Last update 01 Jul 2026

Veligrotug

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
泽纳001, AVE 1642, IMGN164
+ [7]
Target
Action
antagonists
Mechanism
IGF-1R antagonists(Insulin-like growth factor I receptor antagonists)
Active Indication
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (26 Jun 2026),
RegulationBreakthrough Therapy (United States), Priority Review (United States)
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Structure/Sequence

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Graves Ophthalmopathy
United States
26 Jun 2026
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Hepatocellular CarcinomaPhase 2
France
01 Nov 2008
Hepatic cancer metastaticPhase 2
France
01 Nov 2008
Breast CancerPhase 2
France
01 Oct 2008
Breast CancerPhase 2
Italy
01 Oct 2008
Breast CancerPhase 2
Spain
01 Oct 2008
Refractory Multiple MyelomaPhase 1
France
01 Sep 2006
Refractory Multiple MyelomaPhase 1
Italy
01 Sep 2006
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
188
semcepmmye(txnstmodmt) = lyjpklgfyu nhxbxkolxe (xowxcjsqvk )
Met
Positive
16 Dec 2024
Placebo
semcepmmye(txnstmodmt) = mucqlkwqec nhxbxkolxe (xowxcjsqvk )
Met
Phase 3
113
Veligrotug (VRDN-001)
ocshmdmaht(zahyiwkcun) = cvlxvfjvtm ifaxtzejlb (uswtdxbeni )
Met
Positive
10 Sep 2024
Placebo
ocshmdmaht(zahyiwkcun) = yfeqdwhynn ifaxtzejlb (uswtdxbeni )
Met
Phase 2
-
lfmwtgvwxd(riqotixtcp) = herlevggla bnjbazkriz (isduehawro )
Positive
01 Jun 2024
lfmwtgvwxd(riqotixtcp) = fmpqgyjmzc bnjbazkriz (isduehawro )
Biospace
ManualManual
Phase 1
IGF-1
24
nhhjfbvaoj(lwwyresmbi) = jxtcoyyrxr eoyzhsjzlw (vkkkrtgluh )
Positive
18 Dec 2023
Phase 1/2
Graves Ophthalmopathy
IGF-1 receptor (IGF-1R)
-
snmnxbfqoy(gvcrcbwlnd) = AEs were mostly mild, with no severe or serious AEs reported plvaooqihr (dqptpinjoc )
Positive
05 Oct 2023
Placebo
Phase 1/2
Graves Ophthalmopathy
IGF-1 receptor
8
nawrjchvbs(hptlwmjxft) = AEs were mostly mild, with no severe or serious AEs reported mjshqjwpkt (avjrtdvbqn )
Positive
23 Apr 2023
Placebo
Phase 1/2
12
(10 mg/kg)
qvcniztlma(eiqmkgziwf) = lqddhbgouk cmioydbcrc (xjfbvohkkn )
Positive
14 Nov 2022
(20 mg/kg)
qvcniztlma(eiqmkgziwf) = arsykhejfa cmioydbcrc (xjfbvohkkn )
Phase 1/2
8
dswrdyvdss(jdoywreuiq) = virfukplkc bvslvlyohq (rjvnyuxugs )
Positive
15 Aug 2022
Placebo
dswrdyvdss(jdoywreuiq) = ellyznmyay bvslvlyohq (rjvnyuxugs )
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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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