Last update 03 Jun 2025

CLL1 and CD38 dual-target CAR-T(Gracell Biotechnology Shanghai)

Overview

Basic Info

Drug Type
CAR-T
Synonyms-
Target
CD38 x CLL-1
Action
modulators
Mechanism
CD38 modulators(Lymphocyte differentiation antigen CD38 modulators), CLL-1 modulators(C-Type lectin domain family 12 member A modulators), Immunologic cytotoxicity
Therapeutic Areas
NeoplasmsHemic and Lymphatic DiseasesOther Diseases
Active Indication
Acute Promyelocytic LeukemiaRefractory acute myeloid leukemia
Inactive Indication
Relapsing acute myeloid leukemia
Originator Organization
Gracell Biotechnologies (Shanghai) Co., Ltd.Gracell Biotechnologies (Shanghai) Co., Ltd.
Active Organization
Gracell Biotechnologies (Shanghai) Co., Ltd.Gracell Biotechnologies (Shanghai) Co., Ltd.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

2
Clinical Trials associated with CLL1 and CD38 dual-target CAR-T(Gracell Biotechnology Shanghai)
NCT06880354
/ RecruitingPhase 1IIT
A Clinical Study to Evaluate the Safety and Efficacy of CLL1 and CD38 Dual-Target CAR-T Cell Injection in the Treatment of Relapsed or Refractory Acute Myeloid Leukemia
NCT06110208
/ TerminatedEarly Phase 1IIT
Clinical Study to Evaluate the Safety and Preliminary Efficacy of CLL1 and CD38 Dual CAR-T Injection in the Treatment of Relapsed and Refractory Acute Myeloid Leukemia
100 Clinical Results associated with CLL1 and CD38 dual-target CAR-T(Gracell Biotechnology Shanghai)
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100 Translational Medicine associated with CLL1 and CD38 dual-target CAR-T(Gracell Biotechnology Shanghai)
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100 Patents (Medical) associated with CLL1 and CD38 dual-target CAR-T(Gracell Biotechnology Shanghai)
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100 Deals associated with CLL1 and CD38 dual-target CAR-T(Gracell Biotechnology Shanghai)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Promyelocytic LeukemiaPhase 1
China
Gracell Biotechnologies (Shanghai) Co., Ltd.Gracell Biotechnologies (Shanghai) Co., Ltd.
22 May 2025
Refractory acute myeloid leukemiaPhase 1
China
Gracell Biotechnologies (Shanghai) Co., Ltd.Gracell Biotechnologies (Shanghai) Co., Ltd.
22 May 2025
Relapsing acute myeloid leukemiaPhase 1
China
Gracell Biotechnologies (Shanghai) Co., Ltd.Gracell Biotechnologies (Shanghai) Co., Ltd.
10 Oct 2023
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Clinical Result

Indication
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Evaluation
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Clinical Trial

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Approval

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Regulation

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