NCT07773935 Cycloserine Stress Disorders, Post-Traumatic Clinical Landscape Report 2026: Design, Endpoints, Sponsor and Readout Outlook
Turn a newly registered trial into a decision-ready clinical landscape. This report examines NCT07773935 using PatSnap Clinical Trials MCP for protocol design and endpoint evidence, with Drug & Asset MCP and Company & Deal Intelligence MCP used as the companion asset and sponsor enrichment workflow. Explore PatSnap MCP Servers to reproduce the research sequence inside an AI workflow.
MCP evidence snapshot: 1 September 2026. Trial records, recruitment status and projected dates can change after the snapshot and should be rechecked before operational decisions.
Why NCT07773935 is a hot trial to watch
Stress Disorders, Post-Traumatic is being segmented by mechanism, treatment setting, geography and endpoint architecture. NCT07773935 is notable because it evaluates Cycloserine in a Phase 2 design sponsored by University of British Columbia. The main development question is whether the protocol can translate its rationale into a clinically interpretable and operationally credible readout.
Trial landscape snapshot
| Field | Indexed detail |
|---|---|
| Registration | NCT07773935 |
| Official title | ONE-P TMS First Responders (ONE-P_FR) |
| Phase / status | Phase 2 / Not yet recruiting |
| Intervention | Cycloserine |
| Sponsor | University of British Columbia |
| Geography | Canada |
| Enrollment | 50 |
| Primary endpoint | Feasibility of one-day iTBS+DCS: Enrolment |
| Endpoint time frame | 2 years |
| Primary completion / readout proxy | Not reported |
Protocol design and endpoint interpretation
The aim of this study is to examine the feasibility and tolerability of a one-day protocol of repetitive transcranial magnetic stimulation with D-cycloserine (DCS) as an augmentation strategy in first responders who have PTSD.
Allocation is Randomized, masking is Triple, and the intervention model is Parallel Assignment. Planned enrollment of 50 participants across Canada shapes statistical precision, execution risk and external validity. Interpretation should account for baseline risk, prior therapy, assessment schedule, missing-data handling and clinical relevance—not only statistical significance.
- Feasibility of one-day iTBS+DCS: Enrolment (2 years) — Enrollment rate: participants enrolled ÷ enrolment target by the end of 1.5 years will be ≥ 70% of the enrollment targe
- Feasibility: Adherence (2 years) — Proportion of randomized participants receiving ≥80% of scheduled iTBS sessions, defined as ≥24 session
- Feasibility: dropout rates (2 years) — Percentage of dropout rates attributable to the intervention will be ≤ 10%
Readout outlook and evidence gap
The current protocol points to Not reported as the best available readout proxy. Because this is an active or newly posted study, a trial-specific result citation is not included until a normalized clinical-trial-result record becomes available. That gap is itself operationally important: teams should monitor first result indexing, conference abstracts, protocol amendments and changes to the primary-completion date.
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Asset and sponsor context
Drug & Asset MCP profile: Cycloserine is indexed as No normalized modality returned, with target No normalized target returned, mechanism No normalized mechanism returned, and global highest development status No normalized global status returned.
Company & Deal Intelligence MCP profile: University of British Columbia is resolved to a normalized organization record in Canada. The organization workflow adds identity, location, portfolio and partnering context where available.
The sponsor profile matters because scientific rationale alone does not determine development value. Manufacturing readiness, portfolio fit, geographic reach, partnering capacity and the ability to fund confirmatory development can determine whether a positive signal becomes a competitive asset.
White space around this program
- Sharper patient selection: prospective biomarker or phenotype definitions that identify who is most likely to benefit.
- Clinically interpretable endpoints: outcomes connecting activity with function, symptoms, survival or treatment burden.
- Comparator relevance: evidence against the most decision-relevant contemporary standard of care.
- Broader external validity: evidence across additional geographies, demographic groups and real-world settings.
- Operational differentiation: a development path that closes the readout gap without sacrificing safety or durability.
What to monitor next
Monitor recruitment, enrollment changes, protocol amendments, endpoint hierarchy, primary-completion timing, first result indexing, asset ownership and sponsor partnerships. A change in endpoint, population or ownership can alter the probability of success before a headline data release.
Bottom line
NCT07773935 provides a focused lens on Stress Disorders, Post-Traumatic development. Its value will be determined by whether Cycloserine can convert the current Phase 2 design into evidence that is clinically meaningful, operationally credible and differentiated from competing programs.
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