B. pertussis OMV Vaccine (Delonix Bioworks)

A review.The research of Copland et al. (2007) entitled "Monoclonal antibody-mediated CD200 receptor signalling suppresses macrophage activation and tissue damage in exptl. autoimmune uveoretinitis (EAU)" is reviewed with commentary and referencesCopland et al. used their model of exptl. autoimmune uveoretinitis (EAU) to demonstrate that the administration of a CD200 receptor (CD200R) agonist antibody can suppress macrophage activation and greatly diminish disease.The agonist antibody used in the current study, a monoclonal rat anti-mouse CD200R antibody called DX109, exerts its effects on EAU by delivering a neg. signal to macrophages normally provided by CD200, which in turn may lead to the suppression of interferon-y-mediated interleukin-6 and nitric oxide production during the inflammatory response.It will be exciting to determine whether the DX109 agonist antibody can lessen pathol. for other diseases in which macrophages are thought to play a primary role.