Regional Institute of Medical Sciences

Introduction Peripheral pulmonary lesions (PPLs) pose a significant diagnostic challenge for the clinician as they are not visualized within the bronchial tree during flexible bronchoscopy. Radial endobronchial ultrasound (EBUS) is a minimally invasive bronchoscopic technique that expands the view of the bronchoscopist beyond the lumen of the airway, offering a promising diagnostic modality for PPLs. Objectives To assess the types of different peripheral pulmonary lesions diagnosed by radial endobronchial ultrasound-guided biopsy, and also to assess the agreement between the findings of radiological imaging and radial EBUS-guided biopsy in determining benign and malignant peripheral pulmonary lesions. Methodology This was a cross-sectional study performed on 40 patients aged ≥18 years with radiological evidence of PPLs who attended the respiratory medicine outpatient department (OPD) of the Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, from April 2023 to March 2025. Results This study determined the diagnostic yield of radial EBUS to be 77.5%. Among the malignant lesions diagnosed, adenocarcinoma (15 patients, 37.5%) was the most common histopathological type followed by squamous cell carcinoma (eight patients, 20%) and small cell carcinoma (one patient, 2.5%) while benign lesions included pulmonary tuberculosis (five patients, 12.5%) and pulmonary aspergillosis (two patients, 5%). Substantial agreement (Kappa=0.674, p<0.001) was found between CT diagnosis and radial EBUS transbronchial lung biopsy (TBLB) findings in classifying lesions as benign or malignant. Conclusion In this study, radial EBUS-guided TBLB was found to be a safe and effective diagnostic modality for PPLs, offering high diagnostic yield and strong concordance with imaging findings, reinforcing its value in clinical decision-making.

The recontouring of disfigured maxillofacial and dental parts in prosthodontics is a process that goes beyond physical alteration, significantly enhancing patients' psychological well-being. This paper comprehensively analyzes the techniques, materials, and clinical approaches used in the cosmetic recontouring of disfigured parts, such as teeth, gingival tissues, maxillofacial, and somatic (missing body parts like fingers, hands, or prosthetic legs) prostheses. It elaborates on the clinical and laboratory steps involved in the fabrication of auricular prostheses using room temperature vulcanizing (RTV) silicone as a maxillofacial material, which gives a life-like appearance. It helps regain the overall aesthetics of the patient. The prosthesis was well retained through the use of silicone adhesives and the available undercut present at the ear defect site. The prognosis was good in terms of retention, stability, support of the prosthesis, and comfort for the patient, even after six months of follow-up. Additionally, it gives insights into higher-quality, affordable, and readily available advanced recontour prosthesis materials and modern techniques employed. Recontouring of maxillofacial, somatic, and dental structures is not just a professional duty but a moral imperative, ensuring that the patient's needs and well-being are at the forefront of every decision.

This research examined the efficiency of the two photosensitizers and assessed the efficacy of photodynamic therapy (PDT) using methylene blue and toluidine blue as supplements to scale and root planing (SRP) in the treatment of chronic periodontitis.

Group I (SRP alone), group II (SRP + methylene blue-mediated PDT), and group III (SRP + toluidine blue-mediated PDT) included 30 patients with chronic periodontitis, each of whom had 10 members. At baseline, 1 month, and 3 months, clinical measures such as gingival index (GI), plaque index (PI), probing pocket depth (PPD), and clinical attachment level (CAL) were measured. Bacterial numbers were assessed by microbiological techniques.

From baseline to 1 and 3 months, all groups exhibited substantial improvements in clinical parameters and bacterial counts (P < 0.05). The groups did not, however, vary significantly from one another (P > 0.05). In conclusion, the clinical and microbiological results of photodynamic treatment with methylene blue or toluidine blue as adjuncts to SRP were similar to those of SRP alone.

The study’s conclusions emphasize how crucial it is to understand how CIR, bone loss, and implant stability interact when designing restorations that are supported by implants. To confirm these findings and provide more solid recommendations for CIR in various therapeutic contexts, future studies with bigger sample numbers and longer follow-up times are advised.