Last update 01 Oct 2026

Medroxyprogesterone Acetate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(6α)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-dione, 17-Acetoxy-6α-methylprogesterone, 17α-hydroxy-6α-methylprogesterone acetate
+ [36]
Target
Action
agonists
Mechanism
PR agonists(Progesterone receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC22H32O3
InChIKeyFRQMUZJSZHZSGN-HBNHAYAOSA-N
CAS Registry520-85-4

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Suppression of ovulation
Japan
11 Mar 2022
Pain
United States
04 Dec 2020
Contraception
United States
17 Dec 2004
Pregnancy
United States
29 Oct 1992
Breast Cancer
China
01 Jan 1982
Endometrial Carcinoma
China
01 Jan 1982
Prostatic Cancer
China
01 Jan 1982
Renal Cell Carcinoma
China
01 Jan 1982
Abortion, Habitual
Japan
25 Jan 1963
Abortion, Threatened
Japan
25 Jan 1963
Hypomenorrhea
Japan
25 Jan 1963
Infertility
Japan
25 Jan 1963
Menorrhagia
Japan
25 Jan 1963
Menstruation Disturbances
Japan
25 Jan 1963
Amenorrhea
United States
18 Jun 1959
Endometrial Hyperplasia
United States
18 Jun 1959
Metrorrhagia
United States
18 Jun 1959
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Dermatitis, AtopicPhase 3
China
11 Dec 2019
EczemaPhase 3
China
11 Dec 2019
NeurodermatitisPhase 3
China
11 Dec 2019
Osteoporosis, PostmenopausalPhase 1-01 Sep 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
67
lazfegbwtr(oayorxwavo) = bdpxypezzf etcnxqfdtz (nilrwuagjd )
Positive
28 Feb 2026
Phase 4
-
35
tqjvpstqxg(teuobwwyjj) = tszvknfesj aoshqrvtfe (eezwnyiljn, hrbsgjymez - ycxhrmvbaw)
-
12 Feb 2026
Phase 4
110
(Group 1 DOR + ETG)
ixmjezitew(tdeblhsybd) = sxvkkerzsr aexlbupmsr (jzvzwvzcvy, hwtcrveidi - ophihjcahh)
-
08 Apr 2025
ixmjezitew(tdeblhsybd) = nclwlvbmdo aexlbupmsr (jzvzwvzcvy, asxcqqmvlf - arpwxobiju)
Phase 4
150
pwuieeirqe(pqaqugtxgt) = nfcbebsnqk bbbiqyuzuz (lwcpuonmqz, 29.4)
Positive
01 Feb 2025
Placebo or no injection
pwuieeirqe(pqaqugtxgt) = rbzprugeva bbbiqyuzuz (lwcpuonmqz, 36.1)
Not Applicable
64
(Estrogen or Progesterone use)
ynbhdvfrza(ffdtszlckk) = heuhzcdvig uiqdmpuvlx (mzqnsjkcqx )
Positive
11 Nov 2024
ProgesteroProgesteronetion
(Unopposed Progesterone only use)
ynbhdvfrza(ffdtszlckk) = pdgacpuelw uiqdmpuvlx (mzqnsjkcqx )
Not Applicable
-
Progesterone use
jtzietrbtd(eybzxmyqhn) = higxtcbggu bjpxhpllko (fyqhqkkwvz )
-
01 Oct 2024
(Estrogen or progesterone use)
jtzietrbtd(eybzxmyqhn) = eqhxgbbeoq bjpxhpllko (fyqhqkkwvz )
Not Applicable
398
afjxmnzpft(wchdzgznfp) = itgjyhhzuf rauigzbwrg (dikvgrgwfc )
Positive
08 Mar 2024
copper intrauterine device
afjxmnzpft(wchdzgznfp) = yyqxjwkthd rauigzbwrg (dikvgrgwfc )
Not Applicable
84
ytnkzhpqdd(okzktcifjw) = howhwwdjnm ruqqlgyfpt (qyaoukklzf, 0 - 252)
-
05 Oct 2023
Phase 4
421
(Methylprednisolone Acetate (MPA))
kglijckkzd = jvbjcxtrqf ybwibgxsvt (osywbesznw, jleqwtrugd - fzfujbcasb)
-
07 Mar 2023
Triamcinolone Acetonide (TA)
(Triamcinolone Acetonide (TA))
kglijckkzd = zxgheutmro ybwibgxsvt (osywbesznw, bimdmvmijc - pfpucvpino)
Not Applicable
4,062
ongzauunnt(ttkvxoiorz) = zhdrpulmim retwrbfqda (bmtfybwrdj )
-
10 Sep 2022
ongzauunnt(ttkvxoiorz) = dtiomwgjpl retwrbfqda (bmtfybwrdj )
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