Delving into the Latest Updates on Paclitaxel Poliglumex with Synapse

Overview

Basic Info

Drug Type

Polymer

Synonyms

Opaxio, Paclitaxel poliglumex (USAN/INN), PG-TXL

+ [9]

Target

Tubulin

Action

inhibitors

Mechanism

Tubulin inhibitors

Therapeutic Areas

NeoplasmsRespiratory DiseasesNervous System Diseases+ [7]

Active Indication-

Inactive Indication

Advanced Colorectal AdenocarcinomaAdvanced Lung Non-Small Cell CarcinomaAstrocytoma+ [14]

Originator Organization

CTI BioPharma Corp.

Active Organization-

Inactive Organization

CTI BioPharma Corp.

Brown University

License Organization-

Drug Highest PhaseDiscontinuedPhase 3

First Approval Date-

RegulationOrphan Drug (United States)

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Structure/Sequence

Molecular FormulaC52H60N2O18

InChIKeyZPUHVPYXSITYDI-HEUWMMRCSA-N

CAS Registry263351-82-2

The investigators propose to conduct a clinical trial of neoadjuvant treatment utilizing chemotherapy formulations with favorable toxicity profiles: weekly doxorubicin, PPX and capecitabine. It is expected this combination will at least maintain the efficacy of a traditional chemotherapy regimen but will be associated with less toxicity, particularly nausea, vomiting and alopecia. In order to accomplish this the investigators have designed a chemotherapy regimen whose components (or administration schedule) are associated with minimal or no alopecia and are also considered to have low emetogenic potential.
In an attempt to improve the efficacy of the regimen the investigators plan to study an alternate schedule of cyclophosphamide and methotrexate administration (metronomic chemotherapy) which appears to inhibit angiogenesis and therefore enhance the activity of conventional cytotoxic chemotherapy administered concurrently.
In this trial the investigators aim to determine the clinical and pathologic response rate of 12 weeks of doxorubicin followed by 4 cycles of PPX and capecitabine. Metronomic chemotherapy with cyclophosphamide and methotrexate will be administered during the 24 weeks of chemotherapy.

Start Date01 Feb 2009

Sponsor / Collaborator

University of Southern California

[+1]

NCT00763750

/ CompletedPhase 2IIT

BrUOG-Brain-223-A Phase II Study of PPX (CT-2103), Temozolomide, and Concurrent Radiation for Newly Diagnosed Brain Tumors (CTI # CT2103) Principal Investigator: Howard Safran, M.D.

The purpose of this study is to determine the antitumor activity of PPX in combination with temozolomide and radiation for patients with newly diagnosed brain tumors.

Start Date01 Oct 2008

Sponsor / Collaborator

Brown University

[+2]

100 Clinical Results associated with Paclitaxel Poliglumex

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100 Translational Medicine associated with Paclitaxel Poliglumex

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100 Patents (Medical) associated with Paclitaxel Poliglumex

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280

Literatures (Medical) associated with Paclitaxel Poliglumex

01 Dec 2025·COLLOIDS AND SURFACES B-BIOINTERFACES

Polyglutamic acid and Pluronic F127-based hydrogel for loading sinomenine hydrochloride liposomes in the treatment of rheumatoid arthritis

Article

Author: Chen, Dawei ; Han, Yanyan ; Guo, Zongjin ; Hu, Haiyang ; Zhao, Ming ; Peng, Chang ; Peng, Jiayi

Sinomenine hydrochloride (SNH), a key therapeutic agent for rheumatoid arthritis (RA), is limited by its low bioavailability, rapid metabolism, and frequent dosing requirements. This study innovatively developed a composite delivery system (SNH-Lip@PPGels) based on polyglutamic acid-poloxamer F127 thermosensitive hydrogel-encapsulated liposomes. In vitro drug release conformed to the Korsmeyer-Peppas kinetic model, demonstrating sustained-release characteristics. In vivo studies confirmed that SNH-Lip@PPGels precisely targets the joint cavity, with intra-articular retention exceeding 24 h. The system alleviates joint swelling and tissue damage in RA models by inhibiting M1 macrophage polarization, significantly reducing TNF-α and IL-6 levels while elevating anti-inflammatory IL-10. Notably, the SNH-Lip@PPGels group exhibited no systemic toxicity, with body weight profiles and histopathology tissues comparable to the normal group. This work proposes a novel RA therapeutic strategy integrating localized targeting and biosafety.

01 Nov 2025·JOURNAL OF ENVIRONMENTAL MANAGEMENT

Characteristics of microbial phosphorus cycling in Phyllostachys praecox forest soils supplemented with the phosphate-solubilizing bacterium Pseudomonas sp. OP1 revealed by metagenomics

Article

Author: Wu, Zhizhuang ; Huang, Zhiyuan ; Zhong, Zheke ; Peng, Yuwen ; Bian, Fangyuan ; Zhang, Xiaoping

Soil phosphorus (P) is an essential nutrient for plants and a limiting factor in bamboo forest productivity. Plant endophytic phosphate-solubilizing bacteria (PSB) play a crucial role in soil P cycling. However, the mechanisms by which they influence soil P cycling in bamboo forests remain unclear. Here, we employed a metagenomics approach to evaluate the effects of the endophytic PSB Pseudomonas sp. OP1 on microbial P cycling in Phyllostachys. praecox forest soils. OP1 treatment significantly increased labile phosphorus (LP), moderately labile phosphorus (MLP), and nonlabile phosphorus (NLP) by 23.7, 40.37, and 18.98 % compared with the control (CK), respectively (p < 0.05). OP1 further significantly increased the abundance of functional genes associated with inorganic P solubilization and P transport. OP1-treated soils were enriched in ppx, gcd, ugpC, phnW, and phoN, whereas CK was characterized by phnC, phnP, ppa, and phnO. OP1 application altered the community structure of P-cycling microorganisms, enriching Chloroflexi and Bradyrhizobium while reducing Firmicutes and Streptomyces. Mantel tests revealed significant relation of soil P fractions to alkali-hydrolyzed nitrogen (AN), P-cycling genes, and the related microbial communities. Specifically, AN, ppx, phnW, phoN, and Nitrospirae (complete ammonia oxidizers) were significantly positively correlated with LP, MLP, and NLP, while Planctomycetota (anaerobic ammonia oxidizers) exhibited negative correlations with these P fractions, highlighting nitrogen-P co-regulation and microbial-mediated P transformation. These findings highlight the potential of PSB in enhancing soil P-use efficiency and reducing chemical phosphate fertilizer use, providing insights into the microbial mechanisms underlying P cycling in bamboo forests and supporting sustainable bamboo plantation management.

01 Sep 2025·JOURNAL OF APPLIED TOXICOLOGY

Pyriproxyfen Disrupts the Ongoing Spermatogenesis Wave in Danio rerio Potentially Mediated by Voltage‐Dependent Calcium Channels and Protein Kinase C

Article

Author: Grinevicius, Valdelúcia Maria Alves de Souza ; Leite, Gabriel Adan Araujo ; Zaniboni, Bruna Antunes ; Silva, Fátima Regina Mena Barreto ; Pedrosa, Rozangela Curi ; Oliveira, Vanessa Staldoni de

ABSTRACT:

Pyriproxyfen (PPX) is an analog of the juvenile hormone from insects. Following our previous studies, for the ex vivo short‐term effect, we chose 10−9 M pyriproxyfen to analyze the morphology of spermatogenesis wave cells. In silico docking and ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) studies were carried out to preliminarily predict possible interaction modes between PPX and the T‐type voltage‐dependent calcium channel (T‐VDCC), as well as with protein kinase C (PKC), as we previously reported by using pharmacological approach. The in silico ADMET evaluations revealed that PPX demonstrates notable lipophilicity. Moreover, PPX is predicted to inhibit the enzymatic activity of CYP1A2, CYP2C19, CYP2C9, and CYP2D6. Furthermore, in silico molecular docking analyses revealed that PPX has the potential to interact with the T‐VDCC through hydrogen bonds with Gln1653 and hydrophobic interactions with Leu291, Phe322, Phe1607, and Leu1656. Possible interactions of PPX with PKC involve ionic bonding with Lys463, hydrogen bonds with His592, and hydrophobic interactions with Lys463, Val596, Gly591, Phe593, Lys611, Asp711, and Leu714 reinforcing these both targets to PPX. In summary, short‐term PPX exposure influenced the morphology of testicular cells (spermatids, spermatozoa, and Leydig cells) through interactions with molecular targets. Findings reveal the bimodal effects (on morphology and signaling) of this compound on specific cells within the spermatogenic wave, endocrine cells, and signal transduction proteins. This interference may impair reproduction and lead to male infertility. In addition, the prediction from both molecular docking and ADMET supported our in vitro mechanistic analysis firstly reported in the testis of Danio rerio.

2

News (Medical) associated with Paclitaxel Poliglumex

27 Jul 2023

·www.sciencedaily.com

Self-healing plastic becomes biodegradable

Chemists develop mineral plastics with numerous positive properties from sustainable basic building blocks and, together with biologists, demonstrate the material's excellent microbiological degradability. Imagine a plastic like this: harder than common plastics, non-flammable, and even with self-healing properties. But that is not all! It can be produced at room temperature in water, which is very energy-efficient and does not require toxic solvents. Before hardening, you can shape the plastic in any way you want -- like chewing gum. By adding water, it can also be converted back to its "chewing gum" form at any time, reshaped and thus recycled as often as desired. Is that impossible? No, it is not! In 2016, the research team around Konstanz chemist Helmut Cölfen presented just such a material -- a mineral plastic. However, even though the plastic, with its novel manufacturing process and outstanding material properties, has since attracted great interest from industry, it still had a crucial shortcoming from the Konstanz chemists' point of view: due to its chemical composition, it was difficult to biodegrade. A new ingredient for greater environmental compatibility "Previously, we used polyacrylic acid to produce our mineral plastic. Chemically, this acid has the same backbone as polyethylene, which is known to cause major problems in the environment because it is hardly biodegradable," explains Cölfen. The research team led by Cölfen and Ilesha Avasthi, a postdoc in Cölfen's lab, therefore set to work looking for an alternative basic building block to develop an environmentally compatible mineral plastic that retains the intriguing properties of the original material. And they found what they were looking for. In their current publication in the journal Small Methods, the Konstanz chemists present the next generation of their mineral plastic. Instead of petroleum-based ingredients such as polyacrylic acid, they now use polyglutamic acid. This natural biopolymer is readily available in large quantities and can even be obtained sustainably, for example from biotechnological production using microorganisms. A variety of microorganisms that already exist in the environment can degrade polyglutamic acid. "Our new mineral plastic has the same positive properties as the previous one, but has the decisive advantage that its basic building block -- polyglutamic acid -- can be produced with the help of microorganisms and is completely biodegradable," says Helmut Cölfen. Support from biologists In order to prove that this biodegradability also applies to the new mineral plastic itself and not just to its individual components, the chemists enlisted the support of David Schleheck and postdoc Harry Lerner from the Department of Biology at the University of Konstanz. "Helmut Cölfen has created a new type of mineral plastic in his laboratory, and our task now was to make it disappear again with the help of microorganisms," says Schleheck with a smile. In degradation experiments, the biologists were able to show that microorganisms found in forest soils, for example, began metabolizing the mineral plastic after just a few days. After only 32 days, the microorganisms had completely degraded the plastic. So the researchers have actually succeeded in making the mineral plastic with all its positive material properties now also sustainable and biodegradable.

26 Jul 2022

·www.biospace.com

Organicell Announces Matt Sinnreich as CEO

MIAMI, FL / ACCESSWIRE / July 26, 2022 / Organicell Regenerative Medicine, Inc. (OTCQB:OCEL), a clinical-stage biopharmaceutical company principally focusing on the development of innovative biological therapeutics in the extracellular vesicle space, announced today that the board of directors has appointed Matt Sinnreich as Chief Operating Officer and acting CEO. Sinnreich will replace Mr. Albert Mitrani, the founder of Organicell and CEO since September 2019, who is stepping down to serve as the Company's EVP of sales. Sinnreich, an early-stage investor in Organicell, helped fund the company's audit in 2020 to bring their financials current and was instrumental in the creation of their flagship brand: Zofin. Sinnreich comes from a development and entrepreneurial background. His track record includes profitable corporate exits, successful real estate transactions, and owner-operated residential and commercial real estate developments. Sinnreich has closed tens of millions in various financing instruments including everything from traditional real estate debt, fundraising for private companies, to collateralized derivatives and swaps. Sinnreich is an early-stage investor in the ready to drink tequila-seltzer, Mamitas and owns a minority interest in Craig's Vegan Ice Cream. Sinnreich graduated from the University of Miami Business School in 2008 where he also won the 2008 Rothschild Business Plan Competition. In response to his appointment, Sinnreich stated: "I am humbled and grateful that the board and new investment groups have entrusted me to take Organicell to the next level. I believe that exosomes are a key element in the future of medicine and this company has the team to make that a reality. Albert and Mari Mitrani are pioneers in this space. They have assembled an incredible science team, developed an amazing product line, and built top tier production labs. All the ingredients are here for this company to become a major success. As COO and acting CEO I will be focused on creating additional financing vehicles, growing the awareness of our products and brand, and most importantly maintaining an honest, transparent relationship with the shareholders. My priorities right now are to work with our CFO, Ian Bothwell, to build out Organicell's core executive team. I will pull from my network to surround myself with the best and brightest in the medical and financial arenas. I plan to create a robust ERP and data management system and to set up additional financing vehicles to fund our clinical trials. I will also be taking to market Organicell's newest biological product: Patient Pure X™ (PPX™). PPX™ is Organicell's first autologous product that is a non-manipulated biologic that concentrates a patient's exosomes from their own peripheral blood. In plain English: we can concentrate a patient's exosomes from their own blood. Organicell's science team and researchers are currently conducting studies to prove PPX's effectiveness on pain, hair loss, its potential for aesthetic uses, and surgical recovery. Organicell's products have shown promising results in the early-stage data that has been collected. Once the company has the adequate data from our clinical trials to make the claims we are studying - I believe this company will be a disrupter in the biotech industry." About Organicell Regenerative Medicines, Inc. Organicell Regenerative Medicine, Inc. (OTCQB:OCEL) is a clinical-stage biopharmaceutical company principally focusing on the development of innovative biological therapeutics for the treatment of degenerative diseases and the provision of other related services. The Company's proprietary products are derived from perinatal sources and manufactured to retain the naturally occurring exosomes, hyaluronic acid, and proteins without the addition or combination of any other substance or diluent. To learn more, please visit Forward-Looking Statements Certain of the statements contained in this press release should be considered forward-looking statements within the meaning of the Securities Act of 1933, as amended (the "Securities Act"), the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and the Private Securities Litigation Reform Act of 1995. These forward-looking statements are often identified by the use of forward-looking terminology such as "will", "believes", "expects", "potential", or similar expressions, involving known and unknown risks and uncertainties. Although the Company believes that the expectations reflected in these forward-looking statements are reasonable, they do involve assumptions, risks and uncertainties, and these expectations may prove to be incorrect. We remind you that actual results could vary dramatically as a result of known and unknown risks and uncertainties, including but not limited to: potential issues related to our financial condition, competition, the ability to retain key personnel, product safety, efficacy and acceptance, the commercial success of any new products or technologies, success of clinical programs, ability to retain key customers, our inability to expand sales and distribution channels, legislation or regulations affecting our operations including product pricing, reimbursement or access, the ability to protect our patents and other intellectual property both domestically and internationally, and other known and unknown risks and uncertainties, including the risk factors discussed in the Company's periodic reports that are filed with the SEC and available on the SEC's website ( ). You are cautioned not to place undue reliance on these forward-looking statements. All forward-looking statements attributable to the Company or persons acting on its behalf are expressly qualified in their entirety by these risk factors. Specific information included in this press release may change over time and may or may not be accurate after the date of the release. Organicell has no intention and specifically disclaims any duty to update the information in this press release. Media Contact: Joshua Rodriguez CEO and Founder CNA Finance, LLC. (503) 464-6502 SOURCE: Organicell Regenerative Medicine, Inc. View source version on accesswire.com:

100 Deals associated with Paclitaxel Poliglumex

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External Link

KEGG	Wiki	ATC	Drug Bank
D05333	Paclitaxel Poliglumex	L01CD03	DB13809

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Advanced Lung Non-Small Cell Carcinoma	Phase 3	United States	CTI BioPharma Corp.	01 Jan 2003
Advanced Lung Non-Small Cell Carcinoma	Phase 3	Canada	CTI BioPharma Corp.	01 Jan 2003
progressive non-small cell lung cancer	Phase 3	United States	CTI BioPharma Corp.	01 Jan 2003
Recurrent Non-Small Cell Lung Cancer	Phase 3	United States	CTI BioPharma Corp.	01 Jan 2003
Recurrent Non-Small Cell Lung Cancer	Phase 3	Canada	CTI BioPharma Corp.	01 Jan 2003
HER2-negative breast cancer	Phase 2	United States	CTI BioPharma Corp.	01 Feb 2009
Astrocytoma	Phase 2	United States	Brown University	01 Oct 2008
Glioblastoma	Phase 2	United States	Brown University	01 Oct 2008
Glioblastoma Multiforme	Phase 2	United States	Brown University	01 Oct 2008
Oligodendroglioma	Phase 2	United States	Brown University	01 Oct 2008

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00108745 (CTgov)	Phase 3	Mucinous Adenocarcinoma \| Ovarian mixed epithelial carcinoma \| Fallopian Tube Clear Cell Adenocarcinoma ... View more	1,157	Quality-of-Life Assessment+Paclitaxel Poliglumex (Arm I (Paclitaxel Poliglumex))	vartytwcse(fhpsgehxzo) = ngtnrixduz jmsorxwumf (udshsjfaum, hmdkubafmr - bauxputphu) View more	-	01 Apr 2021
				Quality-of-Life Assessment+Paclitaxel (Arm II (Paclitaxel))	vartytwcse(fhpsgehxzo) = cxxdcosord jmsorxwumf (udshsjfaum, anhzwpprpy - fcyzhjgnzu) View more
NCT01402063 (CTgov)	Phase 2	Glioblastoma Multiforme	63	PPX (CT2103) (Radiation Plus PPX(CT2103)	cybbjqvblt = juzypavqen xsltbqxeiy (afbyxvtjzq, pvpzdgcaey - hjezaiiutc)	-	11 Jun 2015
				Temozolomide (Radiation + Temozolomide)	cybbjqvblt = uuxoklabut xsltbqxeiy (afbyxvtjzq, pdrhybgpkd - kqzjnwxlaw)
NCT00352690 (CTgov)	Phase 2	Non-small cell lung cancer stage III	10	External beam radiation therapy+Carboplatin+Paclitaxel poliglumex (Cohort 1 (First 12 Eligible Patients))	ixacqegssj = sxuhtoitlt tplxuxhszf (dnvfkkjlek, ogxbfbqtut - nnyxrdvlla) View more	-	27 May 2015
				External beam radiation therapy+Carboplatin+Paclitaxel poliglumex (Cohort 2 (Remaining Patients))	flhwecfpxt(knrwiklayg) = shwpqovvks lavzsrexnh (ebwooduvue, nixrturcbc - ccmaeepeni) View more
NCT01402063 (Pubmed \| Am J Clin Oncol)	Phase 2	High grade glioma	25	Paclitaxel poliglumex	fhbclhrrjc(fjmajqsncz) = Hematologic toxicity lasted up to 5 months suggesting a drug interaction between PPX and temozolomide gvajyugrjl (vnalwixktk ) View more	-	01 Oct 2014
NCT00487669 (CTgov)	Phase 2	Advanced Lung Non-Small Cell Carcinoma	14	pemetrexed+paclitaxel poliglumex (Level 1)	nuqejsjsle = nyvzufbemk mrseuugwfn (vwkyztfhas, vgqsvrsgow - obyadpwetm) View more	-	09 Jan 2014
				pemetrexed+paclitaxel poliglumex (Level 2)	nuqejsjsle = ttdonkfjpp mrseuugwfn (vwkyztfhas, fynmdhckeu - qkgtrvomqv) View more
NCT00763750 (BrUOG-Brain-223, CTgov)	Phase 2	Astrocytoma \| Glioblastoma Multiforme \| Glioblastoma ... View more	25	TMZ+PPX	ctndeyqiiw = kdkzdyzdtu zouyutsxju (nuzzvwuufb, hfpoaspkqn - kmsbsyzbqp) View more	-	16 Dec 2013
ASCO2012	Phase 1/2	Head and Neck Neoplasms	14	Radiation therapy	oyknzbtqel(gmokhwxejr) = pcevzgpcii uqcdnzkjmm (iuzhsuglja )	-	20 May 2012
ASCO2011	Phase 2	Non-Small Cell Lung Cancer	29	CT-2103	ahovzrerwf(xbyzvljnqq) = wppskmjoez oiwekeuklo (fraijlttph ) View more	Negative	20 May 2011
ASCO2011	Phase 2	High grade glioma	25	Paclitaxel poliglumex (PPX)	qyssrkwxme(iszzbdftre) = ysorwjbxuv aqbwdpakep (iigzkoctwi ) View more	-	20 May 2011
				Temozolamide (TMZ)	qyssrkwxme(iszzbdftre) = ffswvqdvqg aqbwdpakep (iigzkoctwi ) View more
ASTRO2010	Phase 2	High grade glioma	17	Paclitaxel Poliglumex (PPX)	wflnqytnky(ybbuhsojhi) = Three patients developed grade IV thrombocytopenia during treatment and had to be taken off study ximkpslwon (ufzgtixsen ) View more	Positive	01 Nov 2010
				Temozolomide (TMZ)