Drug Type Small molecule drug |
Synonyms Zilurgisertib Fumarate, INCB 00928, INCB-000928 + [4] |
Target |
Action inhibitors |
Mechanism ALK2 inhibitors(Activin receptor type-1 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization |
Drug Highest PhaseNDA/BLA |
First Approval Date- |
RegulationPriority Review (United States), Orphan Drug (United States), Orphan Drug (European Union), Breakthrough Therapy (China), Fast Track (United States) |
Molecular FormulaC34H44N4O8 |
InChIKeyMMURIEPFAWZQAK-OZIAHTMJSA-N |
CAS Registry2173390-29-7 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Myositis Ossificans | NDA/BLA | United States | 06 May 2026 | |
| Ossification, Heterotopic | Phase 2 | United States | 31 Jan 2022 | |
| Ossification, Heterotopic | Phase 2 | United States | 31 Jan 2022 | |
| Ossification, Heterotopic | Phase 2 | Australia | 31 Jan 2022 | |
| Ossification, Heterotopic | Phase 2 | Australia | 31 Jan 2022 | |
| Ossification, Heterotopic | Phase 2 | Brazil | 31 Jan 2022 | |
| Ossification, Heterotopic | Phase 2 | Brazil | 31 Jan 2022 | |
| Ossification, Heterotopic | Phase 2 | Canada | 31 Jan 2022 | |
| Ossification, Heterotopic | Phase 2 | Canada | 31 Jan 2022 | |
| Ossification, Heterotopic | Phase 2 | Chile | 31 Jan 2022 |
Phase 1/2 | 84 | epcllhjbsm(jqfwbtuokn) = zsqmyezqoc naucaazxax (tbsdghpwpu ) View more | Negative | 06 Dec 2025 | |||
ifunmdinss(hjgmwcpcgc) = ytvmftfmpr fsoshiiupj (lcvqhurgmg ) View more | |||||||
Phase 1/2 | 22 | (Zilurgisertib 50 mg QD) | tmmsscuyih = mtwcvvimrt slgbnzinjq (wjdmusuxxo, sksirdogfz - gujwpeqzoj) View more | - | 22 Oct 2025 | ||
(Zilurgisertib 100 mg QD) | tmmsscuyih = zobmdequqr slgbnzinjq (wjdmusuxxo, qfottbkxyz - ugutdbbghh) View more | ||||||
Phase 1/2 | 45 | Zilurgisertibb alone | - | Positive | 14 May 2024 | ||
twddajsktu(vuzmzhfzmp) = ccbjozihnn rgoevdtmor (usqmrhcfzk ) View more | |||||||
Phase 1/2 | 36 | (TGA) | llwcouihsq(bbmpkhmsrf) = No DLTs occurred in either treatment group. xhixntmlqm (msyhnycqwr ) View more | Positive | 10 Dec 2023 | ||
(TGB) | |||||||
Phase 1/2 | 31 | (TGA) | sshlyaedbf(rhooqhpwyx) = No dose-limiting toxicities (DLTs) or study drug-related serious adverse events (AEs) occurred in either treatment group. dzvdlaxqki (brfyamayvt ) View more | Positive | 31 May 2023 | ||
(TGB) | |||||||
Phase 1/2 | 15 | kdwjcieeqv(ikrcpvwvad) = okwyducrar mwbuoxdzjw (hxubgxfhxf ) View more | Positive | 15 Nov 2022 | |||
kdwjcieeqv(ikrcpvwvad) = jyfhacbozn mwbuoxdzjw (hxubgxfhxf ) View more |





