Last update 19 Dec 2025

Efaprinermin alfa

Overview

Basic Info

Drug Type
Fc fusion protein
Synonyms
GITRL-Fc, GITRL-Fc trimer, OMP 336B11
+ [1]
Target
GITR
Action
agonists
Mechanism
GITR agonists(Glucocorticoid-induced tumor necrosis factor receptor-related protein agonists)
Therapeutic Areas
Neoplasms
Active Indication
Neoplasms
Inactive Indication
Locally Advanced Malignant NeoplasmLocally Advanced Malignant Solid NeoplasmNeoplasm Metastasis
Originator Organization
Mereo BioPharma 5, Inc.Mereo BioPharma 5, Inc.
Active Organization
Mereo BioPharma 5, Inc.Mereo BioPharma 5, Inc.
Inactive Organization-
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-
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Structure/Sequence

Related

1
Clinical Trials associated with Efaprinermin alfa
NCT03295942
/ TerminatedPhase 1
A Phase 1a Open-Label, Dose Escalation Study of the Safety and Pharmacokinetics of OMP-336B11 Administered as a Single Agent to Subjects With Locally Advanced or Metastatic Solid Tumors
100 Clinical Results associated with Efaprinermin alfa
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100 Translational Medicine associated with Efaprinermin alfa
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100 Patents (Medical) associated with Efaprinermin alfa
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100 Deals associated with Efaprinermin alfa
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Locally Advanced Malignant NeoplasmPhase 1
United States
-12 Sep 2017
Locally Advanced Malignant Solid NeoplasmPhase 1
United States
-12 Sep 2017
Neoplasm MetastasisPhase 1
United States
-12 Sep 2017
NeoplasmsPreclinical
United States
Mereo BioPharma 5, Inc.Mereo BioPharma 5, Inc.
03 Jan 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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