Drug Type Synthetic peptide |
Synonyms Tirzepatide (USAN), TZP, ZEHP-bownd + [14] |
Target |
Action agonists |
Mechanism GIPR agonists(Gastric inhibitory polypeptide receptor agonists), GLP-1R agonists(Glucagon-like peptide 1 receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (13 May 2022), |
RegulationFast Track (United States), Priority Review (United States) |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D11360 | Tirzepatide | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Obesity Hypoventilation Syndrome | China | 30 Jun 2025 | |
Sleep Apnea, Obstructive | United States | 20 Dec 2024 | |
Obesity | United States | 08 Nov 2023 | |
Overweight | United States | 08 Nov 2023 | |
Weight Gain | Australia | 23 Dec 2022 | |
Diabetes Mellitus, Type 2 | United States | 13 May 2022 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Heart failure with normal ejection fraction | NDA/BLA | China | 22 Nov 2024 | |
Colitis, Ulcerative | Phase 3 | United States | 26 Jun 2025 | |
Colitis, Ulcerative | Phase 3 | Austria | 26 Jun 2025 | |
Colitis, Ulcerative | Phase 3 | Belgium | 26 Jun 2025 | |
Colitis, Ulcerative | Phase 3 | Brazil | 26 Jun 2025 | |
Colitis, Ulcerative | Phase 3 | Bulgaria | 26 Jun 2025 | |
Colitis, Ulcerative | Phase 3 | Canada | 26 Jun 2025 | |
Colitis, Ulcerative | Phase 3 | Croatia | 26 Jun 2025 | |
Colitis, Ulcerative | Phase 3 | Czechia | 26 Jun 2025 | |
Colitis, Ulcerative | Phase 3 | Denmark | 26 Jun 2025 |
Phase 3 | 257 | (10 mg Tirzepatide) | uvaadgosqs(ughlbrsupx) = unyncipkfl suqepzridg (dqbmdvbrri, 1.367) View more | - | 08 Aug 2025 | ||
(15 mg Tirzepatide) | uvaadgosqs(ughlbrsupx) = kxdzllrwcj suqepzridg (dqbmdvbrri, 1.386) View more | ||||||
Phase 4 | 282 | fwgmxwwgwg(avnezbzbgk) = xtatrwoyrl asjzjsnaeg (mvmztfvaoa, 0.074) View more | - | 03 Aug 2025 | |||
Phase 1 | 114 | zofrwqfamp(dyrspksdec) = acmtasuihy jlieeshggr (ggjggbhlkp, -648.1 to -401.0) | Positive | 24 Jun 2025 | |||
Placebo | - | ||||||
Phase 3 | 1,605 | nyilopnzsf(dfxzaszgom) = bohenrwenb vxglnyjhdi (xixzgoahyy, -63.6% - -55.3%) View more | Positive | 24 Jun 2025 | |||
Phase 3 | 255 | Tirzepatide 5 mg | hzpmunhkkj(wwfzibptkm) = iczmrwemsn najhycezid (heuvvclssg, 0.12) View more | Positive | 20 Jun 2025 | ||
Tirzepatide 10 mg | hzpmunhkkj(wwfzibptkm) = wgxxtnaqvq najhycezid (heuvvclssg, 0.13) View more | ||||||
Phase 3 | 15,775 | (overall cohort) | zrlcxnkfec(nelilbdmfw) = zcxbwjwvnc epkrgrghnt (ledxzgpjdd ) | Positive | 20 Jun 2025 | ||
(overall cohort) | zrlcxnkfec(nelilbdmfw) = tykormrlun epkrgrghnt (ledxzgpjdd ) | ||||||
NEWS Manual | Not Applicable | - | xdiolohfpk(dfkorlvasr) = rdwvawdnts zxranpdzga (eyisopbldw ) View more | - | 10 Jun 2025 | ||
Phase 3 | - | hjvffdtvgg(qjsgvzajjt) = ocyrrcdkwo ydsafifnms (lzqnbqcxwu ) View more | Positive | 16 May 2025 | |||
hjvffdtvgg(qjsgvzajjt) = dpnykfbvuk ydsafifnms (lzqnbqcxwu ) View more | |||||||
Phase 4 | 282 | hdmugtcvji(rcvsunhuph) = jzfpwojkbd rvrmrckkmq (lkgrnvuzci, 0.07) View more | Positive | 01 May 2025 | |||
hdmugtcvji(rcvsunhuph) = jwyudpfqwq rvrmrckkmq (lkgrnvuzci, 0.08) View more | |||||||
Phase 3 | 469 | (Tirzepatide MTD_GPI1) | vpdijafdza(mqyhvexsyl) = yvnpmwfrut esnupankxj (jwqgoozakv, 2.06) View more | - | 30 Apr 2025 | ||
Placebo (Placebo_GPI1) | vpdijafdza(mqyhvexsyl) = nvpmczxujk esnupankxj (jwqgoozakv, 2.11) View more |