Peramivir

— Q1 2026 ORLADEYO ® net revenue of $148.3 million (+11% y-o-y; +21% y-o-y on comparable basis excluding European revenue) — — Announced licensing agreement for European commercial rights to navenibart for $70M upfront and milestone payments up to $275M — RESEARCH TRIANGLE PARK, N.C., May 06, 2026 (GLOBE NEWSWIRE) -- BioCryst Pharmaceuticals, Inc. (Nasdaq:BCRX) today reported financial results for the quarter ended March 31, 2026, and provided a business update. “We began 2026 with continued strong execution across our business, led by sustained growth of ORLADEYO and solid progress across our pipeline,” said Charlie Gayer, President and Chief Executive Officer of BioCryst. “ORLADEYO continues to grow because its differentiated oral pro high level of attack control meet the needs of an increasing number of people living with hereditary angioedema. At the same time, we remain on track with enrollment in our navenibart and BCX17725 pipeline programs. We are also pleased to partner again with Neopharmed Gentili for European rights to navenibart. This progress underscores our strategy to focus on rare diseases where we have deep expertise, execute efficiently, and allocate capital thoughtfully to drive sustainable value for patients and shareholders.” Business & Corporate Updates New patient prescriptions in Q1 2026 continued to be strong, driving ORLADEYO revenue of $148.3 million (+11% y-o-y; +21% y-o-y on a comparable basis excluding European revenue). Patient enrollment in ALPHA-ORBIT, the ongoing pivotal study of navenibart in hereditary angioedema, is on track to be completed by the end of this June. The program remains on track to support regulatory filing in the US by the end of 2027. Navenibart is an investigational, long-acting plasma kallikrein inhibitor being studied with every three-month and every six-month subcutaneous dosing. In May, the company announced that it entered into a licensing agreement with an Irish affiliate of Neopharmed Gentili for exclusive rights to commercialize navenibart in Europe for the prophylaxis of hereditary angioedema. BioCryst will receive upfront consideration of $70M and will be eligible to receive up to $275M in future regulatory and sales milestone payments. BioCryst will also receive tiered royalties on net sales ranging from 18% to 30%. Navenibart is an investigational product that has not yet received regulatory approval in the US or Europe. The company is studying BCX17725, an investigational KLK5 inhibitor for the treatment of Netherton syndrome, in a Phase 1 trial. The company has begun dosing in Part 4 of this trial, which will enroll up to 12 patients for three months, and expects to report data from this part by the end of 2026. In Q1 2026, the company ended development of avoralstat, a plasma kallikrein inhibitor for the treatment of diabetic macular edema, to focus the pipeline on rare diseases. In April, the company appointed Sandeep M. Menon as Chief Research and Development Officer. Dr. Menon brings deep drug development expertise to the leadership team and will lead the company’s R&D efforts with a focused, disciplined, and capital efficient approach. First Quarter 2026 Financial Results On January 23, 2026, BioCryst completed the acquisition of Astria Therapeutics, Inc. (“Astria”). The transaction was accounted for as an asset acquisition and as a result, BioCryst recognized a special, non-cash expense of $697.8 million in Q1 2026 related to the acquired in-process research and development asset for navenibart. The accompanying tables provide GAAP and non-GAAP financial information. Non-GAAP measures include adjustments, as applicable, for the sale of the European ORLADEYO business on October 1, 2025, stock-based compensation, and expenses incurred in connection with the acquisition of Astria, including acquired in-process research and development expense, assembled workforce amortization, severance and retention related costs, and the portion of the Astria stock option payout attributable to post-combination service. Management believes that the presentation of these non-GAAP figures can provide greater transparency into the financial results of core, ongoing operations and improve comparability across reporting periods by excluding items that are non-recurring or other items that may vary significantly from period to period. BioCryst recorded a GAAP operating loss of $701.6 million for the first quarter of 2026, primarily reflecting the special, non-cash charge related to acquired in-process research and development. On a non-GAAP basis, the company recorded an operating profit of $54.2 million. Additional details on individual adjustments are included in the accompanying financial tables. Cash, cash equivalents, restricted cash and investments at March 31, 2026, totaled $260.8 million. On a pro-forma basis, including net proceeds of $70 million from the license of European navenibart rights to Neopharmed Gentili after quarter end, cash, cash equivalents, restricted cash and investments at March 31, 2026, totaled $330.8 million. Financial Outlook for 2026 The company maintained its expectation for full year 2026 global net ORLADEYO revenue to be between $625 million and $645 million and for full year 2026 total revenue, including RAPIVAB ® (peramivir injection), to be between $635 million and $660 million. The company also maintained its expectation for full year 2026 non-GAAP operating expenses, excluding stock-based compensation, restructuring, and transaction-related costs, to be between $450 million and $470 million. Item As of May 6, 2026 As of February 26, 2026 ORLADEYO revenue Unchanged $625 million to $645 million Total revenue Unchanged $635 million to $660 million Non-GAAP operating expense Unchanged $450 million to $470 million Conference Call and Webcast BioCryst management will host a conference call and webcast at 8:30 a.m. ET today to discuss the financial results and provide a corporate update. The live call may be accessed by dialing 1-844-481-2942 for domestic callers and 1-412-317-1866 for international callers. A live webcast and replay of the call will be available online in the investors section of the company website at . About BioCryst Pharmaceuticals BioCryst is a global biotechnology company focused on developing and commercializing medicines for hereditary angioedema (“HAE”) and other rare diseases, driven by its deep commitment to improving the lives of people living with these conditions. BioCryst has commercialized ORLADEYO ® (berotralstat), the first oral, once-daily plasma kallikrein inhibitor, and is advancing a pipeline of potential first-in-class or best-in-class oral small-molecule and injectable protein therapeutics for a range of rare diseases. For more information, please visit or follow us on LinkedIn . Non-GAAP Financial Measures The information furnished in this release and the accompanying tables includes non-GAAP financial measures that differ from measures calculated in accordance with generally accepted accounting principles in the United States of America (“GAAP”), including financial measures labeled as “non-GAAP.” As noted under “First Quarter 2026 Financial Results” above, we believe providing these non-GAAP measures, which show our results with certain items adjusted, is valuable and useful since they can provide greater transparency into the financial results of core, ongoing operations and improve comparability across reporting periods. These non-GAAP measures also correspond with the way we expect investors and financial analysts to compare our results. Our non-GAAP measures should be considered only as supplements to, and not as substitutes for or in isolation from, our other measures of financial information prepared in accordance with GAAP. A reconciliation between each non-GAAP financial measure and its respective closest equivalent GAAP financial measure is provided in the tables below. We also provide our non-GAAP operating expense outlook for full year 2026, which refers to our expected GAAP operating expense, excluding stock-based compensation, restructuring and transaction-related costs. We have not provided a reconciliation against the comparable forward-looking GAAP measure because we are unable to predict with reasonable certainty the full amount of stock-based compensation expense or restructuring or transaction-related costs for the full year 2026 without unreasonable effort. Stock-based compensation expense is uncertain and depends on various factors, including our future hiring and retention needs, as well as the future fair market value of our common stock, which is difficult to predict and subject to change. In addition, we are unable to predict with reasonable certainty the full amount of restructuring and transaction-related costs as the related costs are dependent on various factors that have not yet or have only recently occurred. The actual amount of stock-based compensation, restructuring and transaction-related costs for the full year 2026 could have a material impact on GAAP reported results for the guidance period. Forward-Looking Statements This press release contains forward-looking statements, including statements regarding future results, performance or achievements, such as expected full year 2026 revenue and operating expenses, expectations regarding pipeline development timing, including expected patient enrollment, regulatory filing, and data reporting timing, and potential future milestone payments. These statements involve known and unknown risks, uncertainties and other factors which may cause BioCryst’s actual results, performance, or achievements to be materially different from any future results, performance, or achievements expressed or implied by the forward-looking statements. These statements reflect our current views with respect to future events and are based on assumptions and are subject to risks and uncertainties. Given these uncertainties, you should not place undue reliance on these forward-looking statements. Some of the factors that could affect the forward-looking statements contained herein include: BioCryst’s ability to successfully progress its pipeline development plans as described herein, including meeting the expected timelines; ongoing and future preclinical and clinical development of product candidates may take longer than expected and may not have positive results; the outcome of preclinical testing and early clinical trials may not be predictive of the success of later clinical trials, and interim results of a clinical trial do not necessarily predict final results; BioCryst may not be able to enroll the required number of subjects in planned clinical trials of product candidates; BioCryst may not advance human clinical trials with product candidates as expected; the FDA or other applicable regulatory agency may require additional studies beyond the studies planned for products and product candidates, may not provide regulatory clearances which may result in delay of planned clinical trials, may not review regulatory filings on our expected timeline, may impose certain restrictions, warnings, or other requirements on products and product candidates, may impose a clinical hold with respect to product candidates, or may withhold, delay or withdraw market approval for products and product candidates; the results of BioCryst’s partnerships with third parties may not meet BioCryst’s current expectations, including that our partners may fail to reach performance milestones or achieve certain royalty thresholds under our license agreements; statements and projections regarding financial guidance and goals and the attainment of such goals may differ from actual results based on market factors and BioCryst’s ability to execute its operational and budget plans; and actual financial results may not be consistent with expectations, including that revenue, operating expenses and cash usage may not be within management’s expected ranges. This list is not exclusive. To see a more comprehensive list of risks, please refer to the documents BioCryst files periodically with the Securities and Exchange Commission, specifically BioCryst’s most recent Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, and Current Reports on Form 8-K, which identify important factors that could cause actual results to differ materially from those contained in BioCryst’s projections and forward-looking statements. BCRXW Contact: Investors: investorrelations@biocryst.com Media: media@biocryst.com BIOCRYST PHARMACEUTICALS, INC. CONSOLIDATED FINANCIAL SUMMARY (In thousands, except per share) Statements of Operations (Unaudited) Three Months Ended March 31, 2026 2025 Revenues: ORLADEYO $ 148,347 $ 134,243 License revenue 3,016 — Other revenues 5,050 11,291 Total revenues 156,413 145,534 Expenses: Cost of product sales 5,377 4,568 Acquired in-process research and development 697,761 — Research and development 60,319 37,270 Selling, general and administrative 94,554 82,469 Total operating expenses 858,011 124,307 (Loss) income from operations (701,598 ) 21,227 Other income (expense): Interest income 2,256 3,024 Interest expense (19,779 ) (23,494 ) Foreign currency (losses) gains, net (225 ) 1 Other expense, net (1,462 ) — Total other expense, net (19,210 ) (20,469 ) (Loss) income before income taxes (720,808 ) 758 Income tax expense 1,004 726 Net (loss) income $ (721,812 ) $ 32 Net (loss) income per common share: basic $ (2.98 ) $ 0.00 Weighted average shares of common stock outstanding: basic 242,258 208,882 Net (loss) income per common share: diluted $ (2.98 ) $ 0.00 Weighted average shares of common stock outstanding: diluted 242,258 215,261 Balance Sheet Data (in thousands) March 31, 2026 (unaudited) December 31, 2025 (Note 1) Cash, cash equivalents and investments $ 258,969 $ 335,911 Restricted cash 1,787 1,601 Receivables 109,272 106,818 Total assets 465,052 514,158 Secured term loan 395,197 — Royalty financing obligation 447,498 465,688 Accumulated deficit (2,227,991 ) (1,506,179 ) Stockholders’ deficit (553,843 ) (119,153 ) Shares of common stock outstanding 254,014 213,060 Note 1: Derived from audited financial statements. Reconciliations of Non-GAAP Income from Operations (in thousands) Three Months Ended March 31, 2026 U.S. GAAP Non-GAAP Adjustments 1 Non-GAAP Revenues: ORLADEYO $ 148,347 $ — $ 148,347 License revenue 3,016 — 3,016 Other revenues 5,050 — 5,050 Total revenues 156,413 — 156,413 Expenses: Cost of product sales - ORLADEYO 2,696 — 2,696 Cost of product sales - peramivir 2,681 — 2,681 Acquired in-process research and development 697,761 697,761 — Research and development (excluding stock-based compensation) 53,500 15,480 38,020 Sales and marketing (excluding stock-based compensation) 42,953 5,482 37,471 General and administrative (excluding stock-based compensation) 42,393 21,088 21,305 Stock-based compensation 16,027 16,027 — Total operating expenses 858,011 755,838 102,173 (Loss) income from operations $ (701,598 ) $ (755,838 ) $ 54,240 1 Reflects the following non-GAAP adjustments for the three months ended March 31, 2026: Expenses incurred in connection with the acquisition of Astria Therapeutics, Inc. on January 23, 2026: Acquired in-process research and development related to navenibart $ 697,761 Assembled workforce amortization $ 600 Expense associated with severance and retention award agreements $ 12,321 Portion of stock option payout attributable to post-combination service $ 29,129 Stock-based compensation $ 16,027 Three Months Ended March 31, 2025 U.S. GAAP Non-GAAP Adjustments 1 Non-GAAP Revenues: ORLADEYO $ 134,243 $ 11,536 $ 122,707 License revenue — — — Other revenues 11,291 — 11,291 Total revenues 145,534 11,536 133,998 Expenses: Cost of product sales - ORLADEYO 1,994 665 1,329 Cost of product sales - peramivir 2,574 — 2,574 Research and development (excluding stock-based compensation) 28,742 157 28,585 Sales and marketing (excluding stock-based compensation) 47,670 9,193 38,477 General and administrative (excluding stock-based compensation) 21,959 2,417 19,542 Stock-based compensation 21,368 21,368 — Total operating expenses 124,307 33,800 90,507 Income from operations $ 21,227 $ (22,264 ) $ 43,491 1 Represents revenues and expenses associated with our European ORLADEYO business which was sold to Neopharmed Gentili S.p.A. on October 1, 2025 and consolidated stock-based compensation.

—Full year 2025 ORLADEYO® net revenue of $601.8 million (+38% y-o-y; +43% y-o-y excluding European ORLADEYO revenue following the sale of the European ORLADEYO business to Neopharmed Gentili S.p.A. on October 1, 2025)— —Record GAAP and non-GAAP operating profit for full year 2025— —Maintained full year 2026 ORLADEYO revenue guidance between $625 and $645 million— —Received FDA approval for ORLADEYO oral pellets for patients with HAE Aged 2 to <12 Years— —Completed Acquisition of Astria Therapeutics— RESEARCH TRIANGLE PARK, N.C., Feb. 26, 2026 (GLOBE NEWSWIRE) -- BioCryst Pharmaceuticals, Inc. (Nasdaq:BCRX) today reported financial results for the full year ended December 31, 2025, and provided a business update. “2025 was fundamentally transformative for BioCryst. We achieved full-year profitability for the first time in the company’s history, driven by strong commercial execution that delivered the highest level of new patient prescriptions in the U.S. since the initial launch of ORLADEYO, even as the treatment landscape continued to evolve. We also advanced key business development initiatives that streamlined our operations and further strengthened our leadership position in hereditary angioedema. We entered 2026 with strong momentum, completing the acquisition of Astria Therapeutics to grow our HAE portfolio to meet the needs of more patients, while adding to our long-term growth trajectory well into the next decade,” said Charlie Gayer, President and Chief Executive Officer of BioCryst. Business Updates In October 2025, the company completed the sale of its European ORLADEYO business to Neopharmed Gentili S.p.A. The transaction enabled BioCryst to simplify its operating structure and sharpen its strategic focus on its core U.S. business. In December 2025, the company received FDA approval for the ORLADEYO pellet formulation for patients ages 2 to <12 with HAE, making it the first and only targeted oral prophylactic therapy for children living with HAE. In January 2026, the company completed its acquisition of Astria Therapeutics, Inc., initially announced in October 2025. Through the transaction, BioCryst added navenibart to its HAE portfolio. Navenibart is an injectable, long-acting, monoclonal antibody inhibitor of plasma kallikrein currently in Phase 3 clinical development for HAE prophylaxis. The navenibart Phase 3 program is currently enrolling and is on track to support regulatory filing by the end of 2027. The program consists of the ALPHA-ORBIT Phase 3 trial and the ORBIT-EXPANSE long-term trial. ALPHA-ORBIT is a randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of navenibart over a six-month treatment period, with dosing arms every three months (Q3M) and every six months (Q6M). After completing ALPHA-ORBIT, eligible participants may continue into the ORBIT-EXPANSE trial, in which all participants will receive navenibart in either Q3M or Q6M regimens. New positive, interim results from the long‑term, open‑label ALPHA‑SOLAR trial show sustained, robust HAE attack suppression with navenibart administered every three and six months. The mean and median HAE attack rate reductions from baseline were 92% and 97% in the Q3M dosing arm and 90% and 97% in the Q6M dosing arm. Long-term data up to 24 months show durable efficacy and a favorable safety pro both dosing regimens. BioCryst will present these results in a late-breaking presentation, and other abstracts, at the 2026 American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Meeting in Philadelphia, February 27–March 2, 2026. A Phase 1 trial of BCX17725, an investigational KLK5 inhibitor for the treatment of Netherton syndrome, is currently enrolling and has begun dosing patients. The company expects to report data from this program in up to 12 patients by the end of 2026. Full Year 2025 Financial Results Non-GAAP figures are provided with adjustments, as applicable, for the sale of the European ORLADEYO business, stock-based compensation, workforce reduction costs, and transaction-related costs. Management believes that the presentation of these non-GAAP figures can provide greater transparency into the financial results of core, ongoing operations and improve comparability across reporting periods by excluding both the impact of divestitures and other items that can vary significantly across time periods. Total revenues were $874.8 million and operating profit was $341.0 million for the full year 2025, compared to total revenues of $450.7 million and an operating loss of $2.5 million for the full year 2024. On October 1, 2025, BioCryst sold its European ORLADEYO business, resulting in the recognition of $243.3 million of revenue related to the license of intellectual property to Neopharmed Gentili S.p.A. On a non-GAAP basis, total revenues were $592.9 million (+45% y-o-y) and operating profit was $214.2 million (+198% y-o-y). Research and development expenses, excluding stock-based compensation expense, in 2025 were $136.6 million (-5% y-o-y) on a GAAP basis and $133.0 million (-5% y-o-y) on a non-GAAP basis. Research and development expenses included increases in program costs for BCX17725 and avoralstat driven by manufacturing and clinical activities as we advance our Phase 1 studies, as well as increased IND-enabling activities across our early-stage pipeline programs. These increases were offset by lower personnel related costs and the close out of the Factor D program. Sales and marketing expenses, excluding stock-based compensation expense, in 2025 were $177.1 (+16% y-o-y) million on a GAAP basis and $144.1 million (+23% y-o-y) on a non-GAAP basis. The increase was driven by distribution costs primarily attributed to increased sales, process development costs, the transition of certain safety and regulatory support roles from research and development due to commercial progression, pediatric launch support and other compensation expenses related to strong ORLADEYO sales performance. General and administrative expenses, excluding stock-based compensation expense, in 2025 were $116.0 million (+45% y-o-y) on a GAAP basis and $85.0 million (+21% y-o-y) on a non-GAAP basis. The increase was driven by compensation, headcount growth in certain functions, and the transition of certain quality support roles from research and development to general and administrative in connection with ORLADEYO’s continued commercial progression. Stock-based compensation increased due to a modification to extend the post-termination exercise period of certain vested stock option awards at the time of retirement for certain individuals to the original expiration date and an increase in restricted stock unit awards granted. Interest expense was $78.9 million for the full year 2025 (-20% y-o-y). The decrease was primarily driven by the payoff of the Pharmakon Term Loan in 2025 and a decrease in the effective interest rate during the period in which the debt was outstanding in 2025. The payoff of the Pharmakon Term Loan, totaling $323.7 million, resulted in a one-time loss on extinguishment of debt of $17.3 million for the full year 2025. Other income was $12.1 million for the full year 2025, which was primarily comprised of the impacts from the sale of our European ORLADEYO business. There was no other income for the full year 2024. Cash, cash equivalents, restricted cash and investments totaled $337.5 million at December 31, 2025. Net cash utilization for the full year 2025 was $5.4 million. Excluding the impacts of the payoff of the Pharmakon loan and related expenses totaling $333.6 million and the net proceeds from the sale of our European ORLADEYO business to Neopharmed Gentili S.p.A. totaling $243.0 million, there was $85.2 million of cash generated during 2025. Financial Outlook for 2026 The company maintained its expectation for full year 2026 global net ORLADEYO revenue to be between $625 million and $645 million and for full year 2026 total revenue, including RAPIVAB® (peramivir injection), to be between $635 million and $660 million. The company also maintained its expectation for full year 2026 non-GAAP operating expenses, excluding stock-based compensation, restructuring, and transaction-related costs, to be between $450 million and $470 million. Item As of February 26, 2026 As of January 12, 2026 ORLADEYO revenue Unchanged $625 million to $645 million Total revenue Unchanged $635 million to $660 million Non-GAAP operating expense Unchanged $450 million to $470 million Conference Call and Webcast BioCryst management will host a conference call and webcast at 8:30 a.m. ET today to discuss the financial results and provide a corporate update. The live call may be accessed by dialing 1-844-481-2942 for domestic callers and 1-412-317-1866 for international callers. A live webcast and replay of the call will be available online in the investors section of the company website at . About BioCryst Pharmaceuticals BioCryst is a global biotechnology company focused on developing and commercializing medicines for hereditary angioedema (“HAE”) and other rare diseases, driven by its deep commitment to improving the lives of people living with these conditions. BioCryst has commercialized ORLADEYO ® (berotralstat), the first oral, once-daily plasma kallikrein inhibitor, and is advancing a pipeline of potential first-in-class or best-in-class oral small-molecule and injectable protein therapeutics for a range of rare diseases. For more information, please visit or follow us on LinkedIn . Non-GAAP Financial Measures The information furnished in this release and the accompanying tables includes non-GAAP financial measures that differ from measures calculated in accordance with generally accepted accounting principles in the United States of America (“GAAP”), including financial measures labeled as “non-GAAP.” We believe providing these non-GAAP measures, which show our results with these items adjusted, is valuable and useful since they allow management and investors to better understand the company’s financial performance in the absence of certain non-cash items such as stock-based compensation and certain special events and allow investors to more accurately understand our current and past period results and more easily compare them to future results. These non-GAAP measures also correspond with the way we expect investors and financial analysts to compare our results. Our non-GAAP measures should be considered only as supplements to, and not as substitutes for or in isolation from, our other measures of financial information prepared in accordance with GAAP, such as GAAP revenue, operating income, net income, and earnings per share. Our references to non-GAAP operating income or profit, ORLADEYO net revenue, total revenue, research and development expenses, sales and marketing expenses, and general and administrative expenses constitute non-GAAP financial measures. These non-GAAP financial measures are calculated using our GAAP results, adjusted to show the results without including, as applicable, revenues and expenses associated with our European ORLADEYO business, license revenue related to the license of intellectual property to Neopharmed Gentili S.p.A., transaction-related costs, non-cash stock-based compensation expense, and workforce reduction expenses. A reconciliation between each non-GAAP financial measure and its respective closest equivalent GAAP financial measure is provided in the tables below. We also provide our non-GAAP operating expense outlook for full year 2026, which refers to our expected GAAP operating expense, excluding stock-based compensation, restructuring and transaction-related costs. We have not provided a reconciliation against the comparable forward-looking GAAP measure because we are unable to predict with reasonable certainty the full amount of stock-based compensation expense or restructuring or transaction-related costs for the full year 2026 without unreasonable effort. Stock-based compensation expense is uncertain and depends on various factors, including our future hiring and retention needs, as well as the future fair market value of our common stock, which is difficult to predict and subject to change. In addition, we are unable to predict with reasonable certainty the full amount of restructuring and transaction-related costs as the related costs are dependent on various factors that have not yet or have only recently occurred. The actual amount of stock-based compensation, restructuring and transaction-related costs for the full year 2026 could have a material impact on GAAP reported results for the guidance period. Forward-Looking Statements This press release contains forward-looking statements, including statements regarding future results, performance or achievements, including expected full year 2026 revenue and operating expenses, and expectations regarding pipeline development timing and BioCryst’s growth trajectory. These statements involve known and unknown risks, uncertainties and other factors which may cause BioCryst’s actual results, performance, or achievements to be materially different from any future results, performance, or achievements expressed or implied by the forward-looking statements. These statements reflect our current views with respect to future events and are based on assumptions and are subject to risks and uncertainties. Given these uncertainties, you should not place undue reliance on these forward-looking statements. Some of the factors that could affect the forward-looking statements contained herein include: BioCryst’s ability to successfully progress its pipeline development plans as described herein, including meeting the expected timelines; ongoing and future preclinical and clinical development of product candidates may take longer than expected and may not have positive results; the outcome of preclinical testing and early clinical trials may not be predictive of the success of later clinical trials, and interim results of a clinical trial do not necessarily predict final results; BioCryst may not be able to enroll the required number of subjects in planned clinical trials of product candidates; BioCryst may not advance human clinical trials with product candidates as expected; the FDA or other applicable regulatory agency may require additional studies beyond the studies planned for products and product candidates, may not provide regulatory clearances which may result in delay of planned clinical trials, may not review regulatory filings on our expected timeline, may impose certain restrictions, warnings, or other requirements on products and product candidates, may impose a clinical hold with respect to product candidates, or may withhold, delay or withdraw market approval for products and product candidates; statements and projections regarding financial guidance and goals and the attainment of such goals may differ from actual results based on market factors and BioCryst’s ability to execute its operational and budget plans; and actual financial results may not be consistent with expectations, including that revenue, operating expenses and cash usage may not be within management’s expected ranges. This list is not exclusive. To see a more comprehensive list of risks, please refer to the documents BioCryst files periodically with the Securities and Exchange Commission (the “SEC”), specifically BioCryst’s most recent Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, and Current Reports on Form 8-K, which identify important factors that could cause actual results to differ materially from those contained in BioCryst’s projections and forward-looking statements. BCRXW Contact: Investors: investorrelations@biocryst.com Media: media@biocryst.com BIOCRYST PHARMACEUTICALS, INC. CONSOLIDATED FINANCIAL SUMMARY (In thousands, except per share) Statements of Operations (Unaudited) Three Months Ended December 31, Twelve Months Ended December 31, 2025 2024 2025 2024 Revenues: ORLADEYO $ 151,682 $ 124,186 $ 601,839 $ 437,660 License revenue 243,980 — 243,980 — Other revenues 10,893 7,348 29,018 13,052 Total revenues 406,555 131,534 874,837 450,712 Expenses: Cost of product sales 9,522 6,094 19,075 12,269 Research and development 40,867 49,441 166,126 174,638 Selling, general and administrative 95,781 80,507 348,647 266,348 Total operating expenses 146,170 136,042 533,848 453,255 Income (loss) from operations 260,385 (4,508 ) 340,989 (2,543 ) Other income (expense): Interest income 2,890 3,570 10,668 14,746 Interest expense (14,135 ) (24,449 ) (78,872 ) (98,516 ) Foreign currency losses, net (125 ) (604 ) (152 ) (641 ) Loss on extinguishment of debt (10,421 ) — (17,332 ) — Other income 9,423 — 12,090 — Total other expense, net (12,368 ) (21,483 ) (73,598 ) (84,411 ) Income (loss) before income taxes 248,017 (25,991 ) 267,391 (86,954 ) Income tax expense 2,172 804 3,530 1,927 Net income (loss) $ 245,845 $ (26,795 ) $ 263,861 $ (88,881 ) Net income (loss) per common share: basic $ 1.17 $ (0.13 ) $ 1.26 $ (0.43 ) Weighted average shares of common stock outstanding: basic 210,969 207,381 209,893 206,696 Net income (loss) per common share: diluted $ 1.12 $ (0.13 ) $ 1.21 $ (0.43 ) Weighted average shares of common stock outstanding: diluted 219,263 207,381 218,581 206,696 Balance Sheet Data (in thousands) December 31, 2025 (unaudited) 2024 (Note 1) Cash, cash equivalents and investments $ 335,911 $ 341,173 Restricted cash 1,601 1,610 Receivables 106,818 79,069 Total assets 514,158 490,420 Secured term loan — 314,869 Royalty financing obligation 465,688 513,729 Accumulated deficit (1,506,179 ) (1,770,040 ) Stockholders’ deficit (119,153 ) (475,934 ) Shares of common stock outstanding 213,060 208,543 Note 1: Derived from audited financial statements. Reconciliations of Non-GAAP Income (Loss) from Operations (in thousands) Twelve Months Ended December 31, 2025 U.S. GAAP European ORLADEYO Business 1 Other Non-GAAP Adjustments 2 Non-GAAP Revenues: ORLADEYO: U.S. $ 548,779 $ — $ — $ 548,779 Outside of U.S. 53,060 38,658 — 14,402 Total ORLADEYO 601,839 38,658 — 563,181 License revenue 243,980 — 243,271 709 Other revenues 29,018 — — 29,018 Total revenues 874,837 38,658 243,271 592,908 Expenses: Cost of product sales 19,075 2,465 9 16,601 Research and development (excluding stock-based compensation) 136,616 1,539 2,040 133,037 Sales and marketing (excluding stock-based compensation) 177,085 30,495 2,502 144,088 General and administrative (excluding stock-based compensation) 116,006 8,089 22,912 85,005 Stock-based compensation 85,066 — 85,066 — Total operating expenses 533,848 42,588 112,529 378,731 Income (loss) from operations $ 340,989 $ (3,930 ) $ 130,742 $ 214,177 1 Represents revenues and expenses associated with our European ORLADEYO business which was sold to Neopharmed Gentili S.p.A. on October 1, 2025. 2 Reflects the following non-GAAP adjustments for the twelve months ended December 31, 2025: License revenue related to the license of intellectual property to Neopharmed Gentili S.p.A. $ 243,271 Transaction-related costs $ 21,149 Workforce reduction expense $ 6,314 Stock-based compensation $ 85,066 Twelve Months Ended December 31, 2024 U.S. GAAP European ORLADEYO Business 1 Other Non-GAAP Adjustments 2 Non-GAAP Revenues: ORLADEYO: U.S. $ 385,961 $ — $ — $ 385,961 Outside of U.S. 51,699 43,130 — 8,569 Total ORLADEYO 437,660 43,130 — 394,530 License revenue — — — — Other revenues 13,052 — — 13,052 Total revenues 450,712 43,130 — 407,582 Expenses: Cost of product sales 12,269 2,879 — 9,390 Research and development (excluding stock-based compensation) 143,353 2,723 1,201 139,429 Sales and marketing (excluding stock-based compensation) 152,166 35,252 — 116,914 General and administrative (excluding stock-based compensation) 80,054 9,999 63 69,992 Stock-based compensation 65,413 — 65,413 — Total operating expenses 453,255 50,853 66,677 335,725 Income (loss) from operations $ (2,543 ) $ (7,723 ) $ (66,677 ) $ 71,857 1 Represents revenues and expenses associated with our European ORLADEYO business which was sold to Neopharmed Gentili S.p.A. on October 1, 2025. 2 Reflects the following non-GAAP adjustments for the twelve months ended December 31, 2024: Workforce reduction expense $ 1,264 Stock-based compensation $ 65,413 Three Months Ended December 31, 2025 U.S. GAAP European ORLADEYO Business 1 Other Non-GAAP Adjustments 2 Non-GAAP Revenues: ORLADEYO: U.S. $ 146,725 $ — $ — $ 146,725 Outside of U.S. 4,957 — — 4,957 Total ORLADEYO 151,682 — — 151,682 License revenue 243,980 — 243,271 709 Other revenues 10,893 — — 10,893 Total revenues 406,555 — 243,271 163,284 Expenses: Cost of product sales 9,522 — 9 9,513 Research and development (excluding stock-based compensation) 35,731 — 2,040 33,691 Sales and marketing (excluding stock-based compensation) 39,712 — 2,185 37,527 General and administrative (excluding stock-based compensation) 37,412 — 13,296 24,116 Stock-based compensation 23,793 — 23,793 — Total operating expenses 146,170 — 41,323 104,847 Income (loss) from operations $ 260,385 $ — $ 201,948 $ 58,437 1 No revenues or expenses for the three months ended December 31, 2025, as we sold our European ORLADEYO business to Neopharmed Gentili S.p.A. on October 1, 2025. 2 Reflects the following non-GAAP adjustments for the three months ended December 31, 2025: License revenue related to the license of intellectual property to Neopharmed Gentili S.p.A. $ 243,271 Transaction-related costs $ 11,216 Workforce reduction expense $ 6,314 Stock-based compensation $ 23,793 Three Months Ended December 31, 2024 U.S. GAAP European ORLADEYO Business 1 Other Non-GAAP Adjustments 2 Non-GAAP Revenues: ORLADEYO: U.S. $ 106,974 $ — $ — $ 106,974 Outside of U.S. 17,212 12,957 — 4,255 Total ORLADEYO 124,186 12,957 — 111,229 License revenue — — — — Other revenues 7,348 — — 7,348 Total revenues 131,534 12,957 — 118,577 Expenses: Cost of product sales 6,094 743 — 5,351 Research and development (excluding stock-based compensation) 39,079 143 — 38,936 Sales and marketing (excluding stock-based compensation) 39,702 9,833 — 29,869 General and administrative (excluding stock-based compensation) 29,828 3,644 — 26,184 Stock-based compensation 21,339 — 21,339 — Total operating expenses 136,042 14,363 21,339 100,340 Income (loss) from operations $ (4,508 ) $ (1,406 ) $ (21,339 ) $ 18,237 1 Represents revenues and expenses associated with our European ORLADEYO business which was sold to Neopharmed Gentili S.p.A. on October 1, 2025. 2 Reflects the following non-GAAP adjustment for the three months ended December 31, 2024: Stock-based compensation $ 21,339