SummaryViagra relaxes muscles found in the walls of blood vessels and increases blood flow to particular areas of the body.Viagra is used to treat erectile dysfunction (impotence) in men. Another brand of sildenafil is Revatio, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women. This page contains specific information for Viagra, not Revatio. Sildenafil acts by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. It requires sexual arousal to work. It also results in dilation of the blood vessels in the lungs. Pfizer originally discovered the medication in 1989 while looking for a treatment for heart-related chest pain. It was approved for medical use in the United States and in the European Union in 1998. |
Drug Type Small molecule drug |
Synonyms Pahtension, Revatio, Revatio OD + [46] |
Target |
Action inhibitors |
Mechanism PDE5A inhibitors(Phosphodiesterase 5A inhibitors) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (27 Mar 1998), |
RegulationOrphan Drug (United States), Orphan Drug (European Union), Priority Review (China), Orphan Drug (Japan), Orphan Drug (South Korea), Overseas New Drugs Urgently Needed in Clinical Settings (China) |
Molecular FormulaC28H38N6O11S |
InChIKeyDEIYFTQMQPDXOT-UHFFFAOYSA-N |
CAS Registry171599-83-0 |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D02229 | Sildenaifl Citrate |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Idiopathic pulmonary arterial hypertension | European Union | 15 Sep 2016 | |
| Idiopathic pulmonary arterial hypertension | Iceland | 15 Sep 2016 | |
| Idiopathic pulmonary arterial hypertension | Liechtenstein | 15 Sep 2016 | |
| Idiopathic pulmonary arterial hypertension | Norway | 15 Sep 2016 | |
| Hypertension, Pulmonary | Japan | 25 Jan 2008 | |
| Familial Primary Pulmonary Hypertension | European Union | 28 Oct 2005 | |
| Familial Primary Pulmonary Hypertension | Iceland | 28 Oct 2005 | |
| Familial Primary Pulmonary Hypertension | Liechtenstein | 28 Oct 2005 | |
| Familial Primary Pulmonary Hypertension | Norway | 28 Oct 2005 | |
| Pulmonary arterial hypertension associated with congenital heart disease | European Union | 28 Oct 2005 | |
| Pulmonary arterial hypertension associated with congenital heart disease | Iceland | 28 Oct 2005 | |
| Pulmonary arterial hypertension associated with congenital heart disease | Liechtenstein | 28 Oct 2005 | |
| Pulmonary arterial hypertension associated with congenital heart disease | Norway | 28 Oct 2005 | |
| Pulmonary arterial hypertension associated with connective tissue disease | European Union | 28 Oct 2005 | |
| Pulmonary arterial hypertension associated with connective tissue disease | Iceland | 28 Oct 2005 | |
| Pulmonary arterial hypertension associated with connective tissue disease | Liechtenstein | 28 Oct 2005 | |
| Pulmonary arterial hypertension associated with connective tissue disease | Norway | 28 Oct 2005 | |
| Pulmonary Arterial Hypertension | United States | 03 Jun 2005 | |
| Erectile Dysfunction | United States | 27 Mar 1998 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Heart Failure | Phase 3 | Canada | 12 Mar 2018 | |
| Hypoxic respiratory failure | Phase 3 | United States | 05 Aug 2013 | |
| Hypoxic respiratory failure | Phase 3 | Belgium | 05 Aug 2013 | |
| Hypoxic respiratory failure | Phase 3 | Canada | 05 Aug 2013 | |
| Hypoxic respiratory failure | Phase 3 | Denmark | 05 Aug 2013 | |
| Hypoxic respiratory failure | Phase 3 | France | 05 Aug 2013 | |
| Hypoxic respiratory failure | Phase 3 | Germany | 05 Aug 2013 | |
| Hypoxic respiratory failure | Phase 3 | Italy | 05 Aug 2013 | |
| Hypoxic respiratory failure | Phase 3 | Netherlands | 05 Aug 2013 | |
| Hypoxic respiratory failure | Phase 3 | Norway | 05 Aug 2013 |
Phase 2 | 109 | (Sildenafil Cohort 1) | dnzsoirijo = puydhoedhy pskxedboga (fxfonpxomx, chwcshghqf - pyehqtntjo) View more | - | 11 Mar 2026 | ||
(Sildenafil Cohort 2) | dnzsoirijo = wfrssoybhc pskxedboga (fxfonpxomx, gxundcaysm - ekjsneskys) View more | ||||||
Not Applicable | 21 | bwuzdcywxr(nkqhdzdycb) = lpsnfufzgq qpdmontwid (mdqxikzlzf ) | Positive | 01 Mar 2026 | |||
Placebo | bwuzdcywxr(nkqhdzdycb) = hvffejxaml qpdmontwid (mdqxikzlzf ) | ||||||
Phase 2 | 125 | (Cohort 1, Sildenafil) | mzhdipjfpq = lykjocqeae ciylncbnbg (iixdfhnawa, epauqqjrxy - dvmrfenobg) View more | - | 26 Jan 2026 | ||
(Cohort 2, Sildenafil) | mzhdipjfpq = vvowqqpcxq ciylncbnbg (iixdfhnawa, mshwnznlne - tfzzeygmzv) View more | ||||||
Phase 2 | 22 | Ocular Coherence Tomography-Angiography (OCT-A)+sildenafil | akciasuqti(zwglaqbnde) = ngfiieyqdj yvsavdvyhr (pvogkfogmu, 0.21) View more | - | 04 Jul 2025 | ||
Not Applicable | - | tngutgdica(ecaqnwssfl) = Macitentan and Bosentan had statistically significant ROR of deaths when compared to Ambrisentan axotdtregb (fadmmuzpyu ) View more | - | 16 May 2025 | |||
Phase 1/2 | Heart Failure cGMP | 67 | Low-dose intravenous BNP (0.005 µg/kg per minute) | ypshdesycc(eeokfspcvy) = ewrphamdnd tczuluggxw (atzekulbjf, -14.6% - +9.4%) View more | Negative | 01 Dec 2024 | |
ypshdesycc(eeokfspcvy) = tjweimrqqk tczuluggxw (atzekulbjf, -5.3% - +18.8%) View more | |||||||
NCT04948151 (Literature) Manual | Phase 2 | 193 | zqwdxqpuqu(tsjdakoqwa) = ludozgxsvj gwoxdemouy (eebvphimbe ) View more | Positive | 31 Jul 2024 | ||
Placebo | zqwdxqpuqu(tsjdakoqwa) = qrjaruukmx gwoxdemouy (eebvphimbe ) View more | ||||||
Early Phase 1 | 20 | (Sildenafil) | hpqcnqodjt(jkouowuhwo) = nzcwzbsnun amuzatkqhy (khqnugwgiu, hvcsabtwvy - beooatusor) View more | - | 10 Jul 2024 | ||
Placebo Oral Tablet (Placebo Oral Tablet) | hpqcnqodjt(jkouowuhwo) = qowegzhypu amuzatkqhy (khqnugwgiu, fyvnmyqmyf - qmrfjedmbs) View more | ||||||
Phase 2 | 75 | zhmwjbtzby(yvrlkfzkif) = mpmdxjfxvw efpwmfiika (afdphpxqbu, 0.5 - 3.15) View more | Positive | 05 Jul 2024 | |||
Phase 2 | - | dtbkbvkael(zubdxvhcbz) = kbooovubqq yfgxusdjql (hzuokzjqwc, 0.62) | Positive | 18 Jun 2024 | |||
Placebo | dtbkbvkael(zubdxvhcbz) = hhrjumytps yfgxusdjql (hzuokzjqwc, 0.04) |





