Delving into the Latest Updates on Netilmicin Sulfate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

1-N-Ethylsisomicin, Natilmicin Sulfate, Natilmicin Sulfate and Glucose

+ [46]

Target

30S subunit

Action

inhibitors

Mechanism

30S subunit inhibitors(30S ribosomal subunit inhibitors)

Therapeutic Areas

Infectious Diseases

Active Indication

Bacterial Infections

Inactive Indication-

Originator Organization

Schering-Plough Canada, Inc.

Active Organization

Livzon Group Fuzhou Fuxing Pharmaceutical Co., Ltd.

Inactive Organization

Schering Corp.

License Organization-

Drug Highest PhaseApproved

First Approval Date

United States (28 Feb 1983),

Bacterial Infections

Regulation-

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Structure/Sequence

Molecular FormulaC42H92N10O34S5

InChIKeyAGFWIZQEWFGATK-UNZHCMSXSA-N

CAS Registry56391-57-2

The duration of treatment of community acquired pulmonary infection varies between 5 and 14 days according to the authors (22), or even 3 days with new drugs having long half-life (2). For nosocomial pulmonary infection, treatment durations are not standardized (5). It is simply mentioned the concept of "usual" treatment of at least 15 days. However, recent studies used 10 days of treatment without significant decrease in the rate of healing compared to usual treatment. It is essential to clarify the optimal duration of antibiotic treatment. Indeed, any excessive extension of treatment may increase the occurrence of adverse effects (renal toxicities, hepatic...), and induce resistance of bacteria to antibiotics (selection pressure), colonization of the patient by Multiresistant bacteria and an increase in the cost of treatment

Start Date01 Jan 1998

Sponsor / Collaborator

Centre Hospitalier Universitaire de Besancon

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100 Clinical Results associated with Netilmicin Sulfate

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100 Translational Medicine associated with Netilmicin Sulfate

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100 Patents (Medical) associated with Netilmicin Sulfate

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3,337

Literatures (Medical) associated with Netilmicin Sulfate

01 Oct 2025·Journal of Computational Biophysics and Chemistry

Utilizing Non-β-Lactam Antibiotics to Combat Antimicrobial Resistance by Targeting Multiple Virulence Factors of Pseudomonas aeruginosa

Author: Arshad, Mohammed ; Parveen, Nagma ; Husain, Fohad Mabood ; Furkan, Mohammad ; Khan, Altaf ; Qais, Faizan Abul ; Khan, Rizwan Hasan ; Ahmad, Iqbal ; Adil, Mohd

In pre-antibiotic times, various highly contagious diseases like cholera, smallpox and tuberculosis were widespread worldwide. Penicillin discovery in the late 1920s was a groundbreaking moment in medical history, saving countless lives. However, over the next few decades, microbes developed antibiotic resistance, leading to a global public health threat known as antimicrobial resistance (AMR). Pseudomonas aeruginosa is a major contributor to hospital-acquired infections, affecting millions of patients and causing numerous deaths annually. Several non-[Formula: see text]-lactam antibiotics combat these infections effectively, while their effect on P. aeruginosa quorum sensing (QS) has been insufficiently explored. We have undertaken comprehensive research to understand the effect of non-[Formula: see text]-lactam antibiotics on various targets of P. aeruginosa. Using molecular simulations, we scrutinize these antibiotics” dynamic behavior and stability. Based on toxicity, binding energy and binding site, platensimycin and sulfasalazine were identified as promising candidates against various targets of P. aeruginosa. The binding energies for sulfasalazine and platensimycin with LasA were found to be −8.1 and −8.6 kcal/mol, respectively. Both of these leading antibiotics were interacting at the active sites of all tested proteins (LasA, LasI and PqsR). The examination of molecular dynamics confirmed the stable complex formation of the lead non-[Formula: see text]-lactam antibiotics with all selected target proteins under normal physiological conditions. These findings emphasize the potential efficacy of platensimycin and sulfasalazine. They could potentially be repurposed for targeting the QS of P. aeruginosa.

01 Aug 2025·BIOMEDICAL CHROMATOGRAPHY

A Simple Eco-Friendly Stability-Indicating HPLC Method for Determination of NETILMICIN in Bulk and Ophthalmic Solution.

Article

Author: Ellatif, Mohamed Abd ; Zaki, Mohamed Samir Ahmed ; Mallick, Ayaz Khurram ; Darwish, Wageh Sobhy ; Patel, Ayyub Ali ; Ahsan, Marya ; Salih, Ali GadKarim A ; Darwish, Ahmed Sobhy

The aim of our study was the development and validation of an eco-friendly stability-indicating method for the determination of netilmicin in bulk and in ophthalmic solution. The mobile phase was composed of 40-mL ethanol and 960-mL buffer solution at a pH of 3.5, which was prepared by using 1-hexane sodium sulfonate and anhydrous sodium sulfate, at a flow rate of 1 mL/min. The detecting wavelength was 205 nm, the injection volume was 20 μL, the analysis runtime was < 7 min, and the focus was on netilmicin concentration levels of 125.0-1000.0 μg/mL. The method's environmental friendliness was demonstrated by the conclusional AES of 87, the AGREE of 0.65, the MoGAPI of 76 with six green pieces, the BAGI score of 77.5, and the whiteness of 99.2. The method that is being provided demonstrates exceptional attributes including cost-effectiveness, ICH validation items, and environmental friendliness.

01 Aug 2025·EXPERIMENTAL EYE RESEARCH

Whole genome sequencing-based prediction of antibiotic-resistance of ocular Staphylococcus aureus across six continents

Article

Author: Shen, Jiawei ; Yasir, Muhammad ; Willcox, Mark

Staphylococcus aureus is a leading cause of ocular infections, resulting in vision loss in severe cases. Understanding the antibiotic resistance profiles of ocular S. aureus can help customize treatments. However, there is a lack of global data on the resistance patterns of ocular isolates and comparative regional analyses. Hence, WGS data from 195 ocular S. aureus isolates across six continents were analysed to identify antibiotic resistance genes (ARGs) and predict antibiotic resistance phenotypes in this study. A total of 40 ARGs were detected, involving resistance mechanisms against aminoglycosides, beta-lactams, macrolide-lacosamide-streptogramin B (MLS_B), glycopeptides, tetracyclines, other antibiotic classes, and efflux pump regulators. Notably, the prevalences of ARGs associated with efflux pump regulators and beta-lactams were particularly high (>80 %). Resistance to 45 antibiotics was predicted across the isolates, with 51 % identified as multidrug-resistant (MDR), while only 8 % were predicted to be fully susceptible to all predicted antibiotics. Regional data varied, with isolates from North America and Asia exhibiting the most extensive resistance patterns, showing predicted resistance to 45 and 41 antibiotics, respectively. In contrast, Oceanian isolates were predicted to be resistant to only 14 antibiotics. Beta-lactams showed the highest predicted resistance prevalence among all antibiotic classes. Notably, North American isolates showed markedly higher resistance to MLS_B antibiotics. A high proportion of cloud genes highlights the need for monitoring regional resistance. This study provides antibiotic resistance profiles among ocular S. aureus using WGS prediction, emphasizing the importance of regional surveillance and antimicrobial stewardship to suggest effective treatment strategies. It is recommended that WGS of more strains be deposited to overcome limited data, and laboratory tests be performed to analyse the consistency between genetic predicted and phenotypic resistance.

100 Deals associated with Netilmicin Sulfate

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