the combined company will not achieve the synergies expected from the proposed merger; risks that Salarius and the combined company will not obtain sufficient financing to execute on their business plans and risks related to Decoy’s products and development plans, including unanticipated issues with any IND application process and the potential of the IMP3ACT™ platform. Readers are urged to carefully review and consider the various disclosures made by Salarius in its reports filed with the SEC, including its Annual Report on Form 10-K for the fiscal year ended December 31, 2024, as revised or supplemented by its Quarterly Reports on Form 10-Q and other documents filed with the SEC. If one or more of these risks or uncertainties materialize, or if the underlying assumptions prove incorrect, Salarius’ actual results may vary materially from those expected or projected. CONTACTS: Decoy Therapeutics, Inc.Rick Pierce, CEOPierce@decoytx.com617-447-8299 Business Development:Peter Marschel, CBOPeter@Decoytx.com617-943-6305 Salarius Pharmaceuticals, Inc.Alliance Advisors IRJody Cainjcain@allianceadvisors.com310-691-7100

BASKING RIDGE, N.J., April 15, 2025 (GLOBE NEWSWIRE) -- Lisata Therapeutics, Inc. (Nasdaq: LSTA) (“Lisata” or the “Company”), a clinical-stage pharmaceutical company developing innovative therapies for the treatment of advanced solid tumors and other serious diseases, today announced that the Company has entered into a research license with Catalent, Inc. (“Catalent”) to evaluate, in a preclinical setting, the efficacy of Lisata's iRGD cyclic peptide product candidate, certepetide, as a payload used in the context of Catalent’s SMARTag® antibody-drug conjugate (“ADC”) dual-payload technology platform for the treatment of difficult-to-treat-diseases, including advanced solid tumors. Under the terms of the agreement, Catalent will assume full responsibility for all research and development expenses and Lisata will provide consulting support. Further, Lisata will receive an upfront payment with the possibility of future considerations contingent upon the results of the preclinical evaluation. “This is another obvious step in the development of Lisata and certepetide as we see great potential in combining both the technologies and the talents of the scientific teams at Lisata and Catalent to study the combination of certepetide and the SMARTag® ADC platform. While ADCs utilize monoclonal antibodies to target tumor-specific antigens ensuring precise delivery of cytotoxic drugs to cancer cells while sparing healthy tissues, combining ADC’s with certepetide should ensure that the targeted payload penetrates the tumor. The combination of ADCs and certepetide could revolutionize precision oncology delivering targeted therapies deep within tumors for improved efficacy with reduced systemic toxicity. Additionally, the presence of certepetide in the tumor microenvironment (TME) is expected to reduce the immunosuppressive nature of the TME further improving patient response and outcomes to the ADC therapy.” stated Kristen K. Buck, M.D., Executive Vice President of Research and Development and Chief Medical Officer of Lisata. “This agreement furthers our strategy of exploiting certepetide’s broad applicability and unlocking its full potential. We look forward to seeing results in the near future.” “We are excited to partner with Lisata to investigate how certepetide and the SMARTag® technology might be used together to make ADCs with enhanced functions,” stated Penelope Drake, Head of R&D, Bioconjugates at Catalent. “We are enthusiastic about the potential of this collaboration to deliver innovative treatment options.” About Lisata Therapeutics Lisata Therapeutics is a clinical-stage pharmaceutical company dedicated to the discovery, development and commercialization of innovative therapies for the treatment of advanced solid tumors and other major diseases. Lisata’s cyclic peptide product candidate, certepetide, is an investigational drug designed to activate a novel uptake pathway that allows co-administered or tethered anti-cancer drugs to selectively target and penetrate solid tumors more effectively. Lisata has already established noteworthy commercial and R&D partnerships based on its CendR Platform® technology. The Company expects to announce numerous milestones over the next 1.5 years and believes that its projected capital will fund operations into the second quarter of 2026, encompassing anticipated data milestones from its ongoing and planned clinical trials. Learn more about certepetide’s mechanism of action in our short film. For more information on the Company, please visit www.lisata.com. About Certepetide Certepetide (formerly LSTA1), an internalizing RGD (arginylglycylaspartic acid or iRGD), cyclic peptide product candidate, is an investigational drug designed to activate a novel uptake pathway that allows co-administered or tethered anti-cancer drugs to target and penetrate solid tumors more effectively. Certepetide actuates this active transport system in a tumor-specific manner, resulting in systemically co-administered anti-cancer drugs more efficiently penetrating and accumulating in the tumor. Certepetide also has been shown to modify the tumor microenvironment resulting in tumors which are more susceptible to immunotherapies. We and our collaborators have amassed significant non-clinical data demonstrating enhanced delivery of a range of emerging anti-cancer therapies, including immunotherapies and RNA-based therapeutics. To date, certepetide has also demonstrated favorable safety, tolerability, and clinical activity in completed and ongoing clinical trials designed to test its ability to enhance the effectiveness of standard-of-care chemotherapy for pancreatic cancer. Lisata is exploring the potential of certepetide to enable a variety of treatment modalities to treat a range of solid tumors more effectively. Certepetide has been awarded Fast Track designation (U.S.) and Orphan Drug Designation for pancreatic cancer (U.S. and E.U.) as well as Orphan Drug Designation for glioma (U.S.) and osteosarcoma (U.S.). Additionally, certepetide has received Rare Pediatric Disease Designation for osteosarcoma (U.S.). Forward-Looking Statements This communication contains “forward-looking statements” that involve substantial risks and uncertainties for purposes of the safe harbor provided by the Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical facts, included in this communication regarding the Company’s clinical development programs are forward-looking statements. In addition, when or if used in this communication, the words “may,” “could,” “should,” “anticipate,” “believe,” “estimate,” “expect,” “intend,” “plan,” “predict” and similar expressions and their variants, as they relate to Lisata or its management, may identify forward-looking statements. Examples of forward-looking statements include, but are not limited to, the potential of the collaboration with Catalent to develop treatment options; the potential efficacy of certepetide as a treatment for patients with solid tumors; our beliefs about the potential uses and benefits of certepetide; statements relating to Lisata’s continued listing on the Nasdaq Capital Market; expectations regarding the capitalization, resources and ownership structure of Lisata; the approach Lisata is taking to discover and develop novel therapeutics; the adequacy of Lisata’s capital to support its future operations and its ability to successfully initiate and complete clinical trials; and the difficulty in predicting the time and cost of development of Lisata’s product candidates. Actual results could differ materially from those contained in any forward-looking statement as a result of various factors, including, without limitation: results observed from a single patient case study are not necessarily indicative of final results and one or more of the clinical outcomes may materially change following more comprehensive reviews of the data and as more patient data becomes available, including the risk that unconfirmed responses may not ultimately result in confirmed responses to treatment after follow-up evaluations; the risk that product candidates that appeared promising in early research and clinical trials do not demonstrate safety and/or efficacy in larger-scale or later clinical trials; the safety and efficacy of Lisata’s product candidates, decisions of regulatory authorities and the timing thereof, the duration and impact of regulatory delays in Lisata’s clinical programs, Lisata’s ability to finance its operations, the likelihood and timing of the receipt of future milestone and licensing fees, the future success of Lisata’s scientific studies, Lisata’s ability to successfully develop and commercialize drug candidates, the timing for starting and completing clinical trials, rapid technological change in Lisata’s markets, the ability of Lisata to protect its intellectual property rights; and legislative, regulatory, political and economic developments. The foregoing review of important factors that could cause actual events to differ from expectations should not be construed as exhaustive and should be read in conjunction with statements that are included herein and elsewhere, including the risk factors included in Lisata’s Annual Report on Form 10-K filed with the SEC on February 27, 2025, and in other documents filed by Lisata with the Securities and Exchange Commission. Except as required by applicable law, Lisata undertakes no obligation to revise or update any forward-looking statement, or to make any other forward-looking statements, whether as a result of new information, future events, or otherwise. Lisata Therapeutics Contact: Investors: Lisata Therapeutics John Menditto Vice President, Investor Relations and Corporate Communications Phone: 908-842-0084 Email: jmenditto@lisata.com Media: ICR Healthcare Elizabeth Coleman Account Supervisor Phone: 203-682-4783 Email: elizabeth.coleman@icrhealthcare.com This press release was published by a CLEAR® Verified individual.