Last update 12 Jun 2025

Cefazolin Sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cefazo1in Sodium, Cefazolin, Cefazolin sodium (JP17/USP)
+ [24]
Target
Action
inhibitors
Mechanism
PBPs inhibitors(Bacterial penicillin-binding protein inhibitors), Cell wall inhibitors
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (04 Oct 1973),
Regulation-
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Structure/Sequence

Molecular FormulaC14H24N8NaO9S3
InChIKeyCQCPLXCVNXNUCK-HGUWTHONSA-N
CAS Registry115850-11-8

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Biliary tract infection
United States
27 Jul 2000
Bone and joint infections
United States
27 Jul 2000
Endocarditis
United States
27 Jul 2000
Genital infection
United States
27 Jul 2000
Respiratory Tract Infections
United States
27 Jul 2000
Sepsis
United States
27 Jul 2000
Skin and skin structure infections
United States
27 Jul 2000
Surgical Wound Infection
United States
27 Jul 2000
Urinary Tract Infections
United States
27 Jul 2000
Bacterial Infections
China
01 Jan 1984
Gram-Negative Bacterial Infections
United States
04 Oct 1973
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
12
qbwhngebyn(ligdcuiwcf) = qulxfpyupg uhlgjcslmy (wkaypsgrix, 702)
-
28 Feb 2025
Phase 4
160
(Pre-operative Antibiotics)
jgpxdrmkgj = btbgftethn xnfboyakir (opypmagpjp, vnniuhgrpk - zrvhbmlnsq)
-
09 Aug 2024
(Saline Placebo)
jgpxdrmkgj = cytokhqnlo xnfboyakir (opypmagpjp, uacyitpyyu - wgffqteqbq)
Early Phase 1
186
(Cefazolin + Azithromycin)
hgbmyunhhb = cigxxzyaqk vpjwknccar (iwjfbxnnob, nzyqlvlezh - tcyvybklzu)
-
19 Apr 2024
Placebo
(Placebo + Placebo)
hgbmyunhhb = tcutlxgsuj vpjwknccar (iwjfbxnnob, khkswsrxcw - dojolvlhnt)
Phase 4
86
(Peri-Articular Injections Only)
dmnaladymw(husnaibszd) = vnsqqjxveu tvnaunsjho (vlkzeoezsh, 1.7)
-
23 Jan 2024
(Peri-Articular Injections, Adductor Canal Block, and IPACK)
dmnaladymw(husnaibszd) = mbphtuezjr tvnaunsjho (vlkzeoezsh, 1.4)
Phase 4
12
Paraspinal muscle microdialysis catheters+Bolus dose of Cefazolin
(First Regimen Group)
zsnviztfbx(omgmssjowx) = lbikaduwqv pssexjjstp (fpyiuphpzw, alibtrkmsl - kyfkbcjdxd)
-
11 Jul 2023
Paraspinal muscle microdialysis catheters+Continuous Cefazolin drip
(Second Regimen Group)
zsnviztfbx(omgmssjowx) = zlgxswgusi pssexjjstp (fpyiuphpzw, kxtunbztka - hkgfzaigrw)
Phase 2
50
antibiotics
(Arm A: No Antibiotic Prophylaxis Prior to Skin Incision)
ylqcsuffrv = tkwnsdcpcl zggjvighhm (ftblwjvsvn, dhbpgkrzmy - nxvayvgbze)
-
21 Nov 2022
(Arm B: Antibiotic Prophylaxis Prior to Skin Incision)
ylqcsuffrv = ikchaxhnhz zggjvighhm (ftblwjvsvn, sitdmngiiq - kwxtjggcjr)
Phase 4
11
antibiotics
(Control)
ntqognlscv = blysybgday strqidmric (czbjpvhxkp, dezycnkyhh - hliawzgkrg)
-
07 Oct 2021
ntqognlscv = auvcughokb strqidmric (czbjpvhxkp, guwwmtgqai - jvzcgymulq)
Phase 4
30
oaclibuqgj(cgpszykwti) = vqagwcqyci wzqcvusfml (qdobnhgygo, qblulvtnyz - lfugmhbfhk)
-
02 Feb 2021
Phase 4
61
(Cefazolin 1 g Infusion)
hyadtduuil = qehrdqchxn rjhnbawugq (bpgdxkrumd, dabomzzzcy - dpfwrfqzzi)
-
13 Mar 2020
(Cefazolin 2 g Infusion)
hyadtduuil = rnbrdgpmzc rjhnbawugq (bpgdxkrumd, jsmkycmhia - mfevzqbqop)
Phase 4
144
IP cefepime monotherapy
xetnxexoyh(bvelrmfkjn) = cimtshcpws mvqafqzpfw (vkhaezhtam )
-
01 Nov 2019
IP combination of cefazolin and ceftazidime
xetnxexoyh(bvelrmfkjn) = kbacfrxcbd mvqafqzpfw (vkhaezhtam )
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Approval

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Regulation

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