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Last update 08 May 2025

Potassium Deficiency

Last update 08 May 2025

Basic Info

Synonyms

Deficiencies, Potassium, Deficiency, Potassium, K deficiency

+ [20]

Introduction

A condition due to decreased dietary intake of potassium, as in starvation or failure to administer in intravenous solutions, or to gastrointestinal loss in diarrhea, chronic laxative abuse, vomiting, gastric suction, or bowel diversion. Severe potassium deficiency may produce muscular weakness and lead to paralysis and respiratory failure. Muscular malfunction may result in hypoventilation, paralytic ileus, hypotension, muscle twitches, tetany, and rhabomyolysis. Nephropathy from potassium deficit impairs the concentrating mechanism, producing POLYURIA and decreased maximal urinary concentrating ability with secondary POLYDIPSIA. (Merck Manual, 16th ed)

Drugs associated with Potassium Deficiency

Potassium Chloride

Target-

Mechanism-

Active Org.

Upsher-Smith Laboratories LLC [+4]

Originator Org.

Eli Lilly & Co.

Active Indication

Potassium Deficiency [+2]

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

Japan

First Approval Date06 Mar 1970

Clinical Trials associated with Potassium Deficiency

NCT05975632

/ RecruitingNot Applicable

GAMMA Study: Patient Self-testing of Capillary Blood Potassium: A Validation Study and Measurement Performance in Patients.

Multicentre, open, prospective and interventional study investigating the CardioRenal device in capillary blood of patients.It will be conducted at multiple investigational sites.

Start Date02 Aug 2023

Sponsor / Collaborator

CardioRenal

NCT04907773

/ CompletedNot Applicable

Evaluation of a Blood Potassium Measurement Device From Capillary Samples

This is an open, prospective, and interventional study investigating the potassium measurement with the CardioRenal device in capillary blood. It will be conducted at one investigational site.
Each subject will have capillary blood collections. Additionally as a reference a venous blood collection will be conducted

Start Date01 Jul 2021

Sponsor / Collaborator

CardioRenal

NCT05385640

/ CompletedNot ApplicableIIT

Serum Potassium as a Predictor of Clinical Outcomes in an Older Patient Cohort With Chronic Postsurgical Pain: Retrospective Analysis of A Multi-Center Prospective Database in China

Perioperative serum potassium in patients over 65 impacts recovery, quality of life and physical functioning. While perioperative serum potassium is an important preoperative risk factor for poor surgical outcomes in older adults, the relationship between perioperative serum potassium and postsurgical pain in this population has not been investigated. The investigators hypothesized that preoperative serum potassium would be associated with greater odds of postsurgical chronic pain.

Start Date01 Apr 2020

Sponsor / Collaborator

Chinese People's Liberation Army General Hospital

[+6]

100 Clinical Results associated with Potassium Deficiency

100 Translational Medicine associated with Potassium Deficiency

0 Patents (Medical) associated with Potassium Deficiency

1,082

Literatures (Medical) associated with Potassium Deficiency

01 Jun 2025·Plant Science

MdNAC2 enhances K+ deficiency stress tolerance by maintaining K+ homeostasis in apple

Article

Author: Lyu, Yi ; Cui, Yaqi ; Li, Jianyu ; Zheng, Xiaodong ; Zhao, Qiang ; Ma, Changqing ; Sun, Zhijuan ; Wang, Caihong ; Tian, Yike ; Wang, Tianchao

Potassium (K) is an essential nutrient for apple production, with its deficiency severely compromising yield and fruit quality. The development of K deficiency-resistant rootstocks represents an effective and promising approach to alleviating the adverse effects of K deficiency stress. However, the molecular mechanisms underlying apple resistance to K deficiency remain poorly understood. Here, we identified the transcription factor MdNAC2 as a critical regulator of apple tolerance to K deficiency through RNA-seq using Malus hupehensis as material. MdNAC2 enhanced apple tolerance to K deficiency by maintaining K⁺ homeostasis, primarily through directly suppressing the expression of the K⁺ efflux transporter MdGORK1. This regulatory mechanism reduces K⁺ efflux and stabilizes intracellular K⁺ levels under K deficiency stress. Collectively, our findings highlight the pivotal role of the MdNAC2-MdGORK1-K⁺ regulatory module in maintaining K⁺ and conferring apple resistance to K deficiency. This study provides new insights into the molecular mechanisms of K deficiency tolerance and establishes a theoretical foundation for breeding K deficiency-resistant apple rootstocks and cultivars.

04 Feb 2025·Analytical Chemistry

Dynamic Light Scattering Analysis of Lipid Nanoparticles: Effect of Salts on the Diffusion Interaction Parameter and Hydrodynamic Radius at Infinite Dilution

Article

Author: Curtis, Robin ; Falconer, Robert John ; Francis, Jaslene Anne ; Wright, Leah

The rise in the popularity of lipid nanoparticle (LNP)-based formulations necessitates the need for screening tools to quickly predict their colloidal stability in the presence of common excipients. Protein chemists have employed the diffusion interaction parameter (k_D) determined using dynamic light scattering as an indicator of formulation stability, yet this approach has not been applied to particulate systems. Herein, k_D measurements of LNPs revealed behavior dissimilar to that of proteins. LNP interactions were inherently weakly attractive and unaffected by increasing concentrations of NaCl. The small change in the value in the presence of different salts was dependent upon salt molecular identity and consistent with the Hofmeister series. In addition, calculation of the hydrodynamic radius at infinite dilution (R_H,0) revealed a slight reduction in the LNP size with increasing NaCl concentration. Overall, while traditional k_D measurements provide limited information about LNP stability, the assay provides insight into physical changes to LNP in the presence of excipients via extrapolation of the diffusion coefficient to infinite dilution.

01 Dec 2024·Data in Brief

Dataset of infected date palm leaves for palm tree disease detection and classification

Article

Author: Alkhodre, Ahmad B ; Namoun, Abdallah ; Almoamari, Hani ; Sen, Adnan Ahmad Abi ; Alkhodre, Ahmad B. ; Alsaawy, Yazed

This article presents an image dataset of palm leaf diseases to aid the early identification and classification of date palm infections. The dataset contains images of 8 main types of disorders affecting date palm leaves, three of which are physiological, four are fungal, and one is caused by pests. Specifically, the collected samples exhibit symptoms and signs of potassium deficiency, manganese deficiency, magnesium deficiency, black scorch, leaf spots, fusarium wilt, rachis blight, and parlatoria blanchardi. Moreover, the dataset includes a baseline of healthy palm leaves. In total, 608 raw images were captured over a period of three months, coinciding with the autumn and spring seasons, from 10 real date farms in the Madinah region of Saudi Arabia. The images were captured using smartphones and an SLR camera, focusing mainly on inflected leaves and leaflets. Date palm fruits, trunks, and roots are beyond the focus of this dataset. The infected leaf images were filtered, cropped, augmented, and categorized into their disease classes. The resulting processed dataset comprises 3089 images. Our proposed dataset can be used to train classification deep learning models of infected date palm leaves, thus enabling the early prevention of palm tree-related diseases.

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Potassium Deficiency

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