Last update 08 May 2025

PTP4A2

Basic Info

Synonyms
HU-PP-1, OV-1, PRL-2
+ [10]
Introduction
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.

Related

1
Drugs associated with PTP4A2
KVX-053
Target
PRL-3 x PTP4A2
Mechanism
PRL-3 inhibitors [+1]
Active Org.
Kevirx, Inc.Kevirx, Inc. [+3]
Originator Org.
University of VirginiaUniversity of Virginia [+1]
Active Indication
Glioblastoma [+3]
Inactive Indication-
Drug Highest PhasePreclinical
First Approval Ctry. / Loc.-
First Approval Date20 Jan 1800
100 Clinical Results associated with PTP4A2
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100 Translational Medicine associated with PTP4A2
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0 Patents (Medical) associated with PTP4A2
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162
Literatures (Medical) associated with PTP4A2
10 Apr 2025Biochemical Journal
The PRL2 phosphatase up-regulates miR-21 through activation of the JAK2/STAT3 pathway to down-regulate the PTEN tumor suppressor
01 Apr 2025Phytotherapy Research
Promising natural products targeting protein tyrosine phosphatase SHP2 for cancer therapy
28 Mar 2025Circulation Research
Stop Me at Your Own PeRiL: PRL2 Constrains AMPK in the Pressure-Overloaded Heart

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