Delving into the Latest Updates on VRN-10 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

VRN 10, VRN10, VRN101099

Target

HER2

Action

antagonists

Mechanism

HER2 antagonists(Receptor tyrosine-protein kinase erbB-2 antagonists)

Therapeutic Areas

NeoplasmsSkin and Musculoskeletal Diseases

Active Indication

HER2 Positive Solid TumorsHER2 Positive Breast Cancer

Inactive Indication-

Originator Organization

Voronoi, Inc.

Active Organization

Voronoi, Inc.

Inactive Organization-

License Organization-

Drug Highest PhasePhase 1

First Approval Date-

Regulation-

Login to view timeline

This Clinical trial is being done to understand how food and a common stomach-acid reducing medicine (called a proton pump inhibitor-PPI) affect how the body absorbs a new drug, VRN101099, in healthy adults.
Researchers will measure how much of the drug gets into the bloodstream and how fast it gets there in each situation.
This will help identify the most effective way for future patients to use VRN101099 in the treatment of solid tumors and cancers.
The main questions it aims to answer is:
1. Does food or a PPI change how the body absorbs a single dose of VRN101099?
2. Is a single dose of VRN101099 safe and well tolerated when taken with or without food or a PPI?
3. How is VRN101099 removed through urine when taken with or without food or a PPI?

Start Date12 May 2026

Sponsor / Collaborator

Voronoi, Inc.

NCT06806982

/ RecruitingPhase 1

A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of VRN101099 in Patients With HER2-Positive Solid Tumors

This FIH open-label study aims to investigate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and antitumor effect of VRN101099 in patients with HER2-positive solid tumors for whom no standard therapies are available.

Start Date17 Feb 2025

Sponsor / Collaborator

Voronoi, Inc.

100 Clinical Results associated with VRN-10

Login to view more data

100 Translational Medicine associated with VRN-10

Login to view more data

100 Patents (Medical) associated with VRN-10

Login to view more data

100 Deals associated with VRN-10

Login to view more data