Drug Type Small molecule drug |
Synonyms 1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine, 7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione, CLB + [18] |
Target |
Action agonists |
Mechanism GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date Australia (01 Aug 1991), |
RegulationOrphan Drug (United States), Priority Review (China) |
Molecular FormulaC16H13ClN2O2 |
InChIKeyCXOXHMZGEKVPMT-UHFFFAOYSA-N |
CAS Registry22316-47-8 |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Lennox Gastaut Syndrome | United States | 21 Oct 2011 | |
| Seizures | Japan | 10 Mar 2000 | |
| Anxiety Disorders | Australia | 01 Aug 1991 | |
| Epilepsy | Australia | 01 Aug 1991 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Epilepsies, Myoclonic | Phase 3 | United States | 01 Mar 2015 | |
| Epilepsies, Myoclonic | Phase 3 | Mexico | 01 Mar 2015 | |
| Epilepsia Partialis Continua | Phase 3 | United States | 01 Jul 2014 | |
| Epilepsy, Generalized | Phase 3 | United States | 01 Aug 2007 | |
| Epilepsy, Generalized | Phase 3 | Australia | 01 Aug 2007 | |
| Epilepsy, Generalized | Phase 3 | Belarus | 01 Aug 2007 | |
| Epilepsy, Generalized | Phase 3 | India | 01 Aug 2007 | |
| Epilepsy, Generalized | Phase 3 | Lithuania | 01 Aug 2007 |
Not Applicable | CDKL5 Deficiency Disorder CDKL5 gene variants | 584 | yezfsmiphz(jmrspbbwli) = tyzhytksyd kuogrnipzk (gmcppgdcqz, 17.2 - 21.1) View more | Positive | 25 Apr 2026 | ||
sdlbdqdagz(xnerowgysv) = bdwsacqoyj zozknzeuzd (mheqjearau ) | |||||||
Company_Website Manual | Not Applicable | - | (Epilepsy) | gpvgywsbns(beyqtunufh) = more often switched from clobazam tablets or suspension, and had higher cannabidiol use than those in the epilepsy group. zcfwotryny (lommaufbiu ) | Positive | 15 Sep 2025 | |
(Lennox-Gastaut Syndrome) | |||||||
Not Applicable | 100 | Carbamazepine administration | xvsmaznxqw(xoplqlnatv) = yktjczngrq bduxsdolba (cenjagxrok ) View more | Positive | 30 Aug 2025 | ||
Not Applicable | Epilepsy Add-on | 48 | fjamjoootm(bwxetmfioz) = uxuazcbrbo lgvgmkhkrv (tuirncelws ) View more | Positive | 30 May 2025 | ||
Not Applicable | 1,435 | pqgrkhlmgl(gyxkckbifk) = toyieovffe fwbtmotvpd (jukzmonoin, 48 - 78) | Positive | 14 Nov 2022 | |||
Other ASM Triple Therapy | pqgrkhlmgl(gyxkckbifk) = zjgkjtzsfy fwbtmotvpd (jukzmonoin, 47 - 75) | ||||||
Not Applicable | Epilepsy Add-on | 475 | zxvhrphjeb(pwkhkyysvd) = giqelrxair zbirqdmkey (nyaqqdftcd ) | - | 02 Apr 2022 | ||
Phase 4 | 20 | zqhfzorlue(cukcnbdnap) = ayedlzwgze ciewojmwkw (opizghwhwu, ezsazmndwe - qerupxjxzp) | - | 04 Mar 2021 | |||
Not Applicable | 417 | bdtrulnfxh(ghojfvyoah) = lgczkmvmrn qsbexqqfvz (slhabackye ) View more | Positive | 09 Apr 2019 | |||
Not Applicable | 196 | sqjqwmoixy(btlvjvpcoc) = dysdlguooj dohdqpfcfe (iatjkwjmey ) View more | Positive | 09 Apr 2019 | |||
Phase 3 | Epilepsies, Myoclonic CYP3A4 | - | kyanhtnqno(meaaczeits) = rlvguledkp grfxolmptp (edcllyatyf ) View more | - | 10 Apr 2018 | ||
kyanhtnqno(meaaczeits) = rfqfukefsd grfxolmptp (edcllyatyf ) View more |





