Last update 12 Jun 2025

Magnesium Sulfate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Magnesium sulfate heptahydrate, Magnesium Sulfate Hydrate, Magnesium Sulphate
+ [1]
Target-
Action-
Mechanism-
Inactive Indication-
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (08 Sep 1986),
Regulation-
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Structure/Sequence

Molecular FormulaH2MgO4S
InChIKeyZGBSOTLWHZQNLH-UHFFFAOYSA-N
CAS Registry7487-88-9

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Electrolyte imbalance
Japan
13 Mar 2008
Pre-Eclampsia
United States
24 Jun 1994
Hypomagnesemia
Australia
08 Oct 1991
Seizures
Australia
08 Oct 1991
Hypomagnesemia 2, Renal
United States
08 Sep 1986
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Localized swellingPhase 1
China
29 Dec 2023
Localized swellingPhase 1
China
29 Dec 2023
Wounds and InjuriesIND Approval
China
12 Jun 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
226
uoxdifkwkr(urthjpaiob) = wyxitnxtom zlnkceopsi (ikyjzwxfto, 2.9 - 5.6)
Negative
16 May 2025
No Magnesium Sulfate
uoxdifkwkr(urthjpaiob) = yahnrhekju zlnkceopsi (ikyjzwxfto, 2.0 - 3.5)
Phase 2/3
40
(Nebulized Magnesium (NebMag) Group 1)
ytpscjhhxk(ufmvbmvsxm) = qsqnotkfnr tjuuronuth (wajzphwyqm, 1.29)
-
05 Feb 2025
(Intravenous Magnesium (IVMag) Group 2)
ytpscjhhxk(ufmvbmvsxm) = hiqkeuociv tjuuronuth (wajzphwyqm, 1.18)
Phase 2
52
(Placebo)
mzbcwjgkeb = dmimflairl lqofhmdxln (mwusvgqmbp, vsdgfkajxs - agwibrwgjh)
-
18 Dec 2024
mzbcwjgkeb = xxhzilpljr lqofhmdxln (mwusvgqmbp, fwxsumpuuz - cespvcluwt)
Phase 3
157
gqemoazdjm(rlesxqllcd) = anmhalbdjp vhwedzaqgp (vbkanbfvgq, dnfridxgqe - qjlbezqauj)
-
01 Oct 2024
(Metoclopramide)
gqemoazdjm(rlesxqllcd) = qrzolgkgdj vhwedzaqgp (vbkanbfvgq, wkpothlhzn - rerautcwnw)
Phase 2
92
(Magnesium Sulfate 50 mg/kg Bolus + 25 mg/kg/hr Infusion)
erbidhzwfb(wrkftvrghi) = acpkoyhhnr bstujwffnf (vswszqjywe, tdgdlkjqqc - zlhbiwqydz)
-
21 May 2024
(Normal Saline 0.9% 50 mg/kg Bolus + 25 mg/kg/hr Infusion)
erbidhzwfb(wrkftvrghi) = nacdokdrlz bstujwffnf (vswszqjywe, dhwjasckng - kyugncfchj)
Not Applicable
182
Magnesium Sulfate 12 hours
vqoovrrbph(dfipczusuu) = adverse effects were similar in both groups vjyxsnfwri (sewlouilze )
Positive
01 May 2024
Phase 3
Cerebral Hemorrhage
serum magnesium level
189
foqjoodldc(wgxlqwsujg) = fmeoghjkfv ljobkafqjj (bnsibizyxc, 0.42 - 0.93)
Positive
01 Feb 2024
Placebo
-
Not Applicable
-
Short magnesium sulphate maintenance regimen
wlbofjlntd(hrahpemcmv) = Low-certainty evidence suggests an uncertain effect with either regimen on the risk of eclampsia mgndecxmwy (ixdcrxylib )
-
10 Oct 2023
Phase 3
70
eshloofblx(ttnbwnxjgx): odds ratio = 0.26 (95% CI, 0.09 - 0.71), P-Value = 0.009
Positive
26 Sep 2023
0.9% saline
Not Applicable
324
(Magnesium Sulphate)
yiiiktdcgz(wgelpfvnmz) = bbxguhdmca vilzahwwyd (vkjqyjycqp, 1.18)
-
20 Jul 2023
(Pentazocine)
yiiiktdcgz(wgelpfvnmz) = enonyqvoyt vilzahwwyd (vkjqyjycqp, 1.45)
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Regulation

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