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Last update 16 Jun 2025
Olopatadine Hydrochloride
Last update 16 Jun 2025
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms Allelock OD, olopatadine, Olopatadine hydrochloride (JP17/USP) + [19] |
Target |
Action antagonists |
Mechanism H1 receptor antagonists(Histamine H1 receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (18 Dec 1996), |
Regulation- |
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Structure/Sequence
Molecular FormulaC21H24ClNO3 |
InChIKeyHVRLZEKDTUEKQH-NOILCQHBSA-N |
CAS Registry140462-76-6 |
Related
85
Clinical Trials associated with Olopatadine HydrochlorideCTRI/2025/04/085610
Randomized Controlled Clinical Trial on Comparison of Yastimadhu Arka Eye Drop with Olopatadine 0.1% Eye Drop in Vataj Abhishyanda (Simple Allergic Conjunctivitis)
CTR20250961
盐酸奥洛他定颗粒在空腹条件下的人体生物等效性试验
[Translation] Bioequivalence study of olopatadine hydrochloride granules in humans under fasting conditions
CTR20250907
盐酸奥洛他定片在中国成年健康受试者中的一项随机、开放、空腹和餐后单次给药、两制剂、两序列、两周期交叉的生物等效性试验
[Translation] A randomized, open-label, single-dose, fasting and fed, two-formulation, two-sequence, two-period crossover bioequivalence study of olopatadine hydrochloride tablets in healthy adult Chinese subjects
100 Clinical Results associated with Olopatadine Hydrochloride
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100 Translational Medicine associated with Olopatadine Hydrochloride
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100 Patents (Medical) associated with Olopatadine Hydrochloride
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725
Literatures (Medical) associated with Olopatadine Hydrochloride01 Jul 2025Ocular Surface
Ranking the efficacy of topical treatments for ocular allergy: A network meta-analysis of current evidence
Review
Author: Krungkraipetch, Dechathorn ; Tansavadi, Taweelarp ; Krungkraipetch, Luksanaporn
PURPOSE:
To evaluate and rank the comparative effectiveness of topical treatments for different types of ocular allergies through a systematic review and network meta-analysis.
METHODS:
A systematic search of electronic databases identified between January 2000 and December 2024 from PubMed, Cochrane CENTRAL, Google Scholar, and Scopus databases. Study Selection; randomized controlled trials assessing topical treatments for ocular allergy, including antihistamines, corticosteroids, immunomodulators, and combination therapies. Data Extraction and Synthesis; data were independently extracted and analyzed following PRISMA guidelines. Direct and indirect comparisons were evaluated using network meta-analysis, and SUCRA rankings assessed relative efficacy. Main Outcomes and Measures; reduction in ocular itching, redness, and inflammation. PROSPERO Registration number: CRD42025634572.
RESULTS:
Olopatadine 0.1 % demonstrated highest efficacy in seasonal and perennial allergic conjunctivitis (SUCRA 0.88 and 0.85, respectively), while Tacrolimus 0.1 % showed superior effectiveness in vernal and atopic keratoconjunctivitis (SUCRA 0.92 and 0.89, respectively). Overall treatment effect was significant (OR = 6.95, 95 % CI: 6.24-7.75) with moderate heterogeneity (I2 = 50.8 %). Subgroup analysis revealed consistent efficacy across different types of allergic conjunctivitis, with seasonal allergic conjunctivitis showing the highest cumulative ranking probability (89.0 %).
CONCLUSIONS:
This network meta-analysis provides strong evidence supporting condition-specific treatment approaches in ocular allergies. Newer antihistamines, particularly Olopatadine, are most effective for mild-moderate conditions, while immunomodulators, especially Tacrolimus, show superior efficacy in severe cases. These findings provide clear evidence-based hierarchies for clinical decision-making in the management of different types of allergic conjunctivitis.
01 Sep 2025EUROPEAN JOURNAL OF PHARMACOLOGY
Drug-related visual blurring: findings from the U.S. Food and Drug Administration Adverse Event Reporting System database
Article
Author: Chen, Lin ; Liu, Zuguo ; Wu, Shi-Nan ; Hu, Jiaoyue ; Sun, Le ; Guan, Wen-Ying ; Huang, Caihong ; Chen, Xiao-Dong ; Liu, Qian-Ting ; Kang, Jia-Yu
BACKGROUND:
Visual blurring is one of the most common symptoms in ophthalmology, and one of the important causes of secondary visual blurring is drug-related. This study assesses the risk of drug-related visual blurring using a large real-world database.
METHODS:
We analyzed adverse event reports from the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) database between January 2004 and September 2024. Disproportionality analysis algorithm were used. Drugs related with positive signals for visual blurring were categorized, and the risk levels, number of reports, and drug-induced onset times were quantified.
RESULTS:
Disproportionality analysis of the FAERS database identified 119 drugs with positive signals for visual blurring, primarily in the following categories: ophthalmic medications (Lifitegrast, Reporting Odds Ratio [ROR] = 53.24; 95 % Confidence Interval [CI]: 49.19-57.61), endocrine medications (Semaglutide, ROR = 3.26 [2.84-3.75]), nervous system medications (Pregabalin, ROR = 4.15 [3.93-4.37]), oncology medications (Encorafenib, ROR = 5.38 [4.37-6.62]), antimuscarinic medications (Fesoterodine, ROR = 6.77 [5.08-9.03]), and other medications (Dupilumab, ROR = 8.39 [8.16-8.64]). The top three drugs associated with the highest incidence of blurred vision as an adverse event are lifitegrast, oxymetazoline, and olopatadine. Antimuscarinic Medications had the shortest drug-induced onset time. Women (63.87 %) and middle-aged to elderly individuals [Age (mean ± standard deviation): 53.59 ± 18.79] were the main populations affected by drug-related visual blurring.
CONCLUSION:
Preventing drug-related vision issues is vital. Early risk assessment and intervention with personalized medication can reduce side effects, ensure safety, and improve quality of life.
01 Apr 2025INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Association between congenital Zika syndrome and hospitalizations during early childhood: a nationwide cohort study
Article
Author: Teixeira, Maria Gloria ; Paixão, Enny S ; Barreto, Mauricio L ; Tedde, João Guilherme G ; Costa, Maria da Conceição ; Silva, Thiago Cerqueira ; Cardim, Luciana ; Rodrigues, Laura ; Brickley, Elizabeth B
OBJECTIVES:
Congenital Zika Syndrome (CZS) has been linked to a wide spectrum of abnormalities. However, differences in hospitalization patterns between children with and without CZS have not yet been investigated.
METHODS:
We compared rates of hospital admissions for all and specific diseases, proportions of admission causes, and total length of hospital stay (LOS) between children with CZS and those without the syndrome. Adjusted incidence rate ratios (aIRR) and aLOS were estimated using negative binomial regression.
RESULTS:
Compared to those without CZS, the aIRR for all-cause hospitalizations in the CZS group ranged from 3.77 (95%CI: 3.47-4.06) in the neonatal period to 7.76 (95%CI: 6.91-8.61) at ages 2-4 years. Similar trends were observed for specific causes of admissions. Most admissions in the CZS group related to congenital malformations, neurological, respiratory and infectious diseases. aLOS ranged from 16.0 days [95%CI: 13.2-19.5] to 19.9 days among CZS patients and 6.0 days [95%CI: 5.9-6.2] to 9.3 days [95%CI: 9.3-9.4] for patients without the syndrome.
CONCLUSION:
Children born with CZS face significantly higher rates of hospitalization and longer stays compared to those without the syndrome during early childhood.
22
News (Medical) associated with Olopatadine Hydrochloride
100 Deals associated with Olopatadine Hydrochloride
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External Link
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D01192 | Olopatadine Hydrochloride |
R&D Status
Approved
10 top approved records. to view more data
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| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Rhinitis, Allergic, Seasonal | United States | 15 Apr 2008 | |
| Allergic rhinoconjunctivitis | Japan | 26 Jul 2006 | |
| Seasonal allergic conjunctivitis | European Union | 16 May 2002 | |
| Seasonal allergic conjunctivitis | Australia | 16 May 2002 | |
| Seasonal allergic conjunctivitis | Iceland | 16 May 2002 | |
| Seasonal allergic conjunctivitis | Liechtenstein | 16 May 2002 | |
| Seasonal allergic conjunctivitis | Norway | 16 May 2002 | |
| Pruritus | Japan | 22 Dec 2000 | |
| Rhinitis, Allergic | Japan | 22 Dec 2000 | |
| Urticaria | Japan | 22 Dec 2000 | |
| Conjunctivitis, Allergic | United States | 18 Dec 1996 |
Developing
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Perennial allergic conjunctivitis | Phase 3 | - | 01 Jan 2012 | |
| Acute conjunctivitis | Phase 3 | - | 01 Oct 2009 | |
| Rhinitis, Allergic, Perennial | Phase 3 | United States | 01 Dec 2006 | |
| Rhinoconjunctivitis | Phase 3 | - | 18 Apr 2006 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Not Applicable | 96 | fhtulrxkrp(qfnbwidprx) = vwkbftslgj sxxspeqnly (nhaugemxzz ) | Positive | 06 Mar 2019 | |||
Sodium Cromoglycate 2% | fhtulrxkrp(qfnbwidprx) = agfdqyqhmx sxxspeqnly (nhaugemxzz ) | ||||||
Not Applicable | - | GSP301 (olopatadine 665μg/mometasone 25μg BID) | gozfoaucaw(efzikdkvvg) = ffpbcifaes hxrqylmhxu (gjtbjncazi, -0.41 to -0.05) | - | 01 Feb 2019 | ||
Not Applicable | 21 | iihrbbujtn(izoxffttqe) = vmbyxzsygr lnivvlwqfc (bdfygswkeh, ogrwjfbmyc - lzqbfdtana) View more | - | 20 Sep 2018 | |||
Not Applicable | 180 | GSP301 BID | arzhrdmfet(dqlflzcnfh) = GSP301 BID had a rapid onset of action of 10 minutes and provided significant improvements in ocular symptoms vs placebo yopqusvjet (damekmnzoi ) | Positive | 01 Feb 2018 | ||
Not Applicable | - | GSP301 (olopatadine 665μg/mometasone 25μg BID) | asuhbswsee(whtsriruxq) = rjwkekbobf togbuzrfhc (zmnqqbvbdg, -0.35[-0.63 - -0.07]) | - | 01 Feb 2018 | ||
Phase 3 | - | 448 | Olopatadine 0.77% | olnmwsfbvf(vtvbfmteab) = vcwvehfxqb odfjadpnir (jlzqtnbces ) | Positive | 01 Jun 2015 | |
Olopatadine 0.1% | olnmwsfbvf(vtvbfmteab) = hzfdzknzag odfjadpnir (jlzqtnbces ) | ||||||
Phase 4 | 17 | (Left Eye) | hchtkitqpp(adjtmvazos) = utvmlvdsbl urzjwavbtk (dggjaehqen, 0.85) View more | - | 18 Aug 2014 | ||
(Right Eye) | hchtkitqpp(adjtmvazos) = rdrgptopbg urzjwavbtk (dggjaehqen, 0.92) View more | ||||||
Phase 3 | 902 | (AL-4943A) | thapsaxnuf(ynogauqlqw) = laoyhskhcg yyqrplvavg (wcwkfnbsov, 0.069) View more | - | 11 Aug 2014 | ||
thapsaxnuf(ynogauqlqw) = mwjmqjlvgs yyqrplvavg (wcwkfnbsov, 0.069) View more | |||||||
Phase 3 | 518 | (AL-4943A) | oyvxqimyjn = xejpgiaigx uhrlmkwpqe (akcoggnpdg, kyldzxscrr - zwiwrwlktw) View more | - | 28 Feb 2014 | ||
(AL-4943A Vehicle) | oyvxqimyjn = wtenmkeoil uhrlmkwpqe (akcoggnpdg, fjstmfcqff - tzuwvaxweg) View more | ||||||
Phase 4 | 157 | (Lastacaft®) | whdwrvlctj(zvivqfygcs) = katqluvnze oiobbzcouq (ztlfpsmpeh, 0.582) View more | - | 14 Jan 2014 | ||
(Pataday™) | whdwrvlctj(zvivqfygcs) = kfbrshhfmm oiobbzcouq (ztlfpsmpeh, 0.752) View more |
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