Last update 08 May 2025

GNAI2

Basic Info

Synonyms
Adenylate cyclase-inhibiting G alpha protein, G protein subunit alpha i2, GIP
+ [3]
Introduction
Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.

Related

1
Drugs associated with GNAI2
US20220340526
Patent Mining
Target
EGF x GNAI2
Mechanism
GNAI2 inhibitors
Active Org.
The Georgia Tech Research Corp.The Georgia Tech Research Corp.
Originator Org.
The Georgia Tech Research Corp.The Georgia Tech Research Corp.
Active Indication
Neoplasms
Inactive Indication-
Drug Highest PhaseDiscovery
First Approval Ctry. / Loc.-
First Approval Date20 Jan 1800
100 Clinical Results associated with GNAI2
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100 Translational Medicine associated with GNAI2
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0 Patents (Medical) associated with GNAI2
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169
Literatures (Medical) associated with GNAI2
27 Mar 2025Combinatorial Chemistry & High Throughput Screening
Exploring Mechanisms of Ephx2 in Treating Atherosclerosis Using Independent Cascade Model and Adverse Outcome Pathways
24 Jan 2025Nucleic Acids Research
RNA G-quadruplex structure-based PROTACs for targeted DHX36 protein degradation and gene activity modulation in mammalian cells
01 Dec 2024Neurological Sciences
A new variant confirms GNAI2 as a rare cause of periventricular nodular heterotopia

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