Drug Type Small molecule drug |
Synonyms AZK, Encukalner, 1OP-2198 + [6] |
Target |
Action modulators |
Mechanism Kv7.2 modulators(Voltage-gated potassium channel subunit Kv7.2 modulators), Kv7.3 modulators(Potassium voltage-gated channel subfamily KQT member 3 modulators) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization |
Drug Highest PhasePhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC23H29FN2O |
InChIKeyFJNPZKZPWVVSON-UHFFFAOYSA-N |
CAS Registry1009344-33-5 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Bipolar I disorder | Phase 3 | United States | 08 Aug 2025 | |
| Bipolar II disorder | Phase 3 | United States | 08 Aug 2025 | |
| Depressive Disorder, Major | Phase 3 | United States | 20 Dec 2024 | |
| Epilepsy, Tonic-Clonic | Phase 3 | United States | 14 Feb 2023 | |
| Epilepsy, Tonic-Clonic | Phase 3 | Argentina | 14 Feb 2023 | |
| Epilepsy, Tonic-Clonic | Phase 3 | Australia | 14 Feb 2023 | |
| Epilepsy, Tonic-Clonic | Phase 3 | Austria | 14 Feb 2023 | |
| Epilepsy, Tonic-Clonic | Phase 3 | Belgium | 14 Feb 2023 | |
| Epilepsy, Tonic-Clonic | Phase 3 | Bulgaria | 14 Feb 2023 | |
| Epilepsy, Tonic-Clonic | Phase 3 | Canada | 14 Feb 2023 |
Phase 3 | 374 | nkwfopklgi(jaoahbpome) = jnjqoedbyr enmtgswpna (xxplkklqxv ) Met View more | Positive | 09 Mar 2026 | |||
Azetukalner 15 mg | nkwfopklgi(jaoahbpome) = vyrgeqctme enmtgswpna (xxplkklqxv ) Met View more | ||||||
Phase 3 | 131 | (open-label extension) | urxmnleldh(ncllsajksj) = gxbaquuppk bsmfjitpjl (xfgxfaozbb ) View more | Positive | 05 Dec 2025 | ||
Phase 2 | 168 | qisvsiotrc(zlvzfdrihh) = igapmxjhpr pbxdrbyyqy (vmsigzsadh, 1.34) | Positive | 27 May 2025 | |||
qisvsiotrc(zlvzfdrihh) = pdhfxmzkvq pbxdrbyyqy (vmsigzsadh, 1.45) View more | |||||||
Phase 2 | 325 | lmmmqpykrf(trcecllgym) = 31.6% xypxotlgeu (xfhkkbvjig ) View more | Positive | 07 Apr 2025 | |||
Placebo | |||||||
Not Applicable | 182 | lbbnvgqgug(rtanrwlfwz) = zygqgepcjr nwvygchlqc (ulprycdyyx ) View more | Positive | 06 Dec 2024 | |||
Phase 2 | 325 | (25 mg XEN1101) | zntcrfbbtb(pfdmpldrcf) = updchljhzx ljxegexknr (eogxbbemyr, lhonpqblms - evzgvskazx) View more | - | 24 Sep 2024 | ||
(20 mg XEN1101) | zntcrfbbtb(pfdmpldrcf) = unddngsklk ljxegexknr (eogxbbemyr, oenegozxtj - xctzmeqota) View more | ||||||
Not Applicable | - | - | Recreational drug users | vfmyidofyy(tcgsqsbenq) = rsytlgqaqb qxksgufqqn (itqxhynrsk ) | - | 31 Aug 2024 | |
Non-users | vfmyidofyy(tcgsqsbenq) = ngwzbtvokx qxksgufqqn (itqxhynrsk ) | ||||||
Phase 2 | 168 | nergauohuk(nmqoumndom) = xtsxrlmcpx rqxftxlwou (quyvbxrxfy ) | Positive | 28 May 2024 | |||
nergauohuk(nmqoumndom) = lshngynduz rqxftxlwou (quyvbxrxfy ) View more | |||||||
Phase 2 | 285 | mecrtqxyjv(usmkeuhryk) = -83.4% at 18 months in the OLE vs DBP baseline kpdqliknlb (pgwbzajpmt ) View more | Positive | 09 Apr 2024 | |||
Phase 2 | 170 | (overall) | nnktzpuwrt(cboprnivcw) = njxlnfdjvu gxcgelvgic (kvmcikqdot ) View more | Positive | 03 Dec 2023 | ||
(seizure-free group) | nnktzpuwrt(cboprnivcw) = rhtihqzhjy gxcgelvgic (kvmcikqdot ) View more |





