Denosumab improves periprosthetic bone mineral density and bone strength after primary total hip arthroplasty by regulating the expression of bone type I collagen

Start Date01 Dec 2025

Sponsor / Collaborator-

NCT07242612

/ RecruitingNot ApplicableIIT

Determination of Selective Bone Turnover Markers and Their Association With Treatment Efficacy in Primary Postmenopausal Osteoporotic Women: A Randomized Control Trial

This study investigates the use of blood tests known as Bone Turnover Markers (BTMs) to quickly monitor the effectiveness of osteoporosis treatment in postmenopausal women. Osteoporosis, which weakens bones and increases fracture risk, is typically monitored using a DEXA scan to measure bone density (BMD), but this method changes slowly. BTMs may show a response to medication within just 3 to 6 months. In this randomized controlled trial, 40 postmenopausal women with osteoporosis will be assigned to receive either antiresorptive drugs (which slow bone loss) or anabolic drugs (which build new bone), along with calcium and vitamin D. The study will compare how these treatments affect BTMs and BMD over six months to determine if BTMs can serve as an early and reliable indicator of treatment success, which could be particularly useful in regions like Pakistan where access to repeated DEXA scans is limited.

Start Date01 Oct 2025

Sponsor / Collaborator

Khyber Medical University

CTRI/2025/07/091304

/ Not yet recruitingNot ApplicableIIT

Assessing the Impact of Short-Term Teriparatide on Osseointegration of Dental Implants in Patients with Poor Bone Quality: A Single-Blind Randomized Controlled Trial.

Start Date01 Aug 2025

Sponsor / Collaborator-

100 Clinical Results associated with Teriparatide(Eli Lilly)

100 Translational Medicine associated with Teriparatide(Eli Lilly)

100 Patents (Medical) associated with Teriparatide(Eli Lilly)

142

Literatures (Medical) associated with Teriparatide(Eli Lilly)

01 Sep 2025·BIOMATERIALS

All-in-one design of titanium-based dental implant systems for enhanced soft and hard tissue integration

Article

Author: Liu, Xuanyong ; Feng, Jiayin ; Ye, Kuicai ; Qian, Wenhao ; Qiu, Jiajun ; Xing, Min ; Zhang, Haifeng

Enhancing the sealing between titanium abutment and surrounding soft tissue is crucial for preventing peri-implantitis. Meanwhile, exploring non-invasive antibacterial strategies as alternatives for traditional antibiotic therapy is central to improving the effect of peri-implantitis treatment. Furthermore, facilitating effective integration between titanium implant and osteoporotic bone is the cornerstone for ensuring long-term implant stability in patients with osteoporosis. In light of this, this work innovatively constructed multifunctional vertical graphene-based coatings on titanium implants and abutments using plasma-enhanced chemical vapor deposition technology. The results demonstrated that the vertical graphene coatings promoted soft tissue sealing and exhibited inherent antibacterial activities with the bacteriostasis rates of 65.60 % against Staphylococcus aureus (S. aureus) and 43.89 % against Escherichia coli (E. coli) in vitro which could prevent early infections. Moreover, vertical graphene coatings presented photothermal antibacterial effects with the antibacterial rates of 99.99 % and 95.83 % for S. aureus in vitro and in vivo, respectively, and 92.23 % for E. coli in vitro under near-infrared irradiation, which provided a non-invasive and highly effective treatment option for peri-implantitis. Furthermore, teriparatide acetate was loaded on vertical graphene coatings which enhanced osseointegration between titanium implants and osteoporotic bone. By comprehensively considering the critical functional requirements of dental implants and abutments, this work meticulously designed vertical graphene-based coatings on titanium dental implant systems for soft and hard tissue integration. This innovative design demonstrates immense application potential, especially for dental implant restoration in patients with osteoporosis.

01 Jun 2025·Journal of Cachexia Sarcopenia and Muscle

Novel Aptamers Targeting Sclerostin Loop3 Improve Skeletal and Muscle Properties Without Adverse Cardiovascular Effects in Orchiectomized Mice

Article

Author: Xing, Xiaoping ; Hu, Jing ; Li, Mei ; Sun, Lei ; Xia, Weibo ; Jiang, Yan ; Wang, Luyao ; Yu, Yuanyuan ; Zhou, Bingna ; Zhang, Qian ; Zhang, Ge ; Wang, Yanye ; Wang, Ou

ABSTRACT:

Background:

The Wnt/β‐catenin pathway and its bone‐specific inhibitor, sclerostin, play important roles in skeletal development and homeostasis. The humanized sclerostin antibody, romosozumab, can significantly increase bone mineral density (BMD) of patients with osteoporosis, but it may also increase cardiovascular adverse events, particularly in male patients. We try to investigate the effects of novel aptamers targeting the sclerostin loop3 on the skeleton and muscle of orchiectomized (ORX) mice.

Methods:

After 12 weeks of ORX surgery, mice were randomly assigned to receive treatment with sclerostin aptamers (Apc001OA or Apc001OA‐d6), alendronate (ALN), teriparatide (PTH 1–34) or phosphate‐buffered saline (PBS). After 12 weeks of treatment, skeletal and muscle properties and safety indicators were evaluated in detail.

Results:

Treatment with Apc001OA and Apc001OA‐d6 significantly increased trabecular BMD at the femur by +11.9% and +17.1%, improved parameters of bone microarchitecture (BV/TV by +84.5% and +106.8%), bone strength (maximum load by +30.5% and +31.6%) and bone histological properties (all p < 0.05 vs. PBS group). The therapeutic effects were similar among Apc001OA, Apc001OA‐d6, ALN and PTH 1–34 groups (all p > 0.05). After treatment with Apc001OA or Apc001OA‐d6, serum sclerostin levels significantly decreased by 25.0% and 24.9% (p < 0.05 vs. PBS group). The expression levels of key genes in the Wnt/β‐catenin pathway, Ctnnb1 and Lef1 significantly increased by 2.4‐ and 3.4‐fold in the Apc001OA group and by 2.5‐ and 3.5‐fold in the Apc001OA‐d6 group (p < 0.05 vs. PBS group), indicating that the aptamers improved bone properties through activating Wnt/β‐catenin pathway. Apc001OA and Apc001OA‐d6 significantly improved rotarod latency (p < 0.05 vs. PBS group) of ORX mice, and Apc001OA‐d6 could increase forelimb grip strength. Apc001OA, Apc001OA‐d6 and PTH 1–34 improved histological properties of muscle in ORX mice. No lesions or pathological changes were observed in the heart, aortic roots, liver, spleen, lungs or kidneys. Immunohistochemistry revealed no abnormal staining of interleukin 6 (IL‐6) and tumour necrosis factor‐α (TNF‐α) in the heart. There was no significant difference in serum concentrations of cardiac functional biomarkers, including creatine kinase‐MB (CK‐MB), cardiac troponin I (cTnI), B‐type natriuretic peptide (BNP) and inflammatory mediators (IL‐6 and TNF‐α) across all groups, indicating that Apc001OA and Apc001OA‐d6 had no adverse cardiovascular effects in ORX mice.

Conclusions:

The novel aptamers Apc001OA and Apc001OA‐d6, targeting sclerostin loop3, could significantly increase BMD and improve bone microarchitecture, bone biomechanics, muscle function and histological properties of muscle and bone in ORX mice, without adverse cardiovascular effects. These aptamers may serve as potential agents for treating osteoporosis and sarcopenia in men.

12 Mar 2024·Journal of the Endocrine Society

Continuous Subcutaneous Delivery of rhPTH(1-84) and rhPTH(1-34) by Pump in Adults With Hypoparathyroidism

Article

Author: Cusano, Natalie E ; Mannstadt, Michael ; Bove-Fenderson, Erin ; Wong, Daniel ; Charoenngam, Nipith

Abstract:

Context:

Continuous subcutaneous infusion of recombinant parathyroid hormone (rhPTH) through a pump has been proposed as a therapeutic alternative for patients with chronic hypoparathyroidism who remain symptomatic or hypercalciuric on conventional treatment (calcium and active vitamin D) or daily injections of rhPTH(1-84) or rhPTH(1-34). However, the real-world evidence of the outcome of this novel therapy is limited.

Case Descriptions:

We report the clinical and biochemical outcomes of 12 adults with hypoparathyroidism (11 women, age 30-70 years, and 1 man, age 30 years) from 3 different clinical sites in the United States who were transitioned from conventional therapy to daily injections of rhPTH(1-84) or rhPTH(1-34) and then switched to continuous administration of rhPTH(1-84)/rhPTH(1-34) via pump therapy. In most patients, mean serum calcium concentrations increased while on PTH pump therapy compared with both conventional therapy (in 11 patients) and single/multiple daily rhPTH injections (in 8 patients). Despite this, 10 patients had lower median 24-hour urinary calcium levels while on PTH pump therapy compared with prior therapy (mean ± SD difference: −130 ± 222 mg/24 hours). All patients reported a qualitative decrease in hypocalcemic symptoms while receiving pump therapy. Three patients had pod failure at least once, and 1 patient developed an infusion site reaction.

Conclusion:

In this case series of 12 patients with chronic hypoparathyroidism treated with rhPTH(1-84)/rhPTH(1-34) administered via a pump, improvement in clinical and biochemical parameters were observed in the majority of the patients. Our observations indicate benefits of pump administration of rhPTH that warrant further investigation.

News (Medical) associated with Teriparatide(Eli Lilly)

08 Dec 2025

·www.prnewswire.com

EpiVax and FDA Scientists Publish New Insights on Immunogenicity Risks of Peptide-Related Impurities in Generic Teriparatide

PROVIDENCE, R.I., Dec. 8, 2025 /PRNewswire/ -- EpiVax, Inc., with U.S. Food and Drug Administration (FDA) and CUBRC, Inc. (Buffalo, NY) scientist collaborators, announces the publication of a study titled "Immunogenicity Risk Assessment of Peptide-Related Impurities Identified in Generic Teriparatide Products." The study uses a series of different tools to evaluate whether peptide-related impurities may influence unwanted immune responses in generic teriparatide (TPT)—an important consideration for ensuring the safety and comparability of generic peptide drugs. Teriparatide, a recombinant peptide used to treat osteoporosis, is among the peptide products highlighted in a recent FDA guidance that recommends that applicants assess immunogenicity risk for synthetic generics submitted under an abbreviated new drug application (ANDA). While establishing active pharmaceutical ingredient sameness is a key regulatory requirement, impurities arising from manufacturing processes may introduce sequence changes with the potential to generate new "T-cell epitopes". The study systematically evaluates teriparatide and several theoretical or observed impurities using the orthogonal methods of EpiVax's PANDA approach: in silico assessment (leveraging T-cell epitope prediction and characterization tools, EpiMatrix® and JanusMatrix®), in vitro HLA binding assays, and human T-cell assays. The investigators identified multiple impurities with higher predicted immunogenic potential than the reference teriparatide sequence, using the computational tools. Experimental analyses corroborated these predictions, revealing enhanced HLA binding and T-cell responses for several impurities compared to teriparatide itself. Notably, the study revealed a potentially tolerogenic region within the teriparatide sequence that may reduce responses to the drug, but that could be disrupted by sequence changes in the impurities. "This collaboration with FDA scientists underscores the power of combining robust computational and wet-lab methods to better understand and mitigate immunogenicity risks in generic peptide development," said Dr. Vibha Jawa (CSO, EpiVax). "Our findings offer a practical framework for developers navigating the FDA guidance on impurity assessment and highlight opportunities to strengthen peptide drug safety." The study may help generic peptide manufacturers identify impurities of concern that would contribute to immunogenicity and thus should be controlled in the generic drug product. FDA Funding Statement The research described was performed by EpiVax in collaboration with CUBRC, Inc. and FDA contributors, supported by FDA contract HHSF223018186C. The contents of this release are those of the author(s) and do not necessarily represent the official views of, nor an endorsement, by FDA/HHS, or the U.S. Government. Press Contact: Sarah Moniz Director, Business Development [email protected] Logo - 21% more press release views with Request a Demo

15 May 2025

·www.prnewswire.com

Abzena Announces Establishment of Scientific Advisory Board to Support Innovation Strategy

SAN DIEGO, May 15, 2025 /PRNewswire/ -- Abzena, the leading end-to-end integrated CDMO + CRO for complex biologics and bioconjugates, has announced today the formation of its Scientific Advisory Board (SAB) comprised of biopharma industry experts with diversified expertise in Discovery Research & Development (R&D) and Chemistry, Manufacturing, and Controls (CMC). The new advisory board will work closely with Abzena's scientific and commercial leadership to provide strategic guidance and expert insights that support Abzena's continued commitment to growth and innovation. Matt Stober, CEO of Abzena, said, "The establishment of the Scientific Advisory Board was a strategic decision to help guide the future of Abzena. We have seen considerable momentum over the past few years in supporting complex and innovative modalities, such as Antibody-drug conjugates (ADCs), Antibody-oligonucleotide conjugates (AOCs), and bispecifics. We aim to continue building upon this by offering the most state-of-the-art technologies and capabilities to support our customers' programs. These experts will be instrumental in assisting us with this mission by evaluating our strategies and providing recommendations that will further enhance our ability to move medicines forward to patients faster." Joe Principe, CCO of Abzena, said, "We are honored to welcome these distinguished individuals to our Scientific Advisory Board. These founding members are recognized leaders in our industry, bringing a wealth of expertise that will help guide us as we continue through this significant phase of our growth. We look forward to their contributions and the positive impact that they will have on our organization." Founding members of Abzena's Scientific Advisory Board are: John Knight, Ph.D., is the founder of JKONSULT, a UK-based consulting firm, where he provides process chemistry and CMC consulting services for early-stage chemical development and transfer-to-plant projects, with a primary focus on material supplies for toxicological studies, Phase I, and Phase II clinical trials. Dr Knight has 38 years of pharmaceutical industry experience, with prior roles at GSK, Vernalis, and Evotec. Kamal Egodage, Ph.D., MBA, is the President of Lasanth® Consulting, where he provides consultation services for biologics that span from discovery through commercialization, including CMC development, regulatory strategy, interactions with health authorities, and corporate development strategy. Prior to establishing his consultancy in 2017, Dr. Egodage accumulated over 20 years of industry experience at Eli Lilly, Pharmacia, Monsanto, Symic Bio, and Novartis (Switzerland), where he was the Head of Strategy and Business Development for Biologics. Morris Rosenberg, D.Sc., is an independent consultant with over 25 years of experience in the development of therapeutic agents to treat a variety of human diseases. As a consultant, he provides advisory services to early research and clinical-stage companies on product development strategies for biologics, biosimilars, and ADC therapies. Prior to this, Dr Rosenberg played a key role in the development and commercialization of ADC-based therapies at Seattle Genetics and Immunomedics and participated in the development and launch of Trodelvy®, Adcetris®, Avonex®, Angiomax®, Xigris®, and Forteo®. Scott Rudge, Ph.D., co-founded RMC Pharmaceutical Solutions in 2004, which was acquired by Syner-G BioPharma Group in January 2023. He is a Principal Consultant with Syner-G, and leads its Commercial and Scientific Advisory Boards, and is a member of the Syner-G Board. He also currently serves as SVP of Product Development at Margaux Biologics, Head of CMC for Antidote Therapeutics and Optigo Biotherapeutics, is a Key Advisor to Jurata, and is an Adjunct Professor of Chemical Engineering at the University of Colorado. Dr Rudge has over 33 years of experience directing Process Engineering, Process Development, Product Development, and overall Pharmaceutical Operations, and has built and led several organizations in the biopharmaceutical industry. Steven Sandoval is the founder and serves as the CEO/ Operations Head of Pharmaceutical Technical Solutions, Inc. (PTSI). Providing technical oversight and client representative support to the Biotechnology, Gene Therapy, Viral Vector, Cell Therapy, T-CELL, CAR T, mRNA, 503a/ 503b Compounding, and Vaccine Pharmaceutical Industries since 2010. Prior to this, he held senior leadership roles at Pfenex Inc., Parsons (BMS), and Amgen. He has over 30 years of experience in biopharmaceutical manufacturing, operations, CMC tech transfer, engineering, facilities, and quality leadership services. Tatyana Touzova is the Chief Pharmaceutical Development & Manufacturing Officer at SERA Medicines, where she oversees CMC, regulatory, and nonclinical development from drug discovery through clinical stages. Prior to this, she held the position of Chief Operating Officer at AstralBio, AlmataBio, and ValenzaBio, where she directed CMC, manufacturing, and regulatory operations for multiple clinical-stage programs. She has over 35 years of experience in drug development, regulatory affairs, and commercial manufacturing of biologics and complex therapeutics and is recognized as an expert in CMC strategy, GMP compliance, and global regulatory submissions. About Abzena Abzena is the leading end-to-end bioconjugate and complex biologics CDMO + CRO. From discovery through commercial launch, we support customers with fully integrated programs or individual services designed to de-risk and streamline the development of new treatments for patients in need. With the ability to tailor its strategy and customer experience to each project, Abzena develops and implements innovative solutions that enable biotech and biopharma companies to realize the full potential of their molecule and move medicines forward faster. The company has research, development, and cGMP facilities across locations in San Diego, CA, Bristol, PA, and Cambridge, UK. Abzena is owned by Welsh, Carson, Anderson & Stowe, one of the world's leading private equity investors. Learn more at abzena.com. SOURCE Abzena WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

AcquisitionPhase 2Executive Change

24 Oct 2024

·www.prnewswire.com

EpiVax and CUBRC Awarded FDA Contract Worth $2M for Development of Control Peptides for Immunogenicity Risk Assessment Assays Supporting Regulatory Filings of Generic Peptide Drugs

PROVIDENCE, R.I., Oct. 24, 2024 /PRNewswire/ -- EpiVax, Inc. ("EpiVax") and CUBRC, Inc. ("CUBRC") announce today that they have been awarded a two-year, $2 million contract (#75F40124C00094) from the Office of Generic Drugs (OGD) of the Food and Drug Administration (FDA) to develop standardized controls for T cell assays performed to assess the immunogenicity risk of generic drugs in support of ANDA applications as outlined in the relevant FDA guidance. The new contract will establish new "standards" that may be used to enhance specificity and sensitivity across industry assay methods. Generic peptide drugs (including generic versions of well-known brands like Ozempic and Wegovy) play a vital role in improving healthcare access by providing affordable and effective treatment options at a lower cost. FDA has been working to facilitate access to needed medicines at lower costs without sacrificing standards that result in high-quality, safe, and effective medications. See, for example, information provided by the FDA here. The new FDA-funded collaboration builds on research performed by EpiVax during two previous FDA contracts that evaluated the immunogenicity risk of generic drug impurities. Under the first contract, EpiVax demonstrated the value of in silico and in vitro methods for immunogenicity risk assessment of two well-known generic peptide drugs. Under the second contract, EpiVax developed the What-if Machine (WhIM), an algorithm designed to perform iterative modifications to the amino acid sequence of a synthetic peptide drug (in silico), generating a comprehensive list of impurities for that sequence, and prospectively identifying high and low risk impurities to allow for the de-risking of drug products. This information helps to 'frame' the risk for each generic drug and may assist drug developers and FDA reviewers to differentiate impurities that are potentially riskier from those that are lower risk. For the latest research program, EpiVax will identify and qualify standard peptide-sized positive and negative controls to support generic peptide drug ANDA applications for common generic drug peptides such as teriparatide, exenatide, liraglutide and tirzepatide. EpiVax's Peptide Abbreviated New Drug Application (PANDA ®) approach uses the same orthogonal methods utilized to identify and assess potentially immunogenic impurities for the FDA. The approach is described in a review titled "Immunogenicity Risk Assessment of Synthetic Peptide Drugs and Their Impurities." The details of one of the FDA-contracted programs were expanded upon in, "Assessing the Immunogenicity Risk of Salmon Calcitonin Peptide Impurities Using In Silico and In Vitro Methods." EpiVax looks forward to executing this latest FDA-funded research in collaboration with CUBRC and continuing to improve access to safe and effective generic peptide drug products by leading in the development of new industry standards for generic peptide drug immunogenicity assessment. About EpiVax EpiVax is a leader in the industry of immunogenicity assessment and sequence optimization for peptide therapeutics, biologic therapeutics, and vaccines. EpiVax partners with a global roster of companies, agencies, and academics to accelerate immunogenicity risk assessment, immune modulation and rapid vaccine design. Visit for more information. About CUBRC CUBRC is an independent not-for-profit scientific corporation that executes Research, Development, Testing and Systems Integration programs in Medical Sciences, Chemical and Biological Defense, Data Science and Information Fusion, Command and Control, and Hypersonics. Visit for more information. FDA Funding Statement The FDA sponsors the project referenced in this press release. The content of the information does not necessarily reflect the position or the policy of the federal government, and no official endorsement should be inferred. The entire project (~$2M) will be financed with federal money. Press Contact Sarah Moniz Director, Business Development EpiVax [email protected] Logo - WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

100 Deals associated with Teriparatide(Eli Lilly)

External Link

KEGG	Wiki	ATC	Drug Bank
D06078	Teriparatide(Eli Lilly)	H05AA02	DB06285

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Glucocorticoid-induced osteoporosis	Australia	Eli Lilly Australia Pty Ltd.	22 May 2003
Osteoporosis, Postmenopausal	Australia	Eli Lilly Australia Pty Ltd.	22 May 2003
Primary osteoporosis	Australia	Eli Lilly Australia Pty Ltd.	22 May 2003
Osteoporosis	South Korea	Lilly Korea Ltd.	12 Jul 2002

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Femoral Fractures	Phase 3	Canada	Eli Lilly & Co.	01 Jul 2013
Femoral Neck Fractures	Phase 3	United States	Eli Lilly & Co.	01 Jan 2012
Femoral Neck Fractures	Phase 3	Belgium	Eli Lilly & Co.	01 Jan 2012
Femoral Neck Fractures	Phase 3	Croatia	Eli Lilly & Co.	01 Jan 2012
Femoral Neck Fractures	Phase 3	France	Eli Lilly & Co.	01 Jan 2012
Femoral Neck Fractures	Phase 3	Germany	Eli Lilly & Co.	01 Jan 2012
Femoral Neck Fractures	Phase 3	Greece	Eli Lilly & Co.	01 Jan 2012
Femoral Neck Fractures	Phase 3	Hungary	Eli Lilly & Co.	01 Jan 2012
Femoral Neck Fractures	Phase 3	India	Eli Lilly & Co.	01 Jan 2012
Femoral Neck Fractures	Phase 3	Netherlands	Eli Lilly & Co.	01 Jan 2012

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


EULAR2025	Not Applicable	Osteoporosis, Postmenopausal \| Glucocorticoid-induced osteoporosis	54	Teriparatide	eyamwaqegk(xwpaswuimd) = khwdzzklgj zjmeumeuas (peduuufeqj ) View more	Positive	11 Jun 2025
FDA_CDER Manual	Not Applicable	Glucocorticoid-induced osteoporosis	428	Teriparatide	jrwbiwltvv(cykwgdzyin) = eyfjeqtidy xxltrnkxys (jddtpefzxu ) View more	Positive	04 Jun 2024
				prednisone or equivalent	-
FDA_CDER Manual	Not Applicable	Hypogonadal osteoporosis \| Primary osteoporosis	-	Teriparatide	ymlndslmco(cpqnvbzvpt) = zwnyhnsqrl hzcjmrbazq (pkziyqnabx ) View more	Positive	04 Jun 2024
				Placebo	ymlndslmco(cpqnvbzvpt) = mzfehfzvjw hzcjmrbazq (pkziyqnabx ) View more
FDA_CDER Manual	Not Applicable	Osteoporosis, Postmenopausal	1,637	Teriparatide	gtrvlfkkxr(dundicvwdu) = jpfdseyevw qxjccugjnr (svgimesvsg ) View more	Positive	04 Jun 2024
				Placebo	gtrvlfkkxr(dundicvwdu) = mmfovsztnk qxjccugjnr (svgimesvsg ) View more
WCO_IOF_ESCEO2024	Not Applicable	Spinal Fractures	48	Teriparatide treatment	mqzhtieinn(wlnyvmsxxe) = wwaqgmyvdj nmwmbimidt (qjhbvsvkaq ) View more	Positive	11 Apr 2024
				Placebo	lsqtnclvem(wnuciytgae) = povsiunsdp rqiqczmyww (uktnmzhgib )
SAT235 (ENDO2023)	Phase 1	-	29	RT-102/20 µg	hzuvuocagv(jwvexjxajp) = 3- to 4-fold higher compared to the SC injection group klwwpmjrji (fkqtglztci ) View more	Positive	05 Oct 2023
				RT-102/80 µg
NCT04026256 (CTgov)	Phase 4	Osteoporosis, Postmenopausal	37	Teriparatide (Teriparatide Only)	cqdmqzcbzr(xjfoaqrxjc) = omikfrjbzk zwfhosddgp (idlsmtgxzq, 0.06) View more	-	02 Aug 2023
				Denosumab (Denosumab Only)	cqdmqzcbzr(xjfoaqrxjc) = swhivkaawz zwfhosddgp (idlsmtgxzq, 0.01) View more
WCO_IOF_ESCEO2023	Not Applicable	Osteoporosis	-	Risedronate Gastric Resistant (RGR)	fmrdvchcjx(nxbrvkqcoe): IPTW IRR = 0.71 (95% CI, 0.31 - 1.62)	Positive	04 May 2023
				Oral Bisphosphonates with Immediate Release Formulations (BPIR)
WCO_IOF_ESCEO2023	Not Applicable	Osteoporotic Fractures	330	Denosumab 60 mg	gqmerykuvs(afdqpysqjw) = sxfcdwjbwk ausifmchli (kjygirmsgm )	Positive	04 May 2023
				Alendronic acid 70 mg	gqmerykuvs(afdqpysqjw) = pwnmlqcweh ausifmchli (kjygirmsgm )
WCO_IOF_ESCEO2021	Not Applicable	Osteoporosis procollagen type 1 N-terminal propeptide (P1NP)	83	Teriparatide 20 µg/d	alneaczijk(axlxrcabpq) = qimvvlwixx erkrdpgepp (emgrgtozwt ) View more	Positive	26 Aug 2021

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