Albiglutide

Preclinical studies demonstrate measurable systemic semaglutide exposure following oral administration; granted claims cover semaglutide and multiple GLP-1 receptor agonists. PARIS--(BUSINESS WIRE)-- BioLife today announced that the United States Patent and Trademark Office has granted U.S. Patent 12,667,605 B2 for its novel effervescent oral peptide delivery technology, designed to support current and future peptide therapeutics for obesity, diabetes and metabolic disease. The announcement comes as demand for GLP-1 medicines continues to accelerate. GLP-1 therapies generated approximately $132 billion in global sales in 2025, while obesity medicines now represent an estimated $42 billion market. 1 As more patients seek alternatives to injections, demand for alternative oral treatments continues to grow. First generation oral GLP-1 medicines have demonstrated the value of oral administration while also underscoring on the fundamental challenges in peptide drug development: protecting large peptide molecules as they move through the gastrointestinal tract. BioLife’s unique technology was developed to explore what comes next. Built on more than 35 years of pharmaceutical effervescence expertise, this novel approach to oral peptide delivery uses a dissolvable effervescent tablet format that creates a first-of-its-kind gastric buffer designed to help protect peptide therapeutics through the digestive system and support their absorption. "GLP-1 medicines have changed how obesity and metabolic disease are treated, but we still need better oral options," said Dr. Farid Bennis, Founder of BioLife and inventor of the technology known internally as OralMatrix. "This patent represents much more than protection for a formulation. It reflects decades of scientific work focused on addressing on the most important challenges in peptide medicine: helping these molecules pass through the digestive system intact, for today’s therapies and for future generations of peptide therapeutics." The technology takes a different approach to oral peptide drug delivery. Rather than relying on special coatings or absorption-enhancing ingredients, it uses a dissolvable effervescent format designed to help protect peptide medicines as they move through the digestive system. Preclinical studies have demonstrated measurable systemic semaglutide exposure following oral administration, providing in vivo proof of concept for the approach. The granted U.S. claims extend across the GLP-1 class, including semaglutide, liraglutide, dulaglutide, albiglutide, exenatide and lixisenatide. Patent protection runs into 2042 with additional patent applications pending internationally. Oral peptide drug delivery remains an important area of innovation as pharmaceutical companies evaluate increasingly sophisticated therapies for obesity, diabetes and metabolic disease. The opportunity extends beyond today's GLP-1 medicines and toward future generations of peptide therapeutics. About the Technology BioLife’s patented effervescent peptide delivery technology uses a dissolvable tablet format designed to support oral delivery of peptide medicines, including GLP-1 therapies. Preclinical studies have demonstrated measurable systemic semaglutide exposure following oral administration. The development programme builds on nearly 20 years of research, including human clinical studies with oral insulin formulations and collaborations with Charles River Laboratories, SGS, Eurofins/Amatsi and Cephac. The technology is in development and is not approved for the treatment of any disease. About Dr. Farid Bennis Dr. Farid Bennis, eminent expert in effervescence research and technology is the founder of BioLife, named inventor on U.S. Patent No. 12,667,605 B2, and Chairman of the pharmaceutical company Laprophan Group, established in 1949 and present in more than 40 countries. Over more than 35 years, Dr Bennis has developed pharmaceutical effervescence technologies across multiple therapeutic areas, resulting in numerous patented inventions and commercialized healthcare products. The technology reflects nearly two decades of work devoted to oral peptide delivery. About BioLife BioLife develops oral delivery technologies for peptide medicines, combining expertise in pharmaceutical effervescence, formulation science and oral peptide research. The company's technology portfolio and related patent estate have been independently developed and are wholly owned. Sources 1 Managed Healthcare Executive, "GLP-1 Drugs to Drive Growth in Obesity and Diabetes Treatment," reporting IQVIA market data presented at AMCP Annual 2026. Available at: Contacts Media & Partner Enquiries US: Peter Opitz 608-712-9614 Europe: Misha Talheth-Fells +447548907984 Business & Licensing: Paul Sagan 617-852-0495 LaVoie Strategic Communications Group, Inc. biolife@lavoiegroup.com

Drugs also related to lower use of drugs to stop, prevent attacks Highlights: For people with chronic migraine, starting GLP-1 drugs for conditions like diabetes may be associated with fewer emergency department visits. A preliminary study has found that people who started GLP-1 drugs were approximately 10% less likely than those who started topiramate to visit the emergency department over the following year. They were also about 14% less likely to be hospitalized for any reason during the year. This observational study does not prove that the drugs lower the need for emergency care for people with migraine. It only shows an association. MINNEAPOLIS, March 2, 2026 /PRNewswire/ -- For people with chronic migraine, taking glucagon-like peptide-1 receptor agonists, or GLP-1 drugs, for other conditions such as diabetes and weight loss, was associated with fewer emergency department visits and hospitalizations overall, and with less need for medications used to stop and prevent migraine attacks, according to a preliminary study released March 1, 2026, that will be presented at the American Academy of Neurology's 78th Annual Meeting taking place April 18-22, 2026, in Chicago and online. The people with chronic migraine starting GLP-1 drugs were compared to people with chronic migraine who were starting topiramate, a drug commonly used to prevent migraine. The study does not prove that GLP-1 drugs lower the need for emergency care and additional drugs for migraine; it only shows an association. "People with chronic migraine often end up in the emergency room or they need to try several preventive medications before finding one that can work for them," said study author Vitoria Acar, MD, of the University of Sao Paulo in Brazil. "Seeing these patterns of lower use of emergency care and lower use of drugs to stop migraines or trying additional drugs to prevent migraines among people taking GLP-1 drugs for other conditions suggests that these therapies may help stabilize the disease burden in ways that we haven't fully appreciated yet. " For the study, researchers analyzed a health-record database of people who had a chronic migraine diagnosis based on medical records. Chronic migraine is defined by having a headache on 15 or more days per month for at least three months, where at least eight of those days include typical migraine symptoms like throbbing pain, nausea, or light sensitivity. People who had started taking GLP-1 drugs for another condition within a year of a recorded diagnosis of chronic migraine were compared to people who started taking topiramate during that same period. The two groups were matched for factors such as age, body mass index, other health conditions, and prior migraine treatments. There were about 11,000 people in each group. The GLP-1 drugs studied included liraglutide, semaglutide, dulaglutide, exenatide, lixisenatide and albiglutide. The researchers used medical records to track what happened to both groups over the following year. This included overall emergency department visits, hospitalizations, nerve block procedures, and any new prescriptions for medications used to stop or prevent migraine attacks. After accounting for differences in age, body weight, other health conditions, and prior migraine treatments, researchers found that 23.7% of people starting GLP-1 drugs visited the emergency department over the following year, compared with 26.4% of those starting topiramate. People starting GLP-1 drugs were about 10% less likely to have an emergency department visit, 14% less likely to be hospitalized, and about 13% less likely to undergo a nerve block procedure or receive a triptan prescription compared with those taking topiramate. They were also less likely to be prescribed new preventive migraine medications. Compared with people starting topiramate, those starting GLP-1 drugs were 48% less likely to start valproate, 42% less likely to start calcitonin gene-related peptide (CGRP) monoclonal antibodies, 35% less likely to start tricyclic antidepressants, and 23% less likely to start the class of drugs called gepants. There was no statistically significant difference between the two groups in the proportion of people starting beta blockers. "Chronic migraine often overlaps with metabolic and inflammatory conditions such as obesity, insulin resistance, sleep apnea and depression, which can make treatment more difficult," Acar said. "Early research is looking at whether GLP-1 drugs' anti-inflammatory and neurovascular effects could play a role in migraine treatment, not just through weight loss." Because this was an observational study, it cannot prove that GLP-1 drugs caused the lower need for emergency care or additional medications. Even though the groups were matched at the start, researchers could not measure things that changed over the year, such as weight loss, migraine severity, medication use patterns or lifestyle changes. These unmeasured factors could also have played a role. Further studies are needed. The study was supported by patient philanthropy and Miles for Migraine. Discover more about migraine at Brain & Life®, from the American Academy of Neurology. This resource also offers a website, podcast, and books that connect patients, caregivers and anyone interested in brain health with the most trusted information, straight from the world's leading experts in brain health. Follow Brain & Life® on Facebook, X, and Instagram. The American Academy of Neurology is the leading voice in brain health. As the world's largest association of neurologists and neuroscience professionals with more than 44,000 members, the AAN provides access to the latest news, science and research affecting neurology for patients, caregivers, physicians and professionals alike. The AAN's mission is to enhance member career fulfillment and promote brain health for all. A neurologist is a doctor who specializes in the diagnosis, care and treatment of brain, spinal cord and nervous system diseases such as Alzheimer's disease, stroke, concussion, epilepsy, Parkinson's disease, multiple sclerosis, headache and migraine. Explore the latest in neurological disease and brain health, from the minds at the AAN at AAN.com or find us on Facebook, X, Instagram, LinkedIn, and YouTube. SOURCE American Academy of Neurology 21% more press release views with Request a Demo