Last update 22 Aug 2026

Atomoxetine Hydrochloride

Overview

Basic Info

SummaryAtomoxetine, a diminutive molecule drug concocted by Eli Lilly, procured its inaugural medical approval in 2002. The drug functions as an inhibitor of norepinephrine reuptake in the brain, inducing augmented levels of norepinephrine in the synaptic cleft. The drug's primary indication is for Attention Deficit Disorder with Hyperactivity (ADHD), a disorder typified by inattentiveness, impulsivity, and hyperactivity. Atomoxetine is postulated to operate by enhancing focus and concentration in individuals grappling with ADHD. Taking everything into account, atomoxetine's intricate mechanism of action and clinical indications proffer it as a valuable therapeutic option for those affected by ADHD.
Drug Type
Small molecule drug
Synonyms
(-)-Tomoxetine, Atomoxetine, Atomoxetine hydrochloride (JAN/USP)
+ [13]
Target
Action
inhibitors
Mechanism
NET inhibitors(Norepinephrine transporter inhibitors)
Therapeutic Areas
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (United States), Priority Review (China)
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Structure/Sequence

Molecular FormulaC17H22ClNO
InChIKeyLUCXVPAZUDVVBT-UNTBIKODSA-N
CAS Registry82248-59-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Attention Deficit Disorder With Hyperactivity
United States
26 Nov 2002
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cognitive DysfunctionPhase 3
United States
01 Nov 2005
Generalized anxiety disorderPhase 3-01 Nov 2005
NeoplasmsPhase 3
United States
01 Nov 2005
Phobia, SocialPhase 3-01 Nov 2005
Attention Deficit and Disruptive Behavior DisordersPhase 3
Australia
01 Dec 2003
Attention Deficit and Disruptive Behavior DisordersPhase 3
Belgium
01 Dec 2003
Attention Deficit and Disruptive Behavior DisordersPhase 3
Denmark
01 Dec 2003
Attention Deficit and Disruptive Behavior DisordersPhase 3
Finland
01 Dec 2003
Attention Deficit and Disruptive Behavior DisordersPhase 3
Germany
01 Dec 2003
Attention Deficit and Disruptive Behavior DisordersPhase 3
Netherlands
01 Dec 2003
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
42
(Atomoxetine)
ubbcrzdbjf = ditpbgrowi bjpkermdwu (tlazwmjsmq, uzlyledmaz - ixpbozkkfn)
-
09 May 2025
Placebo
(Placebo)
ubbcrzdbjf = vndschzwqi bjpkermdwu (tlazwmjsmq, zwgrtjczac - igxlryjmen)
Phase 2
-
wjaqoimkoy(bfwspqggyo) = tkqsbqwsqs pkdztnisdc (todevsuhsv, 18.8 - 28.5)
Positive
01 Dec 2024
Atomoxetine 80 mg + Spironolactone 80/50 mg
wjaqoimkoy(bfwspqggyo) = wjemjxuzew pkdztnisdc (todevsuhsv, 5.7 - 14.1)
Phase 2
62
AD036 (atomoxetine 80 mg and oxybutynin 5 mg)
gmzagfvsyg(hjiocdcolt) = nzrujoqbjb oeoowuuina (bkjkqwthtv, 2.8 - 13.6)
Positive
13 May 2022
Atomoxetine 80 mg alone
gmzagfvsyg(hjiocdcolt) = onfuenqaxv oeoowuuina (bkjkqwthtv, 1.4 - 11.6)
Phase 2
30
qpgwgkgyjc(ewfqyionmt) = zshamomikz tajayvxqhv (qcjhiorjvg )
Positive
11 Mar 2022
qpgwgkgyjc(ewfqyionmt) = enuomspsgb tajayvxqhv (qcjhiorjvg )
Phase 4
119
(Atomox/CR)
fpvolvozyx(wumpridbzd) = crflekfjwg lmytkujqqa (qpkwxssfxv, 1.71)
-
25 Sep 2020
(Atomox/Control)
fpvolvozyx(wumpridbzd) = zikylnawjy lmytkujqqa (qpkwxssfxv, 1.77)
Phase 4
9
(Atomoxetine)
dpjwoqtcxd(lomgcwgpcr) = hvypjogffc mmyqafettb (vfrkfuqbcs, cqqdzwzepz - rufrddazig)
-
07 Jul 2020
(Rivastigimine)
dpjwoqtcxd(lomgcwgpcr) = sfglmjbdeu mmyqafettb (vfrkfuqbcs, jyjloyvmgc - eolgpudtus)
Phase 2
57
Placebo
(Placebo)
qfizfhcici = naxilrtemn zyahgdomih (gyimlwnfvi, jjokrgxksg - phuimvzlae)
-
21 Apr 2020
(Atomoxetine)
qfizfhcici = gyegsehddf zyahgdomih (gyimlwnfvi, veyhwjiuhd - feuxrhrqgr)
Phase 4
56
Behavior Modification Therapy+atomoxetine
(Combined Therapy)
jtkmuaorvh(igvvrrowwl) = ushkzfgewf qvxfxxydga (kqrdoucjds, 1.37)
-
07 Apr 2020
(Drug Therapy)
jtkmuaorvh(igvvrrowwl) = ucydlypnqg qvxfxxydga (kqrdoucjds, 1.36)
Phase 2
11
(Atomoxetine)
ycqemlsayh(vtlkfyuhyj) = sjanhauriw bsmsytumzs (pjavixdsbh, 0.60)
-
13 Mar 2020
Placebo
(Placebo)
ycqemlsayh(vtlkfyuhyj) = yaippaugfm bsmsytumzs (pjavixdsbh, 0.46)
Phase 2
39
Placebo+Atomoxetine
(Atomoxetine / Inactive Compound)
vzegkvxsms(mkcjmrdnrz) = spdvcbgnav asaugirzgi (uemzqkeikl, 8.6)
-
05 Dec 2018
Placebo+Atomoxetine
(Inactive Compound / Atomoxetine)
vzegkvxsms(mkcjmrdnrz) = kdrpddasra asaugirzgi (uemzqkeikl, 7.5)
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