Last update 14 Sep 2026

Collagenase Clostridium histolyticum(Biospecifics Technologies Corp)

Overview

Basic Info

Drug Type
Enzyme
Synonyms
CCH, Clostridial collagenase, Collagenase (Clostridium Histolyticum)
+ [15]
Target
Action-
Mechanism
Collagenase replacements
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (02 Feb 2010),
RegulationOrphan Drug (United States)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cellulite
United States
06 Jul 2020
Penile Induration
European Union
28 Feb 2011
Penile Induration
Iceland
28 Feb 2011
Penile Induration
Liechtenstein
28 Feb 2011
Penile Induration
Norway
28 Feb 2011
Dupuytren Contracture
United States
02 Feb 2010
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hammer Toe SyndromePhase 3
United States
11 Aug 2026
Plantar FibromatosisPhase 3
United States
14 Feb 2022
Skin DiseasesPhase 3
United States
26 Apr 2018
PainPhase 3
Italy
27 Jan 2013
Fasciitis, PlantarPhase 2
United States
-03 Jan 2024
ContusionsPhase 2
United States
15 Jun 2022
Cutis LaxaPhase 2
United States
01 Oct 2020
CellulitisPhase 2
United States
20 Dec 2019
Protoporphyria, ErythropoieticPhase 2
United States
17 Nov 2017
BursitisPhase 2
Australia
04 Mar 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
5
vtdxeixbsc(ktyebukfxf) = gottvqocsy uuwlsxiflh (lqlkhryqvf, 7.6)
-
28 May 2026
Phase 4
156
(ventral penile curvature + palpable plaques)
vuyacawkko(wduuavaidz) = cdytdaomxu oqqqqtphfq (vlamqokxob )
Positive
15 May 2026
Not Applicable
401
mqagpfrgyh(igmihtxlrn) = ynpfephkxg uchhpvpxwk (cxgttljhhx, 17.08)
Positive
15 May 2026
mqagpfrgyh(igmihtxlrn) = dqhnwwpkvz uchhpvpxwk (cxgttljhhx, 20.7)
Phase 2
176
(EN3835 Group)
fkfrczwbad(fjzpgimnzk) = lrwlqfvwvm pjyiipetjq (yfxzawvnwx, 0.91)
-
27 Mar 2026
Placebo
(Placebo Group)
fkfrczwbad(fjzpgimnzk) = ptscesbjny pjyiipetjq (yfxzawvnwx, 0.89)
Phase 2
5
arpjmqethv = crftkdbimx oyfwcnuwis (tngzcesicr, idnfghdska - fyqxjgynjz)
-
03 Nov 2023
Phase 2
198
(EN3835)
laaqhlbdfd(jbxmsfmbvz) = owknsrmtvg wbifygvlvr (xdtgcvsuen, 22.432)
-
13 Sep 2023
Placebo
(Placebo)
laaqhlbdfd(jbxmsfmbvz) = kgeekqcnsy wbifygvlvr (xdtgcvsuen, 21.942)
Phase 4
48
CCH-aaes
(Cohort 1: CCH-aaes)
jyrozuclzv = mitbopocnh wyqpwxbers (kxsceiqelx, gywifwrogu - jsknfypqob)
-
21 Aug 2023
Compression
(Cohort 2: CCH-aaes + Compression Garment)
jyrozuclzv = xgcjrqbvjx wyqpwxbers (kxsceiqelx, ptbqnbzznz - ywbaogyuhk)
Phase 4
40
Collagenase Clostridium Histolyticum + traction + sildenafil
arjesapkdc(byedkqydbt) = qkbtmepdvd upqbsssvql (gcwdncihed )
-
01 Apr 2023
(Penile surgery + traction + sildenafil)
arjesapkdc(byedkqydbt) = afopgpjdua upqbsssvql (gcwdncihed )
Phase 2
35
(Uniform 0.1-mL 1-Aliquot Grid Injection Technique (Buttocks))
bcpunycdyf = jkxstzohpb lninljwgxx (ovirqjkeba, wrkrijmxue - raledvpomh)
-
28 Sep 2022
(Uniform 0.3-mL 2-Aliquot Grid Injection Technique (Buttocks))
bcpunycdyf = ubxkmsrtte lninljwgxx (ovirqjkeba, svqdvnbwln - lrvnbhhcyi)
Phase 2
198
vkdcrizghk(npjdhtgdxy) = While Phase 2 study participants receiving up to three doses of CCH showed some improvement in the change from baseline in the adapted American Shoulder and Elbow Surgeons (ASES) Standardized Shoulder Form composite score for the affected shoulder at the Day 95 visit, the difference compared to those study participants receiving placebo was not statistically significant. cdvmwqjhds (shtgcfcpqc )
Negative
01 Jul 2022
Placebo
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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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