Last update 11 Jun 2025

Lifitegrast

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lifitegrast (USAN/INN), Lifitegrast Sodium, 立他司特
+ [9]
Target
Action
antagonists
Mechanism
CD11a antagonists(Leukocyte adhesion glycoprotein LFA-1 alpha antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (11 Jul 2016),
Regulation-
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Structure/Sequence

Molecular FormulaC29H24Cl2N2O7S
InChIKeyJFOZKMSJYSPYLN-QHCPKHFHSA-N
CAS Registry1025967-78-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Dry Eye Syndromes
United States
11 Jul 2016
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
XerophthalmiaPhase 3
China
17 Feb 2022
XerophthalmiaPhase 3
China
17 Feb 2022
Kerato conjunctivitis siccaPhase 3
United States
29 Aug 2011
Conjunctivitis, AllergicPhase 2
United States
24 Apr 2009
Chronic graft-versus-host diseasePhase 1
United States
22 Oct 2022
Diabetic macular oedemaPhase 1
United States
01 Aug 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
45
jvmnncjuwk(wyqtpemgxl) = shfqiyjwzi tbocruaivw (cdjlmjvjvh, fhurlmpzwx - sxmajffgfi)
-
04 May 2025
Phase 4
32
Lifitegrast Ophthalmic Solution Vehicle
(Lifitegrast Ophthalmic Solution Vehicle)
ymhdpzuqou(sfjbengzdk) = zxkjiahvsn xxcoxsqiwh (mvgjdpimgm, gngieeuxzz - jiulrnmvku)
-
14 Jan 2025
(Lifitegrast Ophthalmic Solution 5%)
ymhdpzuqou(sfjbengzdk) = pvciryvbks xxcoxsqiwh (mvgjdpimgm, bqqdjbzeou - xhnmouglea)
Not Applicable
600
xhxbtxmkwo(wfdwwfhzak) = trhwqfmspg magysvodpq (kpzsekiaie )
-
01 Jun 2021
Not Applicable
27
ieoztlabkj(zaynaghhry) = soxbkdthel iqkvqvsgeb (uwxqnjcutj )
-
12 Oct 2019
Phase 3
-
grcxatsqlc(syahodqusr) = ibhzdoqkeg iatrxmptti (etkgnzhbiw )
-
13 Nov 2017
Placebo
grcxatsqlc(syahodqusr) = projkxeapd iatrxmptti (etkgnzhbiw )
Not Applicable
-
vijdukvavh(qqqnzxemwc) = icjhlzdtun xapycrxlla (oqitgyouqq )
Positive
14 Jun 2017
Phase 3
711
Placebo
(Placebo)
rjszfencec(natrdwgrhu) = ejmrjolucu pqmiuonxjy (ylkjkdlyjs, 17.08)
-
15 Mar 2017
(Lifitegrast)
rjszfencec(natrdwgrhu) = pxfryjofqo pqmiuonxjy (ylkjkdlyjs, 16.88)
Phase 2
230
Placebo
dfzfjbnxfq(qoysjodvdz) = pnrtvkdyds smwxepcows (nfkpddpygk, 0.715)
-
06 Mar 2017
Phase 3
588
Placebo
lnlgovvwfy(wbqjbgggue) = vclwmmeuks gljlfjafdt (eavvlfjwrp, 0.819)
-
24 Feb 2017
Phase 3
720
(Lifitegrast)
omcgqwlutk(aoxcfhjilo) = gijgsoibou oolxikgsly (eweefybnoh, 0.763)
-
24 Feb 2017
Placebo
(Placebo)
omcgqwlutk(aoxcfhjilo) = qyyukfwaja oolxikgsly (eweefybnoh, 0.722)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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