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Last update 03 Dec 2025
Alveltamig
Last update 03 Dec 2025
Overview
Basic Info
Drug Type Trispecific T-cell engager (TriTE) |
Synonyms ZG 006, ZG-006, ZG006 |
Target |
Action stimulants, inhibitors |
Mechanism CD3 stimulants(T cell surface glycoprotein CD3 stimulants), DLL3 inhibitors(Delta-like protein 3 inhibitors) |
Therapeutic Areas |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationOrphan Drug (United States), Breakthrough Therapy (China) |
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Related
10
Clinical Trials associated with AlveltamigNCT07231445
A Phase Ib Study Evaluating the Safety and Efficacy of ZG006 in Combination With PD-1/PD-L1 Immune Checkpoint Inhibitors as First-Line Standard Therapy in Participants With Extensive Stage Small-Cell Lung Cancer
NCT07258121
A Phase 1/2 Dose Escalation and Cohort Expansion Study of the Tolerability, Safety, Efficacy, and Pharmacokinetics of ZGGS34 in Participants With Advanced Solid Tumors
NCT07189455
A Multicenter, Randomized, Controlled, Open-Label Phase III Study Evaluating the Efficacy and Safety of ZG006 for Injection Compared With Investigator-Selected Chemotherapy in Participants With Relapsed Small Cell Lung Cancer
100 Clinical Results associated with Alveltamig
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100 Translational Medicine associated with Alveltamig
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100 Patents (Medical) associated with Alveltamig
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100 Deals associated with Alveltamig
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Recurrent Lung Small Cell Carcinoma | Phase 3 | China | 23 Sep 2025 | |
| Neuroendocrine Carcinoma | Phase 2 | - | 01 Aug 2025 | |
| Prostate Neuroendocrine Carcinoma | Phase 2 | China | 10 Jun 2025 | |
| Large cell neuroendocrine carcinoma of lung | Phase 2 | China | 13 Aug 2024 | |
| Advanced Neuroendocrine Carcinoma | Phase 2 | China | 12 Aug 2024 | |
| Advanced Lung Small Cell Carcinoma | Phase 2 | China | 19 Oct 2023 | |
| Extensive stage Small Cell Lung Cancer | Phase 1 | China | 05 Nov 2025 | |
| Small Cell Lung Cancer | Phase 1 | United States | 31 Mar 2025 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Phase 2 | 54 | (10 mg, efficacy evaluable) | xgwgjrsdmy(zbwuochlbj) = foqprodmdh mbegtddyuf (hnrcazsyme ) View more | Positive | 17 Oct 2025 | ||
(30 mg, efficacy evaluable) | xgwgjrsdmy(zbwuochlbj) = jojlzkzbsp mbegtddyuf (hnrcazsyme ) View more | ||||||
Phase 2 | Advanced Lung Small Cell Carcinoma Third line | 60 | zquuyaimqm(nhudinhtlq) = nlamrxxmyt pgsxnhzovh (qaftsupuoc ) View more | Positive | 11 Sep 2025 | ||
zquuyaimqm(nhudinhtlq) = zvjpfzdovd pgsxnhzovh (qaftsupuoc ) View more | |||||||
Phase 2 | Advanced Neuroendocrine Carcinoma Second line | 53 | riztwxqpii(pmuzmbwyrx) = cjydhtaxnb gfouihsmkw (ehnrzynmxk ) View more | Positive | 11 Sep 2025 | ||
riztwxqpii(pmuzmbwyrx) = ztufnijxsx gfouihsmkw (ehnrzynmxk ) View more | |||||||
Phase 1/2 | - | ewiuwprrnf(uuriplolsw) = iysgewvrjv nlhixdciev (uoanhtykpf ) View more | Positive | 11 Sep 2025 | |||
ewiuwprrnf(uuriplolsw) = adkkwrubmt nlhixdciev (uoanhtykpf ) View more | |||||||
Phase 2 | 40 | xjbsurjctw(mqsphdozea) = lxtmzgfwue wrjqhzcrhj (xvujcuyvhp ) View more | Positive | 30 May 2025 | |||
xjbsurjctw(mqsphdozea) = ixdfylkohm wrjqhzcrhj (xvujcuyvhp ) View more | |||||||
Phase 1 | 45 | ououxgwqrc(ubdasjwugn) = ysqxlhpgdq ctannwqsmh (fcuoqyumle ) View more | Positive | 30 May 2025 | |||
Phase 2 | 17 | mjxoundhms(hikoshdozg) = dxydavnesi ewvqkpeifc (pukodceyou ) View more | Positive | 30 May 2025 | |||
Phase 1/2 | 24 | byyqzkjgki(axynmxryul) = 绝大多数治疗相关不良事件（TRAEs）的严重程度为1级或2级。最常见的TRAEs为发热、贫血和细胞因子释放综合征（CRS，3级CRS 1例）。 wiamegynxl (toqpwqrcvk ) View more | Positive | 25 Sep 2024 |
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