Sigma-Aldrich, Inc.

Controlled radical polymerization (CRP) technol. enables the production of polymers with a controlled mol. weight, narrow distribution of chain lengths, and highly specific architectures.Polymers generated through controlled radical polymerization (CRP) are broadly used in applications such as biomedical, energy, and electronics materials.The production and com. availability of RAFT agents is one set of examples of how Aldrich Materials Science is enabling the wider use of RAFT technol.Aldrich has made a variety of monomers and polymerization tools available for researchers in order to facilitate the greater use of controlled radical polymerizationThese efforts help to increase the potential for industrial adoption of CRP techniques in a number of application areas.For example, the ability to produce RAFT agents at appropriate cost still limits widespread industrial adoption.This talk will provide a background on major CRP techniques, the com. available CRP reagents, and the latest efforts and challenges of scale-up of CRP tools for use in various markets.

Though it has been in practice since the 60's, continuous flow chem. has been gaining popularity for application within the fine chem. and pharmaceutical manufacturing sector in the last decade.Synthetic chemists and process engineers are now using continuous flow microreactor technol. as a tool for reaction control and process optimization, making it possible to develop and synthesize new chem. entities from small to large scale.This article explores the increasing interest in continuous manufacturing, input from regulatory bodies, some of the challenges to implementation, and provides a look at how SAFC implemented continuous manufacturing in Buchs, Switzerland for an application to synthesize organic azide compounds