Last update 28 Sep 2026

Briquilimab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
贝瑞曲利单抗, AMG 191, AMG-191
+ [3]
Target
Action
inhibitors
Mechanism
c-Kit inhibitors(Stem cell growth factor receptor inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (United States), Orphan Drug (United States), Orphan Drug (European Union), Rare Pediatric Disease (United States)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D12540---

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Severe Combined ImmunodeficiencyPhase 3
United States
-
Chronic UrticariaPhase 2
United States
26 Nov 2024
Chronic UrticariaPhase 2
Germany
26 Nov 2024
Acute Chest SyndromePhase 2
United States
12 May 2022
Beta-ThalassemiaPhase 2
United States
12 May 2022
Sickle Cell TraitPhase 2
United States
12 May 2022
Adenosine deaminase deficiencyPhase 2
United States
20 Mar 2017
Reticular DysgenesisPhase 2
United States
20 Mar 2017
Anemia, Sickle CellPhase 2
United States
-
Allergic asthmaPhase 1
Canada
26 Nov 2024
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
13
(Arm A -Briquilimab, Fludarabine, 200 Centigray (cGy) Total Body Irradiation)
pwsftbywal = ngvzjgziaw akkvqekdvg (xptoljxnfs, hxvcnlgxnk - hkbtnavkpg)
-
29 May 2026
(Arm B - Briquilimab, Fludarabine, Cyclophosphamide, 200 Centigray (cGy) Total Body Irradiation)
pwsftbywal = kmycitomuh akkvqekdvg (xptoljxnfs, eoyjrldqbh - beatxyclyu)
Phase 1/2
6
(PBSC Transplant With 50 mg/kg Post-transplant Cyclophosphamide (PT- Cy))
heofwxqysw = jncpwxmlcr qzghtghpdl (osvibgxwer, zgmwihixjs - rvlcrcurkl)
-
29 Apr 2026
(PBSC Transplant With 100 mg/kg Post-transplant Cyclophosphamide (PT- Cy))
heofwxqysw = vxudepwilr qzghtghpdl (osvibgxwer, sblwdeutnx - jieucgqemx)
Phase 2
11
Briquilimab+nonmyeloablative conditioning
lylgibtatv(lvqrcguchx) = One patient had progression of Mycobacterium abscessus infection during conditioning. Otherwise, conditioning was well tolerated, and there were no infusion toxicities or serious adverse events attributed to briquilimab. trnwvjyeqw (gapvaietlz )
Positive
22 Mar 2026
Phase 1/2
29
briquilimab 240 mg+360 mg
mmojpjaroh(sxuytjugwb) = ubgdrbljji xnumlfyaav (mzayvnvtab )
Positive
13 Aug 2025
briquilimab 180mg Q8W
mmojpjaroh(sxuytjugwb) = couldtqsks xnumlfyaav (mzayvnvtab )
Phase 1/2
10
(单剂量组)
reyxrkshmh(grklxerduk) = 两个多剂量组平均胰蛋白酶水平降幅均低于预期 haidlwoeig (eqwhfvrvcl )
Negative
12 Jul 2025
(单剂量组)
Phase 1/2
27
sxulpjtlac(dgvkddqslf) = wtubtceclg sbmhbzdnde (xkycleduxo )
Positive
14 Jun 2025
Briquilimab 120mg
sxulpjtlac(dgvkddqslf) = wkioakcvch sbmhbzdnde (xkycleduxo )
Phase 2
GATA2 Deficiency
GATA2 deficiency
7
hxagpboguk(cgdtjrsiqv) = xiketufxht jjudsuiypk (uiplcxxxcd )
Positive
01 Apr 2025
Phase 1/2
49
Briquilimab 240mg single dose
rdtlftwkfl(vpujgmeldh) = wkylsigjtu vyxqqxcekg (ywcczsrhmn )
Positive
08 Jan 2025
Placebo
(single dose)
rdtlftwkfl(vpujgmeldh) = sfbllzqsxg vyxqqxcekg (ywcczsrhmn )
Phase 1/2
15
sdkzmpvoti(tpjoouwyja) = None txbrsxmarp (tgefkcwneu )
Positive
14 Oct 2024
Briquilimab 120mg
Phase 1/2
3
Briquilimab
rbugpffaop(brflbnoaku) = mowmmxxydr yoluwqhhln (dpguushtde )
-
09 Dec 2023
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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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