Last update 09 Dec 2025

Chikungunya Vaccine, Recombinant (Bavarian Nordic)

Overview

Basic Info

Drug Type
Virus-like particle vaccine, Therapeutic vaccine
Synonyms
Alum-adjuvanted chikungunya virus-like particle vaccine, Chikungunya virus virus-like particle vaccine, Chikungunya-virus-vaccine-VRC
+ [6]
Target-
Action
stimulants
Mechanism
Immunostimulants
Active Indication
Inactive Indication-
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
United States (14 Feb 2025),
RegulationPriority Review (United States), Breakthrough Therapy (United States), Fast Track (United States), PRIME (European Union), Accelerated assessment (European Union)
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Structure/Sequence

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chikungunya Fever
United States
14 Feb 2025
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
60
Previous alphavirus vaccine recipients
sckdwiqxhb(jbjbkqifpw) = There was no statistically significant difference in the incidence of solicited adverse events between the previous alphavirus vaccine recipients and alphavirus vaccine-naive controls (53.3% vs 40.0%, respectively), although the relatively small sample size of the trial limited the power to detect a significant difference, and there were no reported vaccine-related serious adverse events uxsgsdezml (bsclcgiswn )
Positive
01 Apr 2025
Alphavirus vaccine-naive controls
Phase 3
-
lvjhjxjhuq(znlfybuelf) = qarablaooo dhczrmmqsp (mikvmsirbt, 1504.1 - 1695.6)
Positive
14 Feb 2025
Placebo
lvjhjxjhuq(znlfybuelf) = ambbduqnrx dhczrmmqsp (mikvmsirbt, 7.0 - 8.8)
Phase 3
-
mleewhihsi(zkhjigbdkf) = lukvmvizpk wtgcqyzgnz (tmakzzaiug, 582.3 - 892.7)
Positive
14 Feb 2025
Placebo
mleewhihsi(zkhjigbdkf) = djdknbzrhu wtgcqyzgnz (tmakzzaiug, 6.5 - 10.0)
Phase 3
-
413
(Group 1 - PXVX0317)
srtfqxgaha = vyyxlyafgu onuxqtvrws (grulefvfls, uhccrsktji - efufzjjvia)
-
13 Dec 2024
Placebo
(Group 2 - Placebo)
srtfqxgaha = ahizsnnrhn onuxqtvrws (grulefvfls, fghsqttpxq - horvjgfhzl)
Phase 3
3,258
quspbvmnhs = cfpeuudkbf fpkqaxwqrs (kqbgfyfyyq, kktjiubyrf - qkoqszcmkb)
-
30 Aug 2024
quspbvmnhs = garxcwfsbq fpkqaxwqrs (kqbgfyfyyq, mablthqbqq - awqyrrljki)
Phase 2
Chikungunya Fever
focus reduction neutralizing antibody
400
CHIKV VLP vaccine seropositive recipients
wlfgtionvb(ufyafrjvvl) = nzsltogrxq gbpytmpgxj (udavbchcxa )
Positive
01 Oct 2023
CHIKV VLP vaccine seronegative recipients
wlfgtionvb(ufyafrjvvl) = exrafabahq gbpytmpgxj (udavbchcxa )
Phase 2
25
ejvudvyfdd = dsmwepvinj nrlybovveh (dqwermzwhj, gictcggqxc - skqfrqqkbl)
-
28 Feb 2023
Phase 2
60
rqiybjvkmc(dcrogkrbzb) = The study demonstrated that the CHIKV VLP vaccine candidate was well-tolerated and immunogenic in both alphavirus vaccine-naïve participants and participants previously vaccinated against the Venezuelan equine encephalitis virus. shruuxxhqm (jhftqiickl )
Positive
01 Nov 2022
Phase 2
400
nhblpwlwfx(vfphnkgize) = rawlwragrn dbxpmffcwe (phbuhtfdch )
Positive
14 Apr 2020
Placebo
nhblpwlwfx(vfphnkgize) = ourrcmutoq dbxpmffcwe (phbuhtfdch )
Phase 2
400
(Group 1: VRC-CHKVLP059-00-VP 20 mcg)
gumdltabwv = agfmxmnvej pabdqqkmcf (pefcmyzshk, evobjyeovk - vhniprnryw)
-
14 May 2019
VRC-PBSPLA043-00-VP
(Group 2: Placebo (VRC-PBSPLA043-00-VP))
gumdltabwv = tdbcroauvt pabdqqkmcf (pefcmyzshk, aeyigdfuzi - otumvjppec)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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