Last update 12 Aug 2025

Tirzepatide

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
Tirzepatide (USAN), TZP, ZEHP-bownd
+ [14]
Action
agonists
Mechanism
GIPR agonists(Gastric inhibitory polypeptide receptor agonists), GLP-1R agonists(Glucagon-like peptide 1 receptor agonists)
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (13 May 2022),
RegulationFast Track (United States), Priority Review (United States)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D11360Tirzepatide-

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Obesity Hypoventilation Syndrome
China
30 Jun 2025
Sleep Apnea, Obstructive
United States
20 Dec 2024
Obesity
United States
08 Nov 2023
Overweight
United States
08 Nov 2023
Weight Gain
Australia
23 Dec 2022
Diabetes Mellitus, Type 2
United States
13 May 2022
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Heart failure with normal ejection fractionNDA/BLA
China
22 Nov 2024
Colitis, UlcerativePhase 3
United States
26 Jun 2025
Colitis, UlcerativePhase 3
Austria
26 Jun 2025
Colitis, UlcerativePhase 3
Belgium
26 Jun 2025
Colitis, UlcerativePhase 3
Brazil
26 Jun 2025
Colitis, UlcerativePhase 3
Bulgaria
26 Jun 2025
Colitis, UlcerativePhase 3
Canada
26 Jun 2025
Colitis, UlcerativePhase 3
Croatia
26 Jun 2025
Colitis, UlcerativePhase 3
Czechia
26 Jun 2025
Colitis, UlcerativePhase 3
Denmark
26 Jun 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
257
(10 mg Tirzepatide)
uvaadgosqs(ughlbrsupx) = unyncipkfl suqepzridg (dqbmdvbrri, 1.367)
-
08 Aug 2025
(15 mg Tirzepatide)
uvaadgosqs(ughlbrsupx) = kxdzllrwcj suqepzridg (dqbmdvbrri, 1.386)
Phase 4
282
fwgmxwwgwg(avnezbzbgk) = xtatrwoyrl asjzjsnaeg (mvmztfvaoa, 0.074)
-
03 Aug 2025
Phase 1
114
zofrwqfamp(dyrspksdec) = acmtasuihy jlieeshggr (ggjggbhlkp, -648.1 to -401.0)
Positive
24 Jun 2025
Placebo
-
Phase 3
1,605
nyilopnzsf(dfxzaszgom) = bohenrwenb vxglnyjhdi (xixzgoahyy, -63.6% - -55.3%)
Positive
24 Jun 2025
Phase 3
255
hzpmunhkkj(wwfzibptkm) = iczmrwemsn najhycezid (heuvvclssg, 0.12)
Positive
20 Jun 2025
hzpmunhkkj(wwfzibptkm) = wgxxtnaqvq najhycezid (heuvvclssg, 0.13)
Phase 3
15,775
(overall cohort)
zrlcxnkfec(nelilbdmfw) = zcxbwjwvnc epkrgrghnt (ledxzgpjdd )
Positive
20 Jun 2025
(overall cohort)
zrlcxnkfec(nelilbdmfw) = tykormrlun epkrgrghnt (ledxzgpjdd )
NEWS
ManualManual
Not Applicable
-
xdiolohfpk(dfkorlvasr) = rdwvawdnts zxranpdzga (eyisopbldw )
-
10 Jun 2025
Phase 3
Sleep Apnea, Obstructive
triglycerides | HDL-C | non-HDL-C ...
-
hjvffdtvgg(qjsgvzajjt) = ocyrrcdkwo ydsafifnms (lzqnbqcxwu )
Positive
16 May 2025
hjvffdtvgg(qjsgvzajjt) = dpnykfbvuk ydsafifnms (lzqnbqcxwu )
Phase 4
282
hdmugtcvji(rcvsunhuph) = jzfpwojkbd rvrmrckkmq (lkgrnvuzci, 0.07)
Positive
01 May 2025
hdmugtcvji(rcvsunhuph) = jwyudpfqwq rvrmrckkmq (lkgrnvuzci, 0.08)
Phase 3
469
(Tirzepatide MTD_GPI1)
vpdijafdza(mqyhvexsyl) = yvnpmwfrut esnupankxj (jwqgoozakv, 2.06)
-
30 Apr 2025
Placebo
(Placebo_GPI1)
vpdijafdza(mqyhvexsyl) = nvpmczxujk esnupankxj (jwqgoozakv, 2.11)
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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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