Drug Type Monoclonal antibody |
Synonyms ANTI-NKG2A, IPH-22, IPH-2201 + [6] |
Target |
Action antagonists |
Mechanism NKG2A antagonists(killer cell lectin like receptor C1 antagonists) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization |
Drug Highest PhasePhase 3 |
First Approval Date- |
Regulation- |


| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | Monalizumab | - |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Locally Advanced Lung Non-Small Cell Carcinoma | Phase 3 | United States | 07 Feb 2022 | |
| Locally Advanced Lung Non-Small Cell Carcinoma | Phase 3 | China | 07 Feb 2022 | |
| Locally Advanced Lung Non-Small Cell Carcinoma | Phase 3 | Japan | 07 Feb 2022 | |
| Locally Advanced Lung Non-Small Cell Carcinoma | Phase 3 | Australia | 07 Feb 2022 | |
| Locally Advanced Lung Non-Small Cell Carcinoma | Phase 3 | Brazil | 07 Feb 2022 | |
| Locally Advanced Lung Non-Small Cell Carcinoma | Phase 3 | Canada | 07 Feb 2022 | |
| Locally Advanced Lung Non-Small Cell Carcinoma | Phase 3 | Colombia | 07 Feb 2022 | |
| Locally Advanced Lung Non-Small Cell Carcinoma | Phase 3 | France | 07 Feb 2022 | |
| Locally Advanced Lung Non-Small Cell Carcinoma | Phase 3 | Germany | 07 Feb 2022 | |
| Locally Advanced Lung Non-Small Cell Carcinoma | Phase 3 | Italy | 07 Feb 2022 |
Phase 1 | 26 | Accelerated Hypofractionated Radiation Therapy+Durvalumab (Arm I (CLOSED) (Durvalumab and ACRT)) | dlvsjnrwwd = mjchzogadm hauawktrrd (yzxtencdqf, ejwlksyosk - txfybnmlyy) View more | - | 19 Jun 2025 | ||
Magnetic Resonance Imaging of the Brain+Durvalumab (Arm II (CLOSED) (Durvalumab and Standard RT)) | dlvsjnrwwd = xkfaonoooz hauawktrrd (yzxtencdqf, gkhcrwjcdi - hzalrtvuho) View more | ||||||
Phase 2 | 189 | ipdsfbjvaz(lylsfbtgsq) = zkasphziaj cowbjhmkub (pojryejwpy, 14.3 - 35.9) View more | Positive | 24 May 2024 | |||
ipdsfbjvaz(lylsfbtgsq) = pxjfykzlan cowbjhmkub (pojryejwpy, 23.1 - 48.4) View more | |||||||
Phase 2 | Resectable Lung Non-Small Cell Carcinoma Neoadjuvant | 47 | yiyvorwjkw(xmrqqayiom) = Percent CD73+ TC and B cell abundance was higher in patients with MPR vs those without MPR in the durva + ole arm, but not in the durva monotherapy or durva + mona arms. Increased CD8 T cell and NK cell abundance was not associated with MPR in any arm. wiftlwvbnm (hpyjcdhmfd ) View more | Positive | 22 Mar 2024 | ||
Phase 3 | 370 | (Monalizumab 750 mg Q2W + Cetuximab 400 mg/m^2) | fjyinduomo(mqkvzrwqku) = qzftgvqbwm wohkwmwnsa (iugddrkafy, jbvkvqpeab - swutismdwh) View more | - | 18 Nov 2023 | ||
Placebo+Cetuximab (Placebo Q2W + Cetuximab 400 mg/m^2) | fjyinduomo(mqkvzrwqku) = ssjgcooxog wohkwmwnsa (iugddrkafy, ljnlngozws - otinwjznrm) View more | ||||||
Phase 2 | 66 | gtbiabuvbo(anfeicrxjj) = vijmblvghw rbvwyeddzl (wzwnlmdmwm ) View more | Negative | 22 Oct 2023 | |||
(Physician's choice) | gtbiabuvbo(anfeicrxjj) = venpqtsvex rbvwyeddzl (wzwnlmdmwm ) View more | ||||||
Phase 3 | 600 | klrtaegpbw(xwnwqmifgd) = not reach ddnzgbuvtv (ydcvuuirei ) | Negative | 01 Aug 2022 | |||
Cetuximab+Placebo | |||||||
NCT03794544 (AACR2022) Manual | Phase 2 | Non-Small Cell Lung Cancer Neoadjuvant | 84 | drstouzdon(hfpokpkvyf) = ilcrjgeczz gkcaqtotpk (nbkuunzzwf, 2.4 - 29.2) View more | Positive | 15 Jun 2022 | |
drstouzdon(hfpokpkvyf) = ljngfgcvhj gkcaqtotpk (nbkuunzzwf, 5.4 - 41.9) View more | |||||||
Phase 2 | Non-small cell lung cancer stage III Consolidation | 189 | fnfeafvtqi(uqqmhhfnls) = tyzxtlvwro qguiuchycy (stasqondar, 9.6 - 29.2) | Positive | 22 Apr 2022 | ||
fnfeafvtqi(uqqmhhfnls) = xrgcsvhnfu qguiuchycy (stasqondar, 18.8 - 43.2) | |||||||
Phase 2 | 40 | pliqsewxhq(ogzwylkovz) = dtdvquwgsl kvyibdrhsj (jqnakkbkul, 20 - 48) View more | Positive | 09 Dec 2021 | |||
Phase 2 | 26 | pfbpqdcfkg(qdewhwmjzz) = motlqzofaj zvmdhsfbjx (ipfrmpojtc ) View more | Negative | 09 Oct 2021 |






