Barrett Esophagus

Highlights Continued Progress in Early Detection and the Progression of Esophageal Disease SUFFERN, N.Y., May 2, 2025 /PRNewswire/ -- CDx Diagnostics announced today that new clinical data supporting the utility of the WATS3D test for Barrett's esophagus and dysplasia screening and surveillance has been selected for podium presentation at the 2025 Digestive Disease Week (DDW) in San Diego, the premier conference for gastroenterology professionals. This podium presentation, along with additional data featured in a separate poster presentation, highlights WATS3D's vital role in early detection, progression monitoring and risk assessment of patients at risk for Barrett's esophagus and esophageal cancer. Continue Reading WATS3D has consistently shown superior detection rates compared to conventional forceps biopsy (FB), the latter of which can miss up to 50% of cases. By sampling a broader area of mucosa and analyzing more cellular material using advanced 3D imaging, WATS3D may help gastroenterologists detect Barrett's esophagus that might otherwise go undiagnosed. New DDW 2025 data reveal WATS3D's enhanced capabilities for Barrett's detection, surveillance and risk assessment. Post this Key Events at DDW 2025: Podium Presentation: "Progression Rates of Barrett's Esophagus and Dysplasia Detected by WATS3D Are Similar to Those Diagnosed by Forceps Biopsies" Poster Presentation: "MUC2 Immunostaining Predicts Neoplastic Progression as Accurately as the Presence of Goblet Cells in Columnar-Lined Esophagus: A WATS3D Study of 3,553 Patients" Nicholas J. Shaheen, MD will deliver the podium presentation, based on a collaborative study with Dr. Michael Smith, Dr. Vivek Kaul, Mendel Singer Ph.D., and Dr. Robert Odze. "The findings validate WATS3D's role in early detection," said Dr. Shaheen. "We're excited to share these results at DDW and discuss their impact on patient care." Robert D. Odze, MD noted that "These studies advance our understanding of the biological significance of WATS3D detected lesions and their risk of progression to cancer in Barrett's esophagus." The new data shared at DDW 2025 from May 3-6 offers important clinical insights into the evolving role of WATS3D in Barrett's detection, surveillance and risk assessment. For more information, visit or contact us at [email protected]. About CDx Diagnostics CDx Diagnostics' mission is to Empower Physicians with Innovative Technology to Prevent Esophageal Cancer, One Patient at a Time. The company's proprietary diagnostic platform combines advanced computer imaging, artificial intelligence, molecular biology, and 3D cytopathology to detect precancerous changes earlier and more precisely than conventional methods. This pioneering solution has analyzed over 400,000 cases, empowering providers to identify those requiring early intervention, reduce time to treatment, and improve outcomes by detecting disease that might be missed by traditional forceps biopsies. CONTACT: Logan Garrett [email protected] 423-519-9979 SOURCE CDx Diagnostics WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

April 08, 2025 -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, is supporting key educational programs and initiatives throughout the month of April in recognition of Esophageal Cancer Awareness Month. The Company is proudly collaborating with the Esophageal Cancer Action Network (ECAN), the American Foregut Society (AFS) and The Gut Doctor PodcastLLC to promote esophageal cancer prevention, education and advocacy. “As esophageal cancer is often diagnosed in its late stages, its five-year survival rate remains alarmingly low at around 20%,”1 said Emmanuel Gorospe, M.D., board-certified gastroenterologist and medical director, gastroenterology, of Castle Biosciences. “This makes early detection and prevention critical. Through our collaboration with advocacy groups and the gastrointestinal (GI) community, we are committed to raising awareness of esophageal cancer risk factors and providing meaningful support to patients and healthcare professionals alike.” Detection of esophageal cancer and its precursor, Barrett's esophagus (BE), presents significant challenges because the main symptoms — heartburn and gastroesophageal reflux disease (GERD) —commonly occur in many less serious conditions that typically don't warrant concern. Doctors have very good methods to eliminate precancerous cells in BE patients at risk of developing cancer. The challenge, however, is finding which BE patients among the 1.5 million in the U.S. with the condition are in the 0.5% who will progress to cancer. TissueCypher® is Castle’s risk-stratification test for patients with BE designed to predict a patient’s individual risk of progression to high-grade dysplasia or esophageal cancer. Knowing which patients are likely to progress to cancer can help physicians treat them earlier, potentially creating an opportunity to save their lives. Castle is collaborating with ECAN through a dedicated Esophageal Cancer Awareness Month sponsorship that encompasses a digital media campaign and awareness kits containing brochures, posters and wrist bands that will be distributed to ECAN supporters seeking to raise awareness about esophageal cancer. The media campaign will emphasize several key points: 1) the link between reflux and cancer, 2) esophageal cancer is preventable, and 3) new technology creates vast opportunities to save lives, particularly in the areas of screening/detection, risk stratification, diagnostics and treatment. Additionally, the campaign will focus on human interest stories featuring those who have been affected by esophageal cancer and experienced this alarming diagnosis. “Awareness is key to ending this devastating disease that is the fastest increasing cancer diagnosis in American men today and has tripled among young people in recent decades,”2,3 said Mindy Mintz Mordecai, founder, president and chief executive officer of ECAN. “The heart of our mission at ECAN is to save lives, and we are grateful for the support of our corporate partners and our many supporters who help us carry out this mission through education, prevention and awareness initiatives.” Castle teamed up with the American Foregut Society (AFS) for a special All Fore Guts! podcast episode, AFS Celebrates Esophageal Cancer Awareness Month — GET SCREENED, which launched April 1. Moderated by AFS President and Co-Founder Dan Lister, M.D., FACS, FAFS, the episode features a discussion with ECAN’s Mordecai and John C. Lipham, M.D., chairman of ECAN’s board of directors, chief of the division of upper GI and general surgery, and professor of surgery at the Keck School of Medicine of USC, highlighting the importance of esophageal cancer screening. Listen to the episode on the American Foregut Society’s website or stream it on Spotify. Hosted by Neil D. Parikh, M.D., a community gastroenterologist in Connecticut, The Gut Doctor Podcast provides general education around common gut-related topics through engaging conversations with gastroenterological specialists. For an April episode, Castle collaborated with Parikh and J. George Sun, M.D., a gastroenterologist with Digestive Health Associates in Houston, to discuss esophageal cancer, common risk factors and treatment to raise awareness around the disease. The episode will be available at The Gut Doctor Podcast and through major podcast streaming platforms. The Esophageal Cancer Action Network (ECAN) is a non-profit, 501 (c)(3) organization supporting esophageal cancer patients and their families. ECAN started Esophageal Cancer Awareness Month in 2009 in support of its mission to save lives by 1) promoting early detection by increasing awareness about the link between reflux disease and cancer, 2) supporting medical innovation to prevent, detect, treat and cure esophageal cancer and 3) providing patients and families with the latest, most reliable medical information and compassionate support. ECAN’s relentless advocacy has increased the federal budget for Esophageal Cancer research by more than $20 million in the past four years, and millions more is expected in the years to come. Visit https://ecan.org/ for more information. Hosted by the American Foregut Society (AFS), the All Fore Guts! Podcast brings gastroenterologists and surgeons together to discuss common foregut conditions. Episodes can be found on the AFS website or on Spotify. AFS is the only society where GIs and surgeons collaborate to personalize treatment and improve patient outcomes in foregut disease. Visit https://www.americanforegutsociety.org/ for more information. The Gut Doctor Podcast is hosted by Neil D. Parikh, M.D., a community gastroenterologist in Connecticut, and discusses common gut topics in a patient-friendly manner. Dr. Parikh interviews fellow GI specialists to provide a better understanding for the general public and medical providers and also features episodes on food as medicine as the worlds of culinary medicine and gastrointestinal health intertwine. Access episodes online at https://thegutdoctor.buzzsprout.com/ and via various podcast streaming platforms. Castle Biosciences (Nasdaq: CSTL) is a leading diagnostics company improving health through innovative tests that guide patient care. The Company aims to transform disease management by keeping people first: patients, clinicians, employees and investors. Castle’s current portfolio consists of tests for skin cancers, Barrett’s esophagus, mental health conditions and uveal melanoma. Additionally, the Company has active research and development programs for tests in these and other diseases with high clinical need, including its test in development to help guide systemic therapy selection for patients with moderate-to-severe atopic dermatitis seeking biologic treatment. To learn more, please visit www.CastleBiosciences.com and connect with us on LinkedIn, Facebook, X and Instagram. DecisionDx-Melanoma, DecisionDx-CMSeq, i31-SLNB, i31-ROR, DecisionDx-SCC, MyPath Melanoma, DiffDx-Melanoma, TissueCypher, IDgenetix, DecisionDx-UM, DecisionDx-PRAME and DecisionDx-UMSeq are trademarks of Castle Biosciences, Inc. 1. Center for Cancer Research at the National Cancer Institute (National Institutes of Health); https://www.cancer.gov/pediatric-adult-rare-tumor/rare-tumors/rare-digestive-system-tumors/esophageal; accessed 3/26/25 2. Esophageal Cancer Action Network; https://ecan.org/; accessed 3/26/25 3. Mayo Clinic: Young-onset esophageal adenocarcinoma: Results from a population-based study; https://www.mayoclinic.org/medical-professionals/digestive-diseases/news/young-onset-esophageal-adenocarcinoma-results-from-a-population-based-study/mac-20511018; accessed 3/26/25 The content above comes from the network. if any infringement, please contact us to modify.

VADUZ, Liechtenstein, April 10, 2025 /PRNewswire/ -- Implantica AG (publ.), a MedTech company at the forefront of introducing advanced technology into the body, including the unique device RefluxStop™ for the treatment of acid reflux, a treatment field with 1 billion sufferers, announces a new article from Germany in the well-respected Journal of Laparoendoscopic & Advanced Surgical Techniques showing excellent RefluxStop™ results in a real-world setting, akin to those achieved in the CE mark study. The study, 'Experience with an innovative surgical treatment option for gastroesophageal reflux disease: Results of 28 patients in a retrospective analysis,' was conducted by one of Germany's leading anti-reflux surgeons, Dr. med. Moustafa Elshafei, Chief of General and Visceral Surgery at St. Elisabethen Hospital, Frankfurt, Germany. Dr. med. Elshafei says, "I have treated thousands of patients with reflux and actively participated in the evolution of new technologies over the years. This is the first time I have witnessed a radically different approach to treating reflux disease without compressing the food passageway and restoring the natural anatomy of not just the sphincter muscle but also the complete gastric anatomy and physiology. This is what really drives such excellent outcomes with the RefluxStop procedure." Dr. Elshafei continues, "All cases of preoperative heartburn, regurgitation, and dysphagia in our study were completely resolved with RefluxStop, yielding high patient satisfaction results. I am very excited to see RefluxStop filling a long-standing and crucial gap in the surgical approach, offering a comprehensive solution for patients with GERD." Founder and CEO of Implantica, Dr. Peter Forsell, says, "It's an honor to see continued excellent results from yet another leading surgeon, Dr. med. Elshafei. Knowing Dr. Elshafei's significant involvement with various technologies and getting his valuable perspective on RefluxStop™'s unique and superior mechanism of action is truly encouraging." Dr. Forsell goes on to say, "GERD is a serious problem in Germany. In addition to causing chronic pain for countless patients, the disease costs the country an estimated €688 million annually in lost gross domestic product due to decreased productivity from the impact of GERD on the German workforce¹. A new and reliable surgical treatment for GERD is urgently needed. This study shows RefluxStop™ is a very safe and reliable procedure. It's clear RefluxStop™ is leading the way to a new paradigm in the surgical treatment of GERD in Germany." 1. Willich SN, Nocon M, Kulig M, et al. Cost-of-disease analysis in patients with gastro-oesophageal reflux disease and Barrett's mucosa. Aliment Pharmacol Ther. 2006;23(3):371-6; doi: 10.1111/j.1365-2036.2006.02763.x. For further information, please contact: Nicole Pehrsson, Chief Corporate Affairs Officer Telephone (CH): +41 (0)79 335 09 49 [email protected] Implantica is listed on Nasdaq First North Premier Growth Market in Stockholm. The company's Certified Adviser is FNCA Sweden AB, [email protected] The information was sent for publication, through the agency of the contact person set out above, on April 10, 2025, at 08:00 a.m. (CET). About Implantica Implantica is a medtech group dedicated to bringing advanced technology into the body. Implantica's lead product, RefluxStop™, is a CE-marked implant for the prevention of gastroesophageal reflux that will potentially create a paradigm shift in anti-reflux treatment as supported by successful clinical trial results. Implantica also focuses on eHealth inside the body and has developed a broad, patent protected, product pipeline based partly on two platform technologies: an eHealth platform designed to monitor a broad range of health parameters, control treatment from inside the body and communicate to the caregiver on distance and a wireless energizing platform designed to power remote-controlled implants wirelessly through intact skin. Implantica is listed on Nasdaq First North Premier Growth Market (ticker: IMP A SDB). Visit for further information. About RefluxStop™ RefluxStop™ is a new innovative treatment that has the potential to spur a paradigm shift in anti-reflux surgery. It's unique mechanism of action differentiates it from standard of care and current surgical solutions. Longer established surgical options for GORD involve encircling the food passageway to support the lower oesophageal sphincter's closing mechanism and are commonly associated with side effects such as swallowing difficulties, pain when swallowing and inability to belch and/or vomit. In contrast, the RefluxStop™ device treats the cause of acid reflux without encircling and putting pressure on the food passageway. It restores and maintains the lower oesophageal sphincter in its original, natural position. The RefluxStop™ mechanism of action is focused on reconstructing all three components of the anti-reflux barrier, that if compromised could possibly result in acid reflux. It restores and supports the natural anatomical physiology of the body allowing the body to itself solve the problem with acid reflux. Newsroom Community Media Contact: Implantica AG Juanita Eberhart, VP Marketing & Advocacy M: +1 925-381-4581 [email protected] This information was brought to you by Cision The following files are available for download: WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED