Delving into the Latest Updates on Matricaria chamomilla extract with Synapse

Overview

Basic Info

Drug Type

Herbal medicine

Synonyms

chamomile extract

Target

Nrf2

Action

stimulants

Mechanism

Nrf2 stimulants(Nuclear factor erythroid 2-related factor 2 stimulants)

Therapeutic Areas

Other Diseases

Active Indication

stress oxidative

Inactive Indication

Generalized anxiety disorder

Originator Organization

University of Pennsylvania

Active Organization

Case Western Reserve University

Inactive Organization

University of Pennsylvania

License Organization-

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

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After impacted wisdom tooth extraction, patients frequently complain of pain, edema, and limited mouth opening. After the procedure, patients are routinely recommended to use chlorhexidine and physiological serum-based mouthwashes. The antibacterial and anti-inflammatory effects of warm chamomile tea have been reported in the literature. In addition, the neuroprotective, antiallergic, antioxidant, antiseptic and spasmolytic properties of chamomile have been reported. The aim was to compare the effects of these gargles in terms of pain, mouth opening, burning sensation in the mouth, edema, and discoloration of the tongue and teeth.

Start Date01 Jan 2025

Sponsor / Collaborator

Istanbul Medipol University

PACTR202411502237433

/ CompletedNot ApplicableIIT

The effects of Lavender ,Chamomile and peppermint inhalation aromatherapy on dental anxiety in children: A randomized controlled trial

Start Date15 Oct 2024

Sponsor / Collaborator-

100 Clinical Results associated with Matricaria chamomilla extract

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100 Translational Medicine associated with Matricaria chamomilla extract

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100 Patents (Medical) associated with Matricaria chamomilla extract

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1

Literatures (Medical) associated with Matricaria chamomilla extract

01 Apr 2009·Phytomedicine : international journal of phytotherapy and phytopharmacologyQ2 · MEDICINE

Observational study: Matricaria chamomilla may improve some symptoms of attention-deficit hyperactivity disorder

Q2 · MEDICINE

Article

Author: Niederhofer, H

OBJECTIVE:

Noradrenaline and serotonin reuptake inhibitors have been proven to be effective in some cases of ADHD. In this open trial, Matricaria chamomilla, a serotonin and noradrealine reuptake inhibitor, actually used as an antidepressant, has been checked for this indication.

METHOD:

Three 14-16-year-old male psychiatric outpatients, diagnosed with attention-deficit disorder (ADHD) have been rated at baseline and while taking Matricaria chamomilla to determine its efficacy as a treatment for ADHD. Improvement was valuated using comparisons of Conners' parent ratings.

RESULTS:

Patients' mean scores improved for Conners' hyperactivity, inattention and immaturity factors.

CONCLUSIONS:

Although the sample size is very small and therefore generalization is very difficult, this observation indicates that Matricaria chamomilla might be a slightly effective treatment also for ADHD.

100 Deals associated with Matricaria chamomilla extract

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Generalized anxiety disorder	Phase 3	United States	University of Pennsylvania	01 Feb 2010
stress oxidative	Preclinical	United States	Case Western Reserve University	15 Apr 2010

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01072344 (CTgov)	Phase 3	Anxiety Disorders \| Generalized anxiety disorder	180	Chamomile (Matricaria recutita) (Chamomile Extract)	vjeevpnigy(gynblaoupf) = sxwjvotayp kkblrlodfk (tpbyakigrw, 8.4) View more	-	06 Jul 2017
				Chamomile (Matricaria recutita) (Placebo)	vjeevpnigy(gynblaoupf) = nrvhyyhfim kkblrlodfk (tpbyakigrw, 3.9) View more
NCT01072344 (Pubmed \| Phytomedicine)	Phase 3	Generalized anxiety disorder	179	Chamomile pharmaceutical grade extract 1500mg	yocfnichtb(ycsfefioha) = wqilwckrxz resnqryfsk (zxqbkofljv, ± 8.4)	-	15 Dec 2016
				Placebo	yocfnichtb(ycsfefioha) = opwdzjdihe resnqryfsk (zxqbkofljv, ± 3.9)