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Last update 10 May 2026
Chlorhexidine Gluconate/Isopropyl Alcohol
Last update 10 May 2026
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms ChloraPrep, Soluprep |
Target- |
Action inhibitors |
Mechanism Cell membrane function inhibitors |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date United States (14 Jul 2000), |
Regulation- |
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Structure/Sequence
Molecular FormulaC3H8O |
InChIKeyKFZMGEQAYNKOFK-UHFFFAOYSA-N |
CAS Registry67-63-0 |
View All Structures (2)
Related
36
Clinical Trials associated with Chlorhexidine Gluconate/Isopropyl AlcoholNCT04756154
Assessment of the Antimicrobial Efficacy of 3M™ SoluPrep™ Preoperative Skin Preparation Against Resident Human Skin Flora on the Inguinal Region
NCT04218110
Preoperative Skin Preparation Study Following ASTM E1173 Methods to Evaluate the Antimicrobial Capabilities of Four Test Substances
NCT03489512
Clinical Phase IV Comparison Trial for 2% Chlorhexidine Skin Asepsis +70% Alcohol Versus Aqueous Chlorhexidine (2%) for the Prevention of Catheter-related Bacteremia in Critical Patients: Preliminary Study
100 Clinical Results associated with Chlorhexidine Gluconate/Isopropyl Alcohol
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100 Translational Medicine associated with Chlorhexidine Gluconate/Isopropyl Alcohol
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100 Patents (Medical) associated with Chlorhexidine Gluconate/Isopropyl Alcohol
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52
Literatures (Medical) associated with Chlorhexidine Gluconate/Isopropyl Alcohol17 Jul 2025British journal of nursing (Mark Allen Publishing)
Microbial safety of vapocoolant spray on sites for arterial line and epidural placement
Article
Author: Fayed, Mohamed ; Nowak, Katherine ; Wang, Anqi ; Woude, Thomas Vander ; Attali, Ami
This investigation evaluated if skin sterility is maintained following application of Gebauer's Ethyl Chloride® vapocoolant spray. In this prospective, blinded, controlled study, the medial forearm (site of arterial line placement) and lower back (site of epidural placement) were swabbed before and after sterilisation and treatment with vapocoolant. Data were collected from 72 participants. There was no difference in microbial abundance between samples obtained from the wrist with ChloraPrep™ versus ChloraPrep + Gebauer's Ethyl Chloride (P>0.99), or in positive cultures (P=0.317). On the lower back, there was no difference in microbial abundance following ChloraPrep versus ChloraPrep + Gebauer's Ethyl Chloride (P=0.317), or in positive cultures (P=0.317). Supply chain shortages of lidocaine have prompted consideration of alternative local anaesthetics. These findings support use of Gebauer's Ethyl Chloride as an alternative to lidocaine for minimally invasive procedures such as placement of arterial lines and epidurals. Further investigation is necessary to explore the safety of vapocoolants in more invasive procedures.
05 Nov 2024MILITARY MEDICINE
The Dreaded 3-Minute Wait: Does It Really Prevent Operating Room Fires? The IGNITE Trial
Article
Author: Fraley, Jim ; Danis, Hillary ; Keenan, Corey ; Spitzer, Holly ; Roets, Jack ; Grasso, Samuel
ABSTRACT:
Introduction:
Operating room fires can have devastating consequences and as such must be prevented. There exists a paucity of literature requiring further elucidation regarding manufacturer recommendations of a predefined waiting period prior to patient draping after using alcohol-based surgical antiseptics, in order to reduce the risk of operating room fires.
Methods:
This was further investigated by exposing two common alcohol-based surgical antiseptics to electrosurgery and open flames at various power settings and time intervals in an ex vivo porcine model. The simulated surgical site was prepped following manufacturer recommendations and exposed to monopolar electrosurgery at low and high power, using both PURE CUT and COAGULATION modes, and open flame, at 15-s increments after application.
Results:
While using PURE CUT mode at both low and high power, no ignition was observed on hairless surgical sites prepped with ChloraPrep® at any time point. However, use of COAGULATION mode at both low and high powers resulted in ignition consistently out to 1-min post-application. Additionally, if the prepped area subjectively appeared wet, especially with pooling of the antiseptic, both COAGULATION mode and open flame caused ignition. Dry time was found to be about 59 s for both prep solutions. It was also observed that the amount of pressure directly correlated with the amount of prep dispersed and increased dry times.
Conclusion:
In conclusion, our data suggest an average dry time of less than 1-min, with ignition only observed when the antiseptic was visibly wet. Ignition did not occur on hairless skin with electrocautery on CUT mode using ChloraPrep at any time point. Additionally, ignition on hair-bearing skin was not observed past 3 min, with current manufacturer recommendations stating 1 h wait time for hair-bearing skin. Arbitrarily waiting a specific predetermined dry time until patient draping, as recommended by the manufacturers, may be unnecessary and lead to hours’ worth of time wasted each year. Ongoing research will further investigate the utility of drying the antiseptic after application and its affect on not only preventing ignition but also antimicrobial efficacy.
01 Aug 2024JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
Hydrogen Peroxide May Reduce the Risk for Revision Surgery and Infection in Primary Shoulder Arthroplasty: Two-year Follow-up From a Prospective, Blinded, Controlled Trial
Article
Author: Joshua Mizels ; Daniel C. Lewis ; Peter N. Chalmers ; Robert Z. Tashjian
Background::
The purpose of this study was to determine whether the addition of hydrogen peroxide to the preoperative skin preparation for primary total shoulder arthroplasty is associated with a difference in patient-reported outcomes, risk for postoperative infection, and risk for revision surgery at a minimum of 2-year follow-up.
Methods::
This was a prospective, blinded, and controlled trial, which included a consecutive series of patients undergoing primary shoulder arthroplasty. The control group underwent standard sterile skin preparation using ethyl alcohol and ChloraPrep applicators, and the peroxide group had the same preparation with the addition of hydrogen peroxide between the alcohol and ChloraPrep applications. We then compared patient-reported outcome scores (American Shoulder and Elbow Surgeons Shoulder Score [ASES], simple shoulder test [SST], visual analog scale [VAS]), infections, and revision surgeries between the two groups at 2-year follow-up.
Results::
Of the 61 patients included in the original study, 52 of 58 (85%) living patients agreed to participate in this study. No preoperative differences were observed between groups. No difference was observed in ASES, SST, or VAS scores at 2 years. More revision surgeries were done in the control group (7 versus 2, P = 0.268) and Cutibacterium acnes infections (2 versus 0, P = 0.168).
Conclusion::
The addition of hydrogen peroxide to the preoperative skin preparation before primary shoulder arthroplasty is safe, and additional research is warranted to investigate whether it may decrease the risk for revision surgery and postoperative C acnes infection.
Level of Evidence::
III
100 Deals associated with Chlorhexidine Gluconate/Isopropyl Alcohol
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External Link
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
R&D Status
Approved
10 top approved records. to view more data
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| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Disinfectants | Australia | 26 Feb 2007 | |
| Skin Diseases, Bacterial | United States | 14 Jul 2000 |
Developing
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Joint Diseases | Clinical | United States | 26 Jan 2009 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
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Phase 4 | 8,485 | iodine (Closed-Fracture Population Iodine Group) | hmdprinxdl = utjffwolon mbqheuseez (yypaygfgrr, ohlbwwvybe - znyprkmvbg) View more | - | 04 Oct 2024 | ||
Chlorhexidine (Closed-Fracture Population Chlorhexidine Group) | hmdprinxdl = wuqzlqtvfu mbqheuseez (yypaygfgrr, fxtzgxnubp - qskpntmdaa) View more | ||||||
Phase 4 | 8,485 | cttokyansy(spabiwamnz) = dphdjdjkec lmyesgclgr (pwgllchade ) | Positive | 01 Feb 2024 | |||
(patients with a closed fracture) | cttokyansy(spabiwamnz) = lqauutjnek lmyesgclgr (pwgllchade ) | ||||||
Phase 3 | - | 154 | (CHG/IPA Surgical Skin Preparation) | dtupdndmoq(ymmnqzzkkx) = khsiydvhml afvfqfwyrv (jocorytzbr, 0.816) View more | - | 01 Aug 2023 | |
(Normal Saline) | dtupdndmoq(ymmnqzzkkx) = xbzunuwozk afvfqfwyrv (jocorytzbr, 0.411) View more | ||||||
Phase 2 | - | 28 | (3M CHG/IPA Prep / Center) | brewfhrwtp(uuladjverv) = dwptnwskgt pqvbuagrjj (yhvnqnuqdl, 1.31) View more | - | 27 Jun 2023 | |
(3M CHG/IPA Prep / Mid-peripheral) | quzbfzvtgu = ffkuwqqqis kaeeswoeow (uphzfiovku, zjwqlionmg - eznnigtqle) View more | ||||||
Phase 3 | - | 152 | (Project X 26ml) | erckhdfqho(ljvzlwnvvw) = ezeeefpujy kcfblecsau (nkbfhxafbb, 1.4) View more | - | 22 Oct 2021 | |
(Project X 5.1ml) | erckhdfqho(ljvzlwnvvw) = lrkpjjsdlx kcfblecsau (nkbfhxafbb, 1.3) View more | ||||||
Phase 3 | 329 | (Project X 26ml) | ecfiopjvcv(fefmqhlepd) = qijhcdejig xyrzrwvsfu (vbcyihfrel, 1.58) View more | - | 22 Oct 2021 | ||
(Project X 10.5ml) | ecfiopjvcv(fefmqhlepd) = sndrftikvq xyrzrwvsfu (vbcyihfrel, 1.48) View more | ||||||
Phase 3 | - | 170 | (Project X 26ml) | szarphuqiw(wnmmwdgegn) = zcdafpbpkc brkwciflxr (fttvpftzed, 1.42) View more | - | 22 Oct 2021 | |
(Project X 5.1ml) | szarphuqiw(wnmmwdgegn) = zhvlmzsxzi brkwciflxr (fttvpftzed, 1.56) View more | ||||||
Phase 3 | - | 335 | (CHG Swabstick (3 @ Once)) | njdcpdhupf(hnfsxbjpvn) = laxfurmnds lipbzebjpb (oyimuzzovz, 0.62) View more | - | 27 May 2021 | |
(CHG Swabstick Sequential) | njdcpdhupf(hnfsxbjpvn) = cynfegfkwf lipbzebjpb (oyimuzzovz, 0.64) View more | ||||||
Phase 4 | - | 20 | Chlorhexidine (Chlorhexidine Group) | pgallnjpcb = eubsksllfg ootggsynbv (ikdpxkawle, gayywmfzia - dgeplhviau) View more | - | 10 Jul 2013 | |
Iodophor+Iodine+IPA (Iodine Group) | pgallnjpcb = ejjcxtnjmw ootggsynbv (ikdpxkawle, nuhovsuips - anewyvooeb) View more | ||||||
Phase 4 | - | 22 | (ChloraPrep) | lvlxyiaewm(oevrvbjism) = kpwnudfdss jzdsfgeyhg (duzixenxiy, cdcqxhfeei - pqberhbdye) View more | - | 05 Mar 2013 | |
(DuraPrep) | lvlxyiaewm(oevrvbjism) = mdiusyluew jzdsfgeyhg (duzixenxiy, tcnagrfous - xcoadlscnj) View more |
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