[Translation] A phase I clinical study to evaluate the safety, tolerability and pharmacokinetic properties of PZH2108 tablets in healthy Chinese subjects, with single-center, randomized, double-blind, placebo-controlled, single-ascending dosing, multiple dosing and food effects
1)评估健康成人单次口服、多次口服PZH2108片的安全性和耐受性;
2)评估健康成人单次/多次口服PZH2108片的药代动力学(PK)特征及进食对健康成人单次口服PZH2108片PK的影响;
3)探索研究口服PZH2108片对于冷刺激疼痛(PD)的影响。
[Translation] 1) Evaluate the safety and tolerability of single and multiple oral administration of PZH2108 tablets in healthy adults;
2) Evaluate the pharmacokinetic (PK) characteristics of single/multiple oral administration of PZH2108 tablets in healthy adults and the effect of food on the PK of single oral administration of PZH2108 tablets in healthy adults;
3) Explore the effect of oral administration of PZH2108 tablets on cold pain (PD).