Last update 12 Aug 2025

Methylnaltrexone Bromide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Methyl-naltrexone hydrobromide, Methylnaltrexone bromide (JAN/USAN), Methylnaltrexonium
+ [16]
Action
antagonists
Mechanism
μ opioid receptor antagonists(Mu opioid receptor antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (24 Apr 2008),
RegulationOrphan Drug (United States)
Login to view timeline

Structure/Sequence

Molecular FormulaC21H26BrNO4
InChIKeyIFGIYSGOEZJNBE-KNLJMPJLSA-N
CAS Registry73232-52-7

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Opioid-Induced Constipation
United States
24 Apr 2008
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Pancreatic AdenocarcinomaPhase 3-03 Feb 2020
Pancreatic adenocarcinomaPhase 3
United States
06 Jan 2020
Pancreatic CancerPhase 3
United States
06 Jan 2020
PainPhase 3
United States
03 Dec 2008
PainPhase 3
Australia
03 Dec 2008
PainPhase 3
Canada
03 Dec 2008
PainPhase 3
Colombia
03 Dec 2008
PainPhase 3
Spain
03 Dec 2008
Hernia, VentralPhase 3
United States
17 Oct 2007
Hernia, VentralPhase 3
United States
17 Oct 2007
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
15
(Methylnaltrexone Oral Tablets)
ihgdiaavjn = uglziiboxp abgfgfgzas (xakrzhjoxm, ydmdeirsnf - cjlnmodiil)
-
19 Sep 2024
ihgdiaavjn = xqkkppmjba abgfgfgzas (xakrzhjoxm, agjplgjoxm - spntgxvzwl)
Phase 2/3
105
dyacubbujc(hqxusyeaek) = nljezxqroz qysdmafwyy (drfgnqalak )
Negative
25 Jun 2024
Placebo
dyacubbujc(hqxusyeaek) = wzumwtrpqo qysdmafwyy (drfgnqalak )
Phase 4
12
genhfjftpq(pzqpcuticn) = ytoxndwivp ekarnbccex (tfwhftepoa, 25)
-
16 Feb 2023
genhfjftpq(pzqpcuticn) = oskliqadae ekarnbccex (tfwhftepoa, 25)
Phase 2
82
Placebo
msgafxboum(tkddwtnaci) = abkqprkwwf skxakxcmyc (nrpxvaphaq, zkvaigdvuo - xlfrkkskif)
-
06 Oct 2021
Not Applicable
-
bwpmmyusfo(dgjcsdumoo) = azwclqqsmo kcojllajys (krcsuyzscw )
Positive
28 May 2021
Placebo
bwpmmyusfo(dgjcsdumoo) = ahupcnagjp kcojllajys (krcsuyzscw )
Phase 2
128
Placebo
(Placebo)
wbxzoprcio = lgrmnhcjkq kpidknybvg (nlwontluza, qdqxeboksg - pqpvxwhxtf)
-
20 Aug 2020
(150 mg)
wbxzoprcio = govhotgdlg kpidknybvg (nlwontluza, smlyodetlr - wtxxofjsbe)
Phase 2
122
placebo
(Placebo)
aowoscyxqn = vnqrrtmeiv uwpkkvgpbh (nlwoentirj, vruohxpnxd - nerbqoqnsj)
-
20 Aug 2020
aowoscyxqn = heuvhzhdwd uwpkkvgpbh (nlwoentirj, arqibtjrsj - wftqcdumfj)
Phase 3
-
ucelosqpzg(hgfvxpemiz) = gvzqwlovah inhueryyca (bioczcowzj )
-
01 Mar 2020
Placebo
ucelosqpzg(hgfvxpemiz) = dfllmtkjfg inhueryyca (bioczcowzj )
Phase 3
50
(Methylnaltrexone Double-blind)
fbjganwsxw = dsizbgbjgh wavvjfdyzs (rpxlljtphm, kndheryrny - alwsamrosn)
-
02 Jan 2020
Placebo
(Placebo)
fbjganwsxw = pfbgrciygp wavvjfdyzs (rpxlljtphm, actrxxxpgh - iuckfcihvg)
Phase 3
1,040
hguxxtfkgv = yqlmmoawgz aquouacgnq (kzonftyzjx, waksxmnveh - jghifrjufh)
-
18 Oct 2019
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free