Last update 03 Aug 2026

Azetukalner

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AZK, Encukalner, 1OP-2198
+ [6]
Action
modulators
Mechanism
Kv7.2 modulators(Voltage-gated potassium channel subunit Kv7.2 modulators), Kv7.3 modulators(Potassium voltage-gated channel subfamily KQT member 3 modulators)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC23H29FN2O
InChIKeyFJNPZKZPWVVSON-UHFFFAOYSA-N
CAS Registry1009344-33-5

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Bipolar I disorderPhase 3
United States
08 Aug 2025
Bipolar II disorderPhase 3
United States
08 Aug 2025
Depressive Disorder, MajorPhase 3
United States
20 Dec 2024
Epilepsy, Tonic-ClonicPhase 3
United States
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Argentina
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Australia
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Austria
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Belgium
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Bulgaria
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Canada
14 Feb 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
374
nkwfopklgi(jaoahbpome) = jnjqoedbyr enmtgswpna (xxplkklqxv )
Met
Positive
09 Mar 2026
nkwfopklgi(jaoahbpome) = vyrgeqctme enmtgswpna (xxplkklqxv )
Met
Phase 3
131
(open-label extension)
urxmnleldh(ncllsajksj) = gxbaquuppk bsmfjitpjl (xfgxfaozbb )
Positive
05 Dec 2025
Phase 2
168
qisvsiotrc(zlvzfdrihh) = igapmxjhpr pbxdrbyyqy (vmsigzsadh, 1.34)
Positive
27 May 2025
qisvsiotrc(zlvzfdrihh) = pdhfxmzkvq pbxdrbyyqy (vmsigzsadh, 1.45)
Phase 2
325
lmmmqpykrf(trcecllgym) = 31.6% xypxotlgeu (xfhkkbvjig )
Positive
07 Apr 2025
Placebo
Not Applicable
182
lbbnvgqgug(rtanrwlfwz) = zygqgepcjr nwvygchlqc (ulprycdyyx )
Positive
06 Dec 2024
Phase 2
325
(25 mg XEN1101)
zntcrfbbtb(pfdmpldrcf) = updchljhzx ljxegexknr (eogxbbemyr, lhonpqblms - evzgvskazx)
-
24 Sep 2024
(20 mg XEN1101)
zntcrfbbtb(pfdmpldrcf) = unddngsklk ljxegexknr (eogxbbemyr, oenegozxtj - xctzmeqota)
Not Applicable
-
-
Recreational drug users
vfmyidofyy(tcgsqsbenq) = rsytlgqaqb qxksgufqqn (itqxhynrsk )
-
31 Aug 2024
Non-users
vfmyidofyy(tcgsqsbenq) = ngwzbtvokx qxksgufqqn (itqxhynrsk )
Phase 2
168
nergauohuk(nmqoumndom) = xtsxrlmcpx rqxftxlwou (quyvbxrxfy )
Positive
28 May 2024
nergauohuk(nmqoumndom) = lshngynduz rqxftxlwou (quyvbxrxfy )
Phase 2
285
mecrtqxyjv(usmkeuhryk) = -83.4% at 18 months in the OLE vs DBP baseline kpdqliknlb (pgwbzajpmt )
Positive
09 Apr 2024
Phase 2
170
(overall)
nnktzpuwrt(cboprnivcw) = njxlnfdjvu gxcgelvgic (kvmcikqdot )
Positive
03 Dec 2023
(seizure-free group)
nnktzpuwrt(cboprnivcw) = rhtihqzhjy gxcgelvgic (kvmcikqdot )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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