Last update 29 Jun 2026

PLK1-Targeted DAC (Crossfire)

Overview

Basic Info

Drug Type
Degrader-antibody conjugates
Synonyms-
Target
PLK1
Action
degraders
Mechanism
PLK1 degraders(Polo like kinase 1 degraders)
Therapeutic Areas
NeoplasmsSkin and Musculoskeletal Diseases
Active Indication
Triple Negative Breast Cancer
Inactive Indication-
Originator Organization
Crossfire Oncology BV
Active Organization
Crossfire Oncology BV
Inactive Organization-
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Structure/Sequence

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Related

100 Clinical Results associated with PLK1-Targeted DAC (Crossfire)
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100 Translational Medicine associated with PLK1-Targeted DAC (Crossfire)
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100 Patents (Medical) associated with PLK1-Targeted DAC (Crossfire)
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100 Deals associated with PLK1-Targeted DAC (Crossfire)
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Triple Negative Breast CancerPreclinical
Netherlands
Crossfire Oncology BV
03 Apr 2026
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

No Data

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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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