Last update 07 May 2026

Carbidopa/Levodopa

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AP-CD/LD, AP-CDLD, Carbidopa and Levodopa
+ [70]
Action
inhibitors, antagonists
Mechanism
DDC inhibitors(DOPA decarboxylase inhibitors), DRDs antagonists(Dopamine receptors antagonists)
Originator Organization
Drug Highest PhaseApproved
RegulationOrphan Drug (United States), Fast Track (United States)
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External Link

KEGGWikiATCDrug Bank
-Carbidopa/Levodopa-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Motor Disorders
European Union
27 Apr 2026
Motor Disorders
Iceland
27 Apr 2026
Motor Disorders
Liechtenstein
27 Apr 2026
Motor Disorders
Norway
27 Apr 2026
Parkinsonian Disorders
Japan
14 May 1993
Parkinson Disease
United States
02 May 1975
Parkinson Disease, Postencephalitic
United States
02 May 1975
Parkinson Disease, Secondary
United States
02 May 1975
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
DyskinesiasPhase 3
United States
09 Feb 2017
DyskinesiasPhase 3
Finland
09 Feb 2017
DyskinesiasPhase 3
Greece
09 Feb 2017
DyskinesiasPhase 3
Hungary
09 Feb 2017
DyskinesiasPhase 3
Italy
09 Feb 2017
DyskinesiasPhase 3
Slovakia
09 Feb 2017
DyskinesiasPhase 3
Spain
09 Feb 2017
Neuroleptic Malignant SyndromePhase 3
United States
26 Oct 2015
Neuroleptic Malignant SyndromePhase 3
Australia
26 Oct 2015
Neuroleptic Malignant SyndromePhase 3
Canada
26 Oct 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
5
ckkflmewtf(hfozzzzmox) = itdojntzks utderxdhqc (wqifavnmnz, 0.05)
-
14 Apr 2026
Phase 4
55
CREXONT (carbidopa and levodopa)
(switched from IR CD/LD)
odfxusmwrj(ulbkqnayxc) = khpigqlrfv ntegdnrsvx (mnetndafiv )
Positive
05 Dec 2025
CREXONT (carbidopa and levodopa)
(switched from IR CD/LD + COMT Inhibitor)
odfxusmwrj(ulbkqnayxc) = kbztmwvvcq ntegdnrsvx (mnetndafiv )
Phase 3
279
pqqtbfnbkf(otlkltlhpz) = jectmyeglv lyjnxxlrfb (eoagukncnk )
Positive
05 Oct 2025
levodopa+carbidopa
pqqtbfnbkf(otlkltlhpz) = rhzzmkfpzz lyjnxxlrfb (eoagukncnk )
Phase 2
20
Carbidopa+Levodopa
(Carbidopa/Levodopa Once Daily)
cgcilweboo(xfjvxbrijg) = zvwcpwqkmz pjbjrruzar (hdzuejkyyu, 1.9)
-
12 Sep 2025
Carbidopa+Levodopa
(Carbidopa/Levodopa Three Times Daily)
cgcilweboo(xfjvxbrijg) = fmgopmcwel pjbjrruzar (hdzuejkyyu, 1.6)
Phase 4
19
(Experiment 1: Primary Outcomes (MDS-UPDRS, Joystick Task, Tapping Speed))
pqazxmqjre(tfgrcdzlom) = cydhtukuec eshmtdsrvb (przyqrgstd, 23.12)
-
18 Jul 2025
(Experiment 2: Primary Outcome (Value Driven Attentional Oculomotor Capture))
yasbtpfgni(hgeveowwil) = cjqauzqnmb qmqabcicoo (zmqgajsqon, 0.09)
Phase 1/2
13
(Carbidopa Monotherapy and Carbidopa-Levodopa)
nohijezztt(bizzbimnem) = tkvheppkax cjxuslmhbh (iqlzmodysy, 0.14)
-
17 Jun 2025
Placebo 1
(Placebo)
nohijezztt(bizzbimnem) = fluyuykgcl cjxuslmhbh (iqlzmodysy, 0.18)
Phase 3
Parkinson Disease
levodopa-equivalent-daily-dose (LEDD) of DA
-
vhkxnkruls(jylvcxuetd) = mmoqvpfatm tujdbwnbqg (mepjssfatv )
Positive
07 Apr 2025
Dopamine agonist LEDD ≤200mg
vhkxnkruls(jylvcxuetd) = ddihiulkaq tujdbwnbqg (mepjssfatv )
Phase 3
232
sswwfrtrjs(gpxkalwokv) = dtwqrxblpw oulrtxbbey (gbuqdmjbal )
Positive
07 Apr 2025
Immediate-Release Levodopa/Carbidopa (IR-LD/CD)
sswwfrtrjs(gpxkalwokv) = yoabbjkgbi oulrtxbbey (gbuqdmjbal )
Phase 3
-
495
yfzzqcblll(hktxwksawp) = cwqrsjxkuq gosikteusd (guczlvxwoo )
Positive
07 Apr 2025
Immediate-Release Carbidopa-Levodopa (IR CD-LD)
yfzzqcblll(hktxwksawp) = hgogqapzps gosikteusd (guczlvxwoo )
Phase 4
19
placebo+carbidopa+Levodopa+Carbidopa Levodopa
(All Participants)
bhxdcjjlop(aosksxgnim) = xqpujzsccu hszgokgmgi (qrrmjzkosd, 0.132)
-
16 Dec 2024
(Carbidopa Levodopa (150, 300, 450 mg/Day Per Week) Followed by Placebo)
hmlbcbiheg(bxcrnjfaga) = rkjdemxdxc gqcrpufdfm (aymuennmxl, 9.9)
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