Last update 08 May 2025

BF-844

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Target
CLRN1
Action
modulators
Mechanism
CLRN1 modulators(Clarin 1 modulators)
Therapeutic Areas
Nervous System DiseasesCongenital DisordersEye Diseases+ [2]
Active Indication
Usher Syndromes
Inactive Indication-
Originator Organization
Usher Iii Initiative , Inc.Usher Iii Initiative , Inc.
Active Organization
Case Western Reserve UniversityCase Western Reserve UniversityUsher Iii Initiative , Inc.Usher Iii Initiative , Inc.
Inactive Organization-
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Structure/Sequence

Molecular FormulaC21H19ClN4O
InChIKeyTVNSCKMVODVWRS-UHFFFAOYSA-N
CAS Registry1404506-35-9

Related

1
Clinical Trials associated with BF-844
NCT06592131
/ Not yet recruitingPhase 1
First-in-Human Phase-1, Randomised, Double-Blinded, Placebo Controlled Study to Assess Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Ascending Doses, As Well As a Food Effect Study, of BF844 When Administered Orally to Healthy Adult Participants
100 Clinical Results associated with BF-844
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100 Translational Medicine associated with BF-844
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100 Patents (Medical) associated with BF-844
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1
Literatures (Medical) associated with BF-844
01 Jun 2016Nature Chemical Biology
A small molecule mitigates hearing loss in a mouse model of Usher syndrome III
100 Deals associated with BF-844
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Usher SyndromesPreclinical
United States
Case Western Reserve UniversityCase Western Reserve University
-
Usher SyndromesPreclinical
United States
Usher Iii Initiative , Inc.Usher Iii Initiative , Inc.
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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