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Last update 30 Jan 2026
Recombinant Human nsIL12 Oncolytic Adenovirus(VacV Biotheraputics)
Last update 30 Jan 2026
Overview
Basic Info
Drug Type Oncolytic virus |
Synonyms Ad-TD-nsIL12, BioTTT001 |
Target |
Action stimulants |
Mechanism IL-12R stimulants(Interleukin-12 receptor stimulants) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
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Related
8
Clinical Trials associated with Recombinant Human nsIL12 Oncolytic Adenovirus(VacV Biotheraputics)NCT06283134
A Clinical Study to Evaluate the Safety and Efficacy of Recombinant Human nsIL12 Oncolytic Adenovirus Injection (BioTTT001) in Combination With Toripalimab and Regorafenib in Patients With Liver Metastases From Colorectal Cancer
NCT07264569
Phase Ib/II Clinical Study to Evaluate the Safety, Tolerability, Biodistribution Characteristics and Preliminary Efficacy of BioTTT001 in the Treatment of Patients With Recurrent/Progressive Non-small Cell Lung Cancer
NCT07150767
A Clinical Study to Explore the Safety, Tolerability, and Efficacy of Recombinant Human nsIL12 Oncolytic Adenovirus Injection (BioTTT001) Combined With Neoadjuvant Treatment for Locally Advanced Breast Cancer
100 Clinical Results associated with Recombinant Human nsIL12 Oncolytic Adenovirus(VacV Biotheraputics)
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100 Translational Medicine associated with Recombinant Human nsIL12 Oncolytic Adenovirus(VacV Biotheraputics)
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100 Patents (Medical) associated with Recombinant Human nsIL12 Oncolytic Adenovirus(VacV Biotheraputics)
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100 Deals associated with Recombinant Human nsIL12 Oncolytic Adenovirus(VacV Biotheraputics)
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Metastatic Malignant Neoplasm to the Leptomeninges | Phase 2 | China | 25 Jun 2025 | |
| Non-Small Cell Lung Cancer | Phase 2 | China | 25 Jun 2025 | |
| High grade glioma | Phase 2 | China | 26 Nov 2024 | |
| Recurrent Malignant Glioma | Phase 2 | China | 26 Nov 2024 | |
| Metastatic Gastric Carcinoma | Phase 2 | - | 02 Apr 2024 | |
| Secondary malignant neoplasm of peritoneum | Phase 2 | - | 02 Apr 2024 | |
| Colorectal Liver Metastases | Phase 1 | - | 01 Mar 2026 | |
| Metastatic Colorectal Carcinoma | Phase 1 | - | 01 Mar 2026 | |
| Locally advanced breast cancer | Phase 1 | China | 26 Mar 2025 | |
| Colorectal Cancer | Phase 1 | China | 07 May 2024 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Phase 1 | Peritoneal Neoplasms CA125 levels | 9 | BioTTT001 5×10^9vp | bfqwlvawqi(rnyuizsank) = ugoevehwsk pvcuatnffq (culvsxycnx ) View more | Positive | 30 May 2025 | |
BioTTT001 5×10^10vp | bfqwlvawqi(rnyuizsank) = wkasnpamtm pvcuatnffq (culvsxycnx ) View more |
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