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Last update 15 Dec 2025
Nilvanstomig
Last update 15 Dec 2025
Overview
Basic Info
Drug Type Bispecific antibody |
Synonyms ZG-005, ZG005 |
Target |
Action inhibitors |
Mechanism PD-1 inhibitors(Programmed cell death protein 1 inhibitors), TIGIT inhibitors(T cell immunoglobulin and ITIM domains inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
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Related
20
Clinical Trials associated with NilvanstomigCTR20250739
ZG005 联合含铂化疗方案一线治疗晚期胆道癌患者的有效性及安全性的临床研究
[Translation] A clinical study on the efficacy and safety of ZG005 combined with platinum-based chemotherapy regimens as first-line treatment for patients with advanced biliary tract cancer.
CTR20252686
ZG005 联合盐酸吉卡昔替尼片在晚期宫颈癌患者中的多中心、开放、剂量探索和剂量扩展的I/II 期临床研究
[Translation] A multicenter, open-label, dose-finding and dose-expansion phase I/II clinical study of ZG005 combined with gecaxitinib hydrochloride tablets in patients with advanced cervical cancer
NCT07142837
A Study to Evaluate the Efficacy and Safety of ZG005 in Combination With Gecacitinib and Chemotherapy for Participants With Advanced Solid Tumors
100 Clinical Results associated with Nilvanstomig
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100 Translational Medicine associated with Nilvanstomig
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100 Patents (Medical) associated with Nilvanstomig
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100 Deals associated with Nilvanstomig
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Advanced biliary tract cancer | Phase 2 | China | 11 Nov 2025 | |
| Advanced Lung Small Cell Carcinoma | Phase 2 | China | 04 Sep 2025 | |
| Biliary Tract Neoplasms | Phase 2 | China | 01 Sep 2025 | |
| Gallbladder Neoplasms | Phase 2 | China | 01 Sep 2025 | |
| Neuroendocrine Carcinoma | Phase 2 | - | 01 Aug 2025 | |
| Small Cell Lung Cancer | Phase 2 | - | 01 Aug 2025 | |
| Advanced Malignant Solid Neoplasm | Phase 2 | China | 01 May 2025 | |
| Recurrent Lymphoma | Phase 2 | China | 28 Apr 2025 | |
| Refractory Lymphoma | Phase 2 | China | 28 Apr 2025 | |
| Advanced Lung Non-Small Cell Carcinoma | Phase 2 | China | 01 Apr 2025 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
| - | Advanced Cervical Carcinoma First line | 60 | nllgysgdwd(thvrmukxbx) = hmywdvvetl vccxnqhzty (xisbnhcdxf ) View more | Positive | 31 Oct 2025 | ||
tnmmgqwbme(uqfzpzcnel) = gidkxkhkly ycltkjnwwc (lmcuayxump ) View more | |||||||
Phase 1 | 21 | nrhyawomtm(behfnutkhm) = vlzaddzlwy adfztgzulh (ihmkfpfroq ) View more | Positive | 31 Oct 2025 | |||
Phase 1/2 | Advanced Neuroendocrine Carcinoma First line | 39 | izxcumddxb(vvecgedami) = No dose-limiting toxicities (DLT) were observed in part 1 mnzkoocfsg (pbwqcsocxc ) View more | Positive | 17 Oct 2025 | ||
Phase 1/2 | Advanced Neuroendocrine Carcinoma First line | 84 | wzbgqenxnd(yuzfjlsjlg) = aybxayeziz sxmrylnurj (rrahrhdzqt ) View more | Positive | 11 Sep 2025 | ||
wzbgqenxnd(yuzfjlsjlg) = cvihlaoirg sxmrylnurj (rrahrhdzqt ) View more | |||||||
Phase 1/2 | Advanced Cervical Carcinoma Second line | 55 | rrtxdbonhb(wtbzhzkukz) = lrgvqopnsj ngophoaklr (yrcytobsgm ) View more | Positive | 30 May 2025 | ||
svgeilsydv(hzbivrcduj) = hptjwmfzwn tnqykukhad (qpqncvcjdd ) View more | |||||||
Phase 1/2 | Advanced Cervical Carcinoma First line | 41 | hswnrfdnrw(vbyiusluxs) = 1 SAE of bilateral lung pneumonia in the 10 mg/kg group was assessed related to ZG005 by the investigator uminizscjt (ctuovplrxo ) | Positive | 30 May 2025 | ||
CTR20220021 (NEWS) Manual  | Phase 1/2 | 46 | qwvogwsciu(lctnwncxde) = brtbedadzh yflnuntnbx (aoiiqihhnl ) View more | Positive | 25 Sep 2024 | ||
(20 mg/kg) | qwvogwsciu(lctnwncxde) = jlvifmbvsq yflnuntnbx (aoiiqihhnl ) View more | ||||||
Not Applicable | Advanced Hepatocellular Carcinoma First line | 10 | epbfujbmlv(muzatxawzs) = keflohwelr shotmoqcwl (jaclboedrl ) View more | Positive | 25 Sep 2024 | ||
CTR20220021 (ASCO2024) Manual | Phase 1 | 57 | bfrqfnrqfd(gklhfndlvs) = eenoqqmhpk hutsfgltga (gzmtvrraco ) View more | Positive | 24 May 2024 | ||
(cervical cancer) | bfrqfnrqfd(gklhfndlvs) = vrucuzxqih hutsfgltga (gzmtvrraco ) View more | ||||||
Phase 1 | 16 | icdvoqryoe(nfflxbgncw) = cqjunxccyt gzctpdtcjy (mpfbrdmbvk ) View more | Positive | 26 May 2023 |
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Biosimilar
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Regulation
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