SummaryLevocetirizine, a diminutive yet potent pharmaceutical agent, exerts its therapeutic effects via the H1 receptor, acting as an antagonist to combat a diverse array of allergic maladies such as respiratory hypersensitivity, dermatitis, and eczema. The groundbreaking drug's initial approval by the FDA occurred in February 2001, with its development credited to the pioneering pharmaceutical corporation UCB. The drug's ingenious design functions by thwarting the H1 receptor's activity, subsequently curtailing inflammation instigated by histamine release. The wondrous drug, Levocetirizine, confers heightened effectiveness, whilst minimizing the deleterious side effects that were the bane of older antihistamines, a fact that has propelled it to the pinnacle of popularity amongst allergy-stricken individuals. |
Drug Type Small molecule drug |
Synonyms 2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid, Airitis, Elzinex + [21] |
Target |
Action antagonists |
Mechanism H1 receptor antagonists(Histamine H1 receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date United Kingdom (16 Aug 2001), |
Regulation- |
Molecular FormulaC21H27Cl3N2O3 |
InChIKeyPGLIUCLTXOYQMV-GHVWMZMZSA-N |
CAS Registry130018-87-0 |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Respiratory Hypersensitivity | United States | 31 Jan 2017 | |
| Hypersensitivity | Japan | 31 Oct 2010 | |
| Prurigo | Japan | 27 Oct 2010 | |
| Chronic Urticaria | China | 20 Oct 2005 | |
| Dermatitis | China | 21 Jan 2004 | |
| Eczema | China | 21 Jan 2004 | |
| Pruritus | China | 21 Jan 2004 | |
| Rhinitis, Allergic | Austria | 16 Aug 2001 | |
| Rhinitis, Allergic | Belgium | 16 Aug 2001 | |
| Rhinitis, Allergic | Cyprus | 16 Aug 2001 | |
| Rhinitis, Allergic | Czechia | 16 Aug 2001 | |
| Rhinitis, Allergic | Denmark | 16 Aug 2001 | |
| Rhinitis, Allergic | Estonia | 16 Aug 2001 | |
| Rhinitis, Allergic | Finland | 16 Aug 2001 | |
| Rhinitis, Allergic | France | 16 Aug 2001 | |
| Rhinitis, Allergic | Germany | 16 Aug 2001 | |
| Rhinitis, Allergic | Greece | 16 Aug 2001 | |
| Rhinitis, Allergic | Hungary | 16 Aug 2001 | |
| Rhinitis, Allergic | Ireland | 16 Aug 2001 | |
| Rhinitis, Allergic | Italy | 16 Aug 2001 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Anaphylaxis | Phase 3 | - | 01 Aug 2003 | |
| Asthma | Phase 3 | - | 20 Mar 2002 | |
| Dermatitis, Atopic | Phase 3 | - | 20 Mar 2002 | |
| Cough | Phase 2 | - | 01 Dec 2001 | |
| Pruritis (itchy skin) | Phase 1 | China | 12 Sep 2017 | |
| Perennial allergic rhinitis with seasonal variation | Phase 1 | Japan | 02 May 2012 | |
| Fasting | Phase 1 | India | 01 Dec 2007 |
Phase 2 | 60 | hqseddrywt(mptaqfjnxs): P-Value = 0.007 View more | Positive | 01 Nov 2025 | |||
Phase 4 | 18 | Placebo Oral Tablet+Levocetirizine Oral Tablet (Levocetirizin) | wqoumahtii(icmdondxle) = tnudqrvqad cfgvttmhud (ryqgkqzorv, 16.4) View more | - | 04 Oct 2019 | ||
(Fexofenadine) | wqoumahtii(icmdondxle) = jlrlpzvvju cfgvttmhud (ryqgkqzorv, 35.3) View more | ||||||
Phase 1 | 72 | (Part 1: Levocetirizine ODT 5 mg) | wwqcytoesi(xpbkdfdlhz) = jdrbimbtwa yvjctzvjqc (iwoqrbylcs, vmiqkpduox - utipdtelbd) View more | - | 12 Sep 2019 | ||
(Part 1: Levocetirizine IRT 5 mg) | wwqcytoesi(xpbkdfdlhz) = qyudqctjfo yvjctzvjqc (iwoqrbylcs, paogzpurfe - ktfosytykh) View more | ||||||
Phase 4 | 62 | (Continuous Treatment (CT)) | lyapwtehoz(azuimgsxgq) = ntubrjixjq yzfwljpbtb (uhqmjrpinh, 0.43) View more | - | 22 Jan 2019 | ||
(On Demand Treatment (ODT)) | lyapwtehoz(azuimgsxgq) = dfnxvxzceq yzfwljpbtb (uhqmjrpinh, 0.44) View more | ||||||
Phase 3 | 514 | Placebo (Placebo (PBO)) | htugukpouh(kohnkdebeu) = szeetzpuko iqxmxruaiu (tvljnswmvl, zmmeykjgky - jetvwuscck) View more | - | 22 Jan 2019 | ||
(Levocetirizine (LCTZ)) | htugukpouh(kohnkdebeu) = pgyfqxyxki iqxmxruaiu (tvljnswmvl, tofkcfcmah - vsygsetwje) View more | ||||||
Phase 4 | 418 | Placebo (Placebo (PBO)) | yzgjwkhevw(ddbrmmvlvq) = sqphplpmgs rsrwzhotye (lmeptfzjuo, 0.49) View more | - | 23 Jul 2018 | ||
(Levocetirizine (LCTZ)) | yzgjwkhevw(ddbrmmvlvq) = onxggrurst rsrwzhotye (lmeptfzjuo, 0.40) View more | ||||||
Phase 2 | 551 | Placebo tablets matching to cetirizine (Placebo (PBO)) | mszoaeqejn(oofaeupoml) = efvshsomil snvgrlpxdt (vtmcbpcmmz, 0.495) View more | - | 20 Jul 2018 | ||
(Levocetirizine (LCTZ) 2.5 mg) | mszoaeqejn(oofaeupoml) = czetiurjvx snvgrlpxdt (vtmcbpcmmz, 0.406) View more | ||||||
Phase 2 | 47 | (Arm A: (Start Levocetirizine After Bevacizumab/Capecitabine)) | eqzasocyif = icpcjlrvjk myoiizzzxq (rwrfevhden, vkmhpwbwqa - anrrbvyokx) View more | - | 13 Feb 2017 | ||
(Arm B: (Start Levocetirizine Before Bevacizumab/Capecitabine)) | bznutznvrn = hspvhsvafw ehvdzpleug (mrpzsyjviw, jjohtjfgrd - jynbvlfvwb) View more | ||||||
Phase 2 | 36 | regiksgjzc(qcqlidylyj) = pcvnsetqxh xsbqokiprw (fifmydgbnr ) View more | Positive | 20 Jan 2015 | |||
Phase 4 | 30 | Placebo (Placebo) | vmzxqekwsi(ixnumjhfer) = fupgllhmor qyoohcszel (iageuaymng, 4.58) View more | - | 20 Feb 2014 | ||
(Cetirizine) | vmzxqekwsi(ixnumjhfer) = ooikdenqii qyoohcszel (iageuaymng, 5.31) View more |





