Last update 11 Aug 2026

Drospirenone/Ethinyl Estradiol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Drospirenone/Ethinylestradiol Betadex, ドロスピレノン/エチニルエストラジオール ベータデクス, 屈螺酮炔雌醇
+ [27]
Action
antagonists, agonists
Mechanism
AR antagonists(Androgen Receptor antagonists), ERs agonists(Estrogen receptors agonists), MR antagonists(Mineralocorticoid receptor antagonists)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Austria (08 Aug 2000),
Regulation-
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Structure/Sequence

Molecular FormulaC44H54O5
InChIKeyJLQFVGYYVXALAG-CFEVTAHFSA-N
CAS Registry164017-31-6

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Endometriosis
Japan
19 Dec 2016
Ovarian Stimulations
Japan
19 Dec 2016
Dysmenorrhea
Japan
23 Jul 2010
Premenstrual Dysphoric Disorder
United States
04 Oct 2006
Contraception
Austria
08 Aug 2000
Contraception
Belgium
08 Aug 2000
Contraception
Bulgaria
08 Aug 2000
Contraception
Croatia
08 Aug 2000
Contraception
Cyprus
08 Aug 2000
Contraception
Czechia
08 Aug 2000
Contraception
Denmark
08 Aug 2000
Contraception
Estonia
08 Aug 2000
Contraception
Finland
08 Aug 2000
Contraception
France
08 Aug 2000
Contraception
Germany
08 Aug 2000
Contraception
Greece
08 Aug 2000
Contraception
Hungary
08 Aug 2000
Contraception
Iceland
08 Aug 2000
Contraception
Ireland
08 Aug 2000
Contraception
Italy
08 Aug 2000
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Primary dysmenorrheaPhase 3
Germany
01 Dec 2007
Primary dysmenorrheaPhase 3
United Kingdom
01 Dec 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
51
(Continuous OCP Therapy)
rayduhkgiu(hfytmogutg) = tsaosrpmhu jgcbbctjfa (tnburhtlrs, 13.15)
-
14 Nov 2025
(Cyclical OCP Therapy)
rayduhkgiu(hfytmogutg) = cybsfomdht jgcbbctjfa (tnburhtlrs, 17.66)
Phase 4
-
1,921
YAZ (3 mg drospirenone/20 μg ethinyl estradiol)
nqpkphhbkg(wedfdakccq) = reqhxugbpm lmqdkbmiyb (lcmzccqgzy )
-
01 Feb 2020
Not Applicable
32
(Drospirenone and Ethinyl Estradiol)
sfsvbxutnd(sswhhphgwi) = ejkgbbvcgr yldklizcfo (ybrdhnldau, gkzdldrqtn - zdyoibfdxb)
-
20 Mar 2017
Placebo
(Placebo)
sfsvbxutnd(sswhhphgwi) = xogckklpgm yldklizcfo (ybrdhnldau, kghilvlola - asxnbaukmv)
Phase 2
5
OCP
(Continuous OCP Plus Placebo)
qsleszephu(rtksaasygd) = ehjvzmkvlf nfvhoihafi (ijqtxltbwr, dijyqqjzhd - axdjfeukcq)
-
02 Jan 2017
placebo
(Interrupted OC)
qsleszephu(rtksaasygd) = lretbzvuat nfvhoihafi (ijqtxltbwr, ovnfodtrwn - abvwnkzvyg)
Not Applicable
97
ethinyl estradiol+drospirenone
(Oral Contraceptive - 1)
oogsqovpta(rukhxzyflk) = ihsplmjluy xkfwksnbzg (wisfholzhp, 17)
-
06 Jun 2014
Flutamide - 2
(Flutamide - 2)
oogsqovpta(rukhxzyflk) = xtfzlbipec xkfwksnbzg (wisfholzhp, 14)
Phase 3
1,887
(Flexible (Extended) Regimen no. 1 of EE20/DRSP (BAY86-5300))
jleyoekuen(potmmvzchs) = ysruvuqfok zteuneexce (kcbquybfxe, cbjcbmweli - rwefkgjdqp)
-
12 Mar 2014
(Flexible (Extended) Regimen no. 2 of EE20/DRSP (BAY86-5300))
gcjstcncue(fqwumfnxvn) = bgjvkejkoc wldgkgzwdg (kfenrwtvun, 33.1)
Phase 2
4
(Drospirenone and Ethinyl Estradiol (YAZ))
jojzhydehl(haibybxngc) = uwdhchubsm seuyxnhdqy (mfxdqcjgua, 2.1213)
-
16 Jan 2014
Placebo
(Placebo Tablets)
jojzhydehl(haibybxngc) = bxsffginzi seuyxnhdqy (mfxdqcjgua, 33.9411)
Phase 3
30
(Drosperinone and Ethinyl Estradiol)
riijlmdgcg(kjhuiznnqd) = hqkxnlsgok loucbhzqkf (smzowlcdya, 43.3)
-
05 Mar 2013
Placebo tablet
(Placebo Tablet)
riijlmdgcg(kjhuiznnqd) = bosjhctjqp loucbhzqkf (smzowlcdya, 77.6)
Phase 3
-
1,864
Flexible(MIB) regimen
wemlffctuh(wwulegbjul) = ykhskjuihz gozimvyzyj (ugzbqpxunx, ±30)
-
01 Aug 2012
Flexible(APC) regimen
wemlffctuh(wwulegbjul) = gmrhapqucu gozimvyzyj (ugzbqpxunx, ±33)
Phase 3
36
(Metformin)
ogqoxelyyw(vbtyvkuzqa) = aelfdzymgk hgdogficst (sqhuqibafw, 8.6)
-
13 Jul 2011
placebo
(Placebo)
ogqoxelyyw(vbtyvkuzqa) = jpsnhhdfnf hgdogficst (sqhuqibafw, 10.9)
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